About the Center
The center has been established for comprehensive study of lysosome regulation and signaling in aging and Alzheimer's disease. The center will oversee the Public Health Service Grant P01 AG066606 (PHS 398).
The center consists of three highly interactive projects, all centered on the identification of post-translational modification (PTM) patterns of TFEB in response to aging and stress (Project 1), Tauopathy (Project 2), and TMEM106B (Project 3), and associated changes of the lysosomal properties. The cores will support the projects by performing unbiased lysosomal proteomic (Core B) and metabolomic (Core C) profiling. A web based ATLas of the lysosomal proteome and metabolome will also be developed (Core A).
Program Project Grant
The Lysosome Regulation and Signaling in Aging and AD was submitted for the Public Health Service Grant P01 AG066606 (PHS 398). The overarching goal of this Program Project Grant is to investigate signaling pathways regulating lysosomal homeostasis in aging and Alzheimer’s disease. The lysosome plays a critical role in the clearance of protein aggregate whose function declines with aging.
The Program Project Grant will have a lasting impact on the field in the following ways:
- Address critical barriers to understanding lysosomal biology in aging and AD, particularly in the context of pathological tau which is increasingly recognized as a key disease-driving factor in Alzheimer's disease.
- Intervention in Alzheimer's disease and other protein aggregate pathologies by uncovering molecular pathways to harness innate lysosomal sensing mechanisms and clearance capacity.
- Produce a first-in-class Aging- and Tauopathy-associated Lysosomal atlas (ATLas).
Cores
The Program Project Grant is comprised of three cores. View information and members of each core.
Projects
The Program Project Grant investigators and trainees are involved in three main projects. View information on each project.
