Viral gastroenteritis around the world causes 200,000 deaths globally each year. Mary Estes talks about her work on two gastroenteritis-causing viruses, rotavirus and norovirus, and tells the story of her discovery of the first viral enterotoxin. She also describes how noroviruses have changed from human volunteer studies to studies using “miniguts,” a system now used with many enteropathogenic microorganisms.
Co-principal investigators Drs. Joseph Petrosino and Richard Gibbs were awarded a grant of up to $19.5 million from the NIH Genomic Centers of Infectious Diseases Program to study mucosal infection through the use of genomics and organoid model systems.
In celebration of Woman's History Month, BCM highlights the research of Baylor Women of Science, including the work of Drs. Janet Butel, Mary Estes, and Rebecca Rico-Hesse.
As part of BCM's "Ask Me About My Research" series, Dr. Paul Ling describes his work on herpesvirus in elephants to a young guest.
Drs. Mary K. Estes, Jeanette M. Criglar, B V Venkataram Prasad and colleagues have discovered that a cellular protein called CK1α is required to assemble rotavirus factories. See Image of the Month: Assembling a rotavirus factory.
A study by Drs. Sasirekha Ramani, Mary K. Estes, and colleagues showed that sugars in mother’s milk influence neonatal rotavirus infection.
Dr. Lawrence Donehower and colleagues have shown that the PPM1D gene can confer blood cells exposed to the chemotherapy agent cisplatin a survival advantage that might favor the development of leukemia years later.
Dr. Joseph Petrosino and colleagues have identified distinct stages in infant microbiome development. Published in the journal Nature, their results are based on extensive analysis of data collected from a cohort of participants involved in the TEDDY diabetes study (The Environmental Determinants of Diabetes in the Young).
Dr. Betty Slagle and her team have been awarded one of the first grants from Baylor for precision medicine and population health topics for the project "Human liver organoid infection model for hepatitis B virus."
Research by Dr. Gretchen Diehl and colleagues reveals how the intestinal microbiota interact with the immune system to limit a damaging inflammatory response.
A study by Dr. Rebecca Rico-Hesse and colleagues showed that mosquito saliva alone can induce a diverse and complex immune response.
Dr. Margaret Conner was a guest scientist on a segment of the NPR program Science Friday about the relationship between immunoglobulin A and the microbiome.
Dr. Peter Hotez has been elected to the American Academy of Arts and Sciences, one of the nation's most prestigious honorary titles.
Dr. Paul Ling and colleagues identified T cell immune responses directed against elephant endotheliotropic herpesvirus, which could lead to the development of an effective vaccine for this deadly disease.
Dr. Lynn Zechiedrich gave a presentation at the annual meeting of the National Academy of Inventors in Washington D.C. where she was inducted as a 2017 Fellow.
Years of basic research on rotavirus and vaccine candidate virus-like particles by Dr. Mary Estes, Dr. Sue Crawford, Dr. Margaret E. Conner, Dr. Sarah E. Blutt and other leads to a licensing agreement with ImmuCell and the development of a product to protect newborn calves from the diarrhea-causing disease.
The American Gastroenterological Association honors Dr. Mary Estes with the prestigious William Beaumont Prize in Gastroenterology and the Distinguished Mentor Award, marking the first time an AGA member has been awarded two recognition prizes in the same year.
Drs. Paul Ling and Angela Fuery identified three potential vaccine candidates for the lethal elephant endotheliotropic herpesvirus (EEHV) in a research collaboration with the Houston Zoo.
Dr. Pedro A. Piedra explained the symptoms and risks of respiratory syncytial virus, RSV, the most important respiratory virus of infants and young children.
Dr. Buck Samuel has received a New Innovator Award from the National Institutes of Health, an award which funds unusually innovative research from early career investigators.
Chikungunya virus vaccine trial has been initiated at Baylor as part of the NIH-funded Vaccine and Treatment Evaluation Unit with Dr. Hana El Sahly as principal investigator.
Drs. Anthony Maresso and Frank Ramig have reported that bacteriophages can effectively combat antibiotic-resistant bacterial "superbugs".
A study by Drs. Mary Estes, Sarah E. Blutt, Sue E. Crawford, Margaret E. Conner, and others showed that human rotavirus manipulates the immune response to maintain infection.
Dr. Mary Estes and colleagues have, for the first time, succeeded at growing noroviruses in laboratory cultures of human intestinal epithelial cells.
Dr. Qizhi Cathy Yao was the first recipient of the Barry Stephen Smith Memorial Pancreatic Cancer Award through the NCI-designated Dan L Duncan Comprehensive Cancer Center for her pilot project “A Personalized Pre-Clinical Study of a Novel Pancreatic Cancer Immunotherapy.”
Dr. Janet Butel was honored at the Texas Medical Center Women’s History Project reception.
Dr. Pedro Piedra was quoted in an Associated Press story about developing a better vaccine for next flu season.
Dr. Mary Estes and collaborators reported on a bacterial protein that activates the innate immune system against rotavirus.
Dr. Peter Hotez was interviewed by media outlets about putting Ebola's risks into perspective.
Dr. Janet Butel was among the women honored at The Health Museum's Hearts of Gold Gala.
Dr. Mary Estes and colleagues reported a reverse genetics system that could ease norovirus research.
Dr. Joseph M. Hyser has received the Elsevier Pilot Research Award from the American Gastroenterological Association Research Foundation.
Dr. Janet Butel was honored at the 2013 BioHouston Luncheon celebrating Women in Science.