A BD1-inhibitor shown as red and teal ball-and-stick model binds to each of four BD1-containing protein molecules colored in tan, magenta, gray and red. Image courtesy of the authors/PNAS, 2022.
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The researchers conducted 3D molecular studies to determine the precise location on the BD1 protein to which the BD1-inhibitor binds. They discovered that the BD1-inhibitor binds to a shallow area on the BD1 protein – this is not seen in other BD1 inhibitors. This finding represents a new opportunity to explore other BD1-selective inhibitors. View BCM blog article.