Unassisted NMR usage: access for trained users
Users with expertise in NMR data acquisition can schedule instrument time to perform unassisted analysis, using standard 1D and 2D pulse sequences, after one or several hour-long training sessions (depending on previous experience).
Assisted NMR usage: fee-for-service data acquisition and analysis
Research groups lacking NMR expertise can arrange for core personnel to acquire and analyze NMR data to identify or determine the conformations of small molecules, to identify and quantify metabolites, or for feasibility studies in ligand/target screening, mapping of ligand/protein interactions, or NMR structure determination. Consult core personnel for advice on experimental design.
Target-directed ligand binding and compound library screening
NMR can be used to quantify ligand binding or to screen libraries of hundreds to thousands of compounds against purified targets. Compound libraries and the DNA-encoded (DEC-Tec) platform are available through the BCM Center for Drug Discovery. Core personnel are available to discuss the relative merits of different approaches and to analyze the resulting data. Through the Center for Drug Discovery, follow-up validation and diversification of screening or selection hits can be performed based on available structure-activity relationship data.