Drug Discovery
1. Lu D, Chen J, Qin L, Bijou I, Yi P, Li F, Song X, MacKenzie KR, Yu X, Yang B, Roy Chowdhury S, Korp JD, O’Malley BW, Lonard DM, Wang J. Lead Compound Development of SRC-3 Inhibitors with Improved Pharmacokinetic Properties and Anticancer Efficacy. J Med Chem. United States; 2024 Apr 11;67(7):5333–5350. PMCID: PMC11105966
2. Yu X, Lu D, Qi X, Lin H, Holloman BL, Jin F, Xu L, Ding L, Peng W, Wang MC, Chen X, Wang J. Development of a First-in-Class RIPK1 Degrader to Enhance Antitumor Immunity. United States; BioRxiv 2024.
3. Paudel RR, Lu D, Roy Chowdhury S, Monroy EY, Wang J. Targeted Protein Degradation via Lysosomes. Biochemistry. United States; 2023 Feb 7;62(3):564–579. PMCID: PMC10245383
4. Lu D, Yu X, Lin H, Cheng R, Monroy EY, Qi X, Wang MC, Wang J. Applications of covalent chemistry in targeted protein degradation. Chem Soc Rev. England; 2022 Nov 14;51(22):9243–9261. PMCID: PMC9669245
5. Yu X, Guo WH, Lin H, Cheng R, Monroy EY, Jin F, Ding L, Lu D, Qi X, Wang MC, Wang J. Discovery of a potent BTK and IKZF1/3 triple degrader through reversible covalent BTK PROTAC development. Curr Res Chem Biol. Netherlands; 2022;2:100029. PMCID: PMC9879287
6. Guo WH, Qi X, Yu X, Liu Y, Chung CI, Bai F, Lin X, Lu D, Wang L, Chen J, Su LH, Nomie KJ, Li F, Wang MC, Shu X, Onuchic JN, Woyach JA, Wang ML, Wang J. Enhancing intracellular accumulation and target engagement of PROTACs with reversible covalent chemistry. Nat Commun. England; 2020 Aug 26;11(1):4268. PMCID: PMC7450057
7. Song X, Chen J, Zhao M, Zhang C, Yu Y, Lonard DM, Chow DC, Palzkill T, Xu J, O’Malley BW, Wang J. Development of potent small-molecule inhibitors to drug the undruggable steroid receptor coactivator-3. Proc Natl Acad Sci U S A. United States; 2016 May 3;113(18):4970–4975. PMCID: PMC4983835
Assay Development
1. Wang L, Lin H, Yang B, Jiang X, Chen J, Roy Chowdhury S, Cheng N, Nakata PA, Lonard DM, Wang MC, Wang J. Development of a Novel Amplifiable System to Quantify Hydrogen Peroxide in Living Cells. J Am Chem Soc. United States; 2024 Jul 30; ASAP. PMID: 39079063
2. Lin H, Riching K, Lai MP, Lu D, Cheng R, Qi X, Wang J. Lysineless HiBiT and NanoLuc Tagging Systems as Alternative Tools for Monitoring Targeted Protein Degradation. ACS Med Chem Lett. United States; 2024 Jul 28, ASAP. Featured as Editor’s Choice.
3. Lin H, Wang L, Jiang X, Wang J. Glutathione dynamics in subcellular compartments and implications for drug development. Curr Opin Chem Biol. England; 2024 Jul 24;81:102505. PMID: 39053236
4. Yu X, Lin H, Li F, Wang J, Lu D. Development of Biochemical and Cellular Probes to Study RIPK1 Target Engagement. ACS Med Chem Lett. United States; 2024 Jun 13;15(6):906–916. PMCID: PMC11181498
5. Jiang X, Zhang C, Chen J, Choi S, Zhou Y, Zhao M, Song X, Chen X, Maletic-Savatic M, Palzkill T, Moore D, Wang MC, Wang J. Quantitative Real-Time Imaging of Glutathione with Subcellular Resolution. Antioxidants & redox signaling. 2019 Jun 1;30(16):1900–1910. PMCID: PMC6486671
6. Chen J, Jiang X, Zhang C, MacKenzie KR, Stossi F, Palzkill T, Wang MC, Wang J. Reversible Reaction-Based Fluorescent Probe for Real-Time Imaging of Glutathione Dynamics in Mitochondria. ACS Sens. United States; 2017 Sep 22;2(9):1257–1261. PMCID: PMC5771714
7. Jiang X, Chen J, Bajic A, Zhang C, Song X, Carroll SL, Cai ZL, Tang M, Xue M, Cheng N, Schaaf CP, Li F, MacKenzie KR, Ferreon ACM, Xia F, Wang MC, Maletic-Savatic M, Wang J. Quantitative real-time imaging of glutathione. Nature communications. 2017 Jul 13;8:16087. PMCID: PMC5511354
8. Chen J, Jiang X, Zhang C, MacKenzie KR, Stossi F, Palzkill T, Wang MC, Wang J. Reversible reaction-based fluorescent probe for real-time imaging of glutathione dynamics in mitochondria. ACS sensors. 2017;2(9):1257–1261.