!

Weather Update

BCM Family Medicine on Kirby is without electrical power. Patients with appointments on Monday at this location will be moved to Baylor Medicine on the McNair Campus:  7200 Cambridge St, 7th floor, Suite 7B. Patients will be contacted. For questions, call 713-798-7700.

Research

Center for Lysosome Regulation and Signaling Research in Aging and Alzheimer's Disease

Master
Heading

Our Team

Content

Meet the investigators working to understand lysosomal-nuclear signaling in aging and
disease.

Meet Our Team
Heading

Our Research

Content

Learn about our three central research projects and supporting core specialties converging on lysosomal biology.

Projects and Cores
Heading

ATLAS

Content

The work from these projects has been uploaded into a visualization tool to promote data sharing, called Atlas, Aging and Taupathy Lysomal Atlas.

ATLAS
Heading

Publications

Content

View a listing of publications from the members of the Center for Lysosome Regulation and Signaling Research in Aging and Alzheimer's Disease Research Center.

View Publications
Heading

Program Grant

Content

The Lysosome Regulation and Signaling in Aging and AD was submitted for the Public Health Service Grant P01 AG066606  (PHS 398). The overarching goal of this Program Project Grant is to investigate signaling pathways regulating lysosomal homeostasis in aging and Alzheimer’s disease. The lysosome plays a critical role in the clearance of protein aggregate whose function declines with aging.

The Program Project Grant will have a lasting impact on the field in the following ways:

  • Address critical barriers to understanding lysosomal biology in aging and AD, particularly in the context of pathological tau which is increasingly recognized as a key disease-driving factor in Alzheimer's disease.
  • Intervention in Alzheimer's disease and other protein aggregate pathologies by uncovering molecular pathways to harness innate lysosomal sensing mechanisms and clearance capacity.
  • Produce a first-in-class Aging- and Tauopathy-associated Lysosomal atlas (ATLas).
Back to topback-to-top