TMEM106B regulates microglial proliferation and survival in response to demyelination
Zhang, T., Pang, W., Feng, T., Guo, J., Wu, K., Nunez Santos, M., Arthanarisami, A., Nana, A.L., Nguyen, Q., Kim, P.J., Jankowsky, J.L., Seeley, W.L., Hu, F.
Sci Adv. (in press).
PMID: 37146150
TMEM106B coding variant is protective and deletion detrimental in a mouse model of tauopathy
Edwards, G.A. III, Wood, C.A., Nguyen, Q., Kim, P.J., Gomez-Gutierrez, R., Park, K.-W., Zurhellen, C., Al-Ramahi, I., and Jankowsky, J.L.
bioRxiv (2023)
PMCID: 10055407
TFEB-vacuolar ATPase signaling regulates lysosomal function and microglial activation in tauopathy
Wang, B., Martini-Stoica, H., Qi, C., Lu, T. C., Wang, S., Xiong, W., Qi, Y., Xu, Y., Sardiello, M., Li, H., Zheng, H.
bioRxiv. 2023 Feb 6:2023.02.06.527293. doi: 10.1101/2023.02.06.527293.
PMCID: PMC9934527.
Autophagy deficiency modulates microglial lipid homeostasis and aggravates tau pathology and spreading
Xu, Y., Propson, N.E., Du, S., Xiong, W., and Zheng, H. Proc. Natl. Acad. Sci. USA 2021; 118(27): e2023418118.
PMCID: 8271658
TFEB regulates lysosomal exocytosis of tau and its loss of function exacerbates tau pathology and spreading
Xu, Y., Du, S., Marsh, J.A., Horie, K., Sato, C., Ballabio, A., Karch, C.M., Holtzman, D.M., and Zheng, H. Mol. Psych. 2020; https://doi.org/10.1038/s41380-020-0738-0.
PMCID: 7609570
The cargo receptor SQSTM1 ameliorates neurofibrillary tangle pathology and spreading through selective targeting of pathological MAPT (microtubule associated protein Tau)
Xu, Y., Zhang, S., and Zheng, H. Autophagy 2019; 15(4): 583-98.
PMCID: 6526869
High-Throughput Quantitative Top-Down Proteomics: Histone H4
Holt MV, Wang T, Young NL.J Am Soc Mass Spectrom. 2019 Dec;30(12):2548-2560. doi: 10.1007/s13361-019-02350-z. Epub 2019 Nov 18.
PMID: 31741267
Abnormal glycogen storage in tuberous sclerosis complex caused by impairment of mTORC1-dependent and -independent signaling pathways
Pal R, Xiong Y, Sardiello M.Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):2977-2986. doi: 10.1073/pnas.1812943116. Epub 2019 Feb 6.
PMID: 30728291
TFEB enhances astroglial uptake of extracellular tau species and reduces tau spreading
Martini-Stoica, H., Cole, A.L., Swartzlander, D.B., Chen, F., Wan, Y.-W., Bajaj, L., Bader, D.A., Lee, V.M.-Y., Trojankowski, J.Q., Liu, Z., Sardiello, M., and Zheng, H. J. Exp. Med. 2018; 215(9): 2355-77.
PMCID: 6122971
Middle-Down Characterization of the Cell Cycle Dependence of Histone H4 Posttranslational Modifications and Proteoforms
Jiang T, Hoover ME, Holt MV, Freitas MA, Marshall AG, Young NL.Proteomics. 2018 Jun;18(11):e1700442. doi: 10.1002/pmic.201700442.
PMID: 29667342
CLN8 is an endoplasmic reticulum cargo receptor that regulates lysosomebiogenesis
di Ronza A, Bajaj L, Sharma J, Sanagasetti D, Lotfi P, Adamski CJ, Collette J, Palmieri M, Amawi A, Popp L, Chang KT, Meschini MC, Leung HE, Segatori L, Simonati A, Sifers RN, Santorelli FM, Sardiello M.Nat Cell Biol. 2018 Dec;20(12):1370-1377. doi: 10.1038/s41556-018-0228-7. Epub 2018 Nov 5.
PMID: 30397314
Src regulates amino acid-mediated mTORC1 activation by disrupting GATOR1-Rag GTPase interaction
Pal R, Palmieri M, Chaudhury A, Klisch TJ, di Ronza A, Neilson JR, Rodney GG, Sardiello M.Nat Commun. 2018 Oct 19;9(1):4351. doi: 10.1038/s41467-018-06844-4.
PMID: 30341294
