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Department of Molecular and Human Genetics

Knockout Mouse Project

Master
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About the Project

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The Knockout Mouse Phenotyping Program (KOMP2) sites at Baylor College of Medicine, Jackson Laboratory, and University of California, Davis, are collaborating with the International Mouse Phenotyping Consortium (IMPC) to knockout and characterize all protein-coding genes in the mouse genome. Knocking out the activity of a gene provides valuable clues about what that gene normally does. However, creating and characterizing mice with gene knockouts is a time-consuming and difficult process, and is often done by individual research labs with varied approaches. Since the founding of the program, KOMP2 scientists have adhered to uniform phenotyping protocols, data collection, and reporting standards, made all data available via on IMPC website, and deposited all knockout mouse models into repositories for distribution to the scientific community. The current 5-year funding period of KOMP2 is creating and characterizing knockout mice for 1,227 genes.

KOMP2 awardees, in conjunction with the IMPC, have published many peer-reviewed publications, including papers systematically describing genes with previously unknown function in bone, eye, embryonic development, metabolism, pain perception, and human disease. Overall, this effort helps scientists explain the genetic basis of many different types of diseases in mice that also occur in humans, including rare diseases that have been under-studied as well as some common chronic diseases that affect much of the human population.

All mouse model production and phenotyping data generated by the BCM KOMP2 are available through the IMPC website. Mouse models produced by BCM are made available through the Mutant Mouse Resource and Research Centers (MMRRC).

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Principal Investigators

People
First Name
Mary
Middle Name
E.
Last Name
Dickinson
Honorific Title
Ph.D.
Senior Vice President and Dean of Research
First Name
Jason
Middle Name
D
Last Name
Heaney
Honorific Title
Ph.D.
Associate Professor
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Program Manager

People
First Name
Denise
Last Name
Lanza
Honorific Title
Ph.D.
Assistant Professor
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Members

People
First Name
Audrey
Middle Name
E.
Last Name
Christiansen
Honorific Title
Ph.D., B.S.
Instructor
First Name
Chih-Wei
Middle Name
Logan
Last Name
Hsu
Honorific Title
Ph.D.
Assistant Professor
First Name
Isabel
Last Name
Lorenzo
Honorific Title
B.S.
Instructor
First Name
Uma
Last Name
Ramamurthy
Honorific Title
Ph.D., MBA
Associate Professor
First Name
Kiran
Last Name
Rajaya
Senior Manager, IT Infrastructure and Systems
First Name
Tara
Middle Name
L.
Last Name
Rasmussen
Research Associate
First Name
Surabi
Last Name
Veeraragavan Ph.D.
Assistant Professor
First Name
Christopher
Last Name
Ward
Honorific Title
Ph.D.
Assistant Professor/Director Mouse Metabolism and Phenotyping Core
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News

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Baylor receives $12 million grant for third phase of Knockout Mouse Phenotyping Program.

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