Center for Space Medicine

Translational Research Institute for Space Health Research


TRISH Scientific Initiatives Overview


Advancing Commercial Space Research

As commercial spaceflight takes off, the EXPAND Program seizes new opportunities to study human adaption and physiology. TRISH works with commercial spaceflight providers and their participants to increase engagement in human research and collect essential biomedical data before, during and after spaceflight. This information is securely maintained in the Institute’s centralized EXPAND database, the world’s first and only private space health research repository. It will offer researchers unparalleled access to biological samples and data from a diverse pool of spaceflight participants.

Medical System Architecture

To enable an effective health and performance system, healthcare providers and spaceflight crews need access to current and comprehensive health and performance data to make evidence-based decisions. However, there will be a variety of sources before, during and after a mission that contribute health and performance data creating a fragmented record and inconsistent access. TRISH’s goal is to enable a robust and democratized heath record that accompanies the astronaut making health information and data from a variety of sources useful and accessible, even when the crew is far from Earth.

SENTINEL: Tissues-Chips

TRISH is accelerating human tissue chips system technologies to provide an advanced biological platform to study long-duration deep space exposure. These advanced systems will be automated and have embedded analytic capability allowing researchers to characterize the biological effects of deep space exposure and test personalized countermeasures to protect humans exploring space without requiring samples be returned to Earth for analysis.

BEES: Biology Engineered for Exploration of Space

With the establishment of the Moon to Mars Program Office, NASA and Congress have prioritized planning for deep space exploration class missions. These future missions could last three to five years and will require a large amount of supplies to sustain life including food, medication, and other products that cannot be recycled or re-supplied during the mission. For the food and medical systems, the volume of consumables, as well as the possible expiration of nutrients and medications make our current means of providing the necessary resources ineffective. New and novel approaches to provide these vital resources will be necessary. To meet these extreme needs, TRISH is in search of disruptive solutions to advance the continuous or as-needed (just-in-time) provisioning of food, micronutrients, medicine, and other life-sustaining supplies required to maintain the health and performance readiness of astronauts. A variety of biological platforms, such as plants and microbes, are of interest alone or in combination with current technologies. We’re interested in a variety of biological platforms that result in radically new ways to produce the necessary products to nourish future crews and keep them physically and mentally healthy during and after exploration class missions. 

Learn more about TRISH scientific initiatives in our Broad Institute Announcement (BIA):

BIA: TRISH Scientific Initiatives

Commercial Spaceflight


TRISH commercial space human health research addresses a wide range of challenges that humans face on long duration space missions: early detection and treatment of medical conditions, protection from radiation effects, mental health, team dynamics and more.


TRISH Innovations


View a collection of project highlights from TRISH’s completed research portfolio, which address many of NASA’s health risks for deep space exploration.

Case Studies