Our research program seeks to understand the effect of various factors on the regulation of gluconeogenesis. Glucose turnover measurements using stable isotopes and mass spectrometry technique provide definite evidence for a metabolic dysfunction when measured in a disease condition in contrast to a healthy state. My laboratory carry out total glucose production and gluconeogenesis rates measurements in human volunteers and in genetic mice models using stable isotope labeled glucose and water (natural and non-radioactive), in order to investigate glucose metabolism among various conditions.
We are currently studying hormone leptin’s role in the regulation of glucose metabolism. The goal of this project is to understand the role of leptin and leptin receptor on hepatic glucose production via gluconeogenesis and glycogenolysis. We are also investigating the effect of certain small molecules on glucose production via gluconeogenic pathway.