Administrative Core
The Administrative Core oversees the administration of funds within the center and harmonizes the workflows within and between the center’s cores. The core also helps organize outreach strategy to recruit community-based nominations of human allele variants.
- Lead: Jason Heaney, Ph.D.
- Co-Leads: Lindsay Burrage, M.D., Ph.D. and Aleks Milosavljevic, Ph.D.
- Program Manager: Denise Lanza, Ph.D.
Clinical Translational Core
The Clinical Translational Core coordinates variant nominations, reviews phenotype information, collects and reviews medical records (if needed), and facilitates the review of nominations to the center.
- Lead: Lindsay Burrage, M.D., Ph.D.
- Co-Lead: Jill Mokry, M.S., C.G.C.
Bioinformatics Core
The Bioinformatics Core provides a bioinformatics environment for the evaluation of nominated variants and assists with analysis of human-model multi-omics data. The core supports the database management and data visualization and dissemination needs of the center.
- Lead: Matthew Roth, Ph.D.
- Co-Lead: Aleks Milosavljevic, Ph.D.
Disease Modeling Unit
The Disease Modeling Unit is responsible for producing and phenotyping the center’s precision fly and mouse models of human disease-associated genetic variation. Moreover, the unit assesses whether a rhesus macaque spontaneous mutation model is available in the national primate colonies.
- Lead: Jason Heaney, Ph.D.
- Co-Lead: Shinya Yamamoto, D.V.M., Ph.D.
Resources and Services Core
The Resources and Services Core evaluates and breeds animal models of the highest quality and distribute these resources to the community. The core functions as the primary contact for outside investigators seeking access to our services and animal resources.
- Lead: Denise Lanza, Ph.D.
- Co-Lead: Hugo Bellen, D.V.M., Ph.D.