Center for Space Medicine

Translational Research Institute for Space Health Publications



Kaplonek P, Wang C, Bartsch Y, Fischinger S, Gorman MJ, Bowman K, et al. Early cross-coronavirus reactive signatures of protective humoral immunity against COVID-19. bioRxiv. 2021. DOI

Wong MC, Ng BK, Tian I, Sobhiyeh S, Pagano I, Dechenaud M, et al. A pose-independent method for accurate and precise body composition from 3D optical scans. Obesity (Silver Spring). 2021. DOI

Song Y, Wright JG, Anderson MJ, Rajendran S, Ren Z, Hua DH, et al. Quantitative Detection of Cathepsin B Activity in Neutral pH Buffers Using Gold Microelectrode Arrays: Toward Direct Multiplex Analyses of Extracellular Proteases in Human Serum. ACS Sens. 2021. DOI

J. Tyson McDonald FJE, Deanne Taylor, Robert J. Griffin, Waldemar Priebe, Mark R. Emmett, Mohammad M. Sajadi, Anthony D. Harris, Jean Clement, Joseph M. Dybas, Nukhet Aykin-Burns, Joseph W. Guarnieri, Larry N. Singh, Peter Grabham, Stephen B. Baylin, Aliza Yousey, Andrea N. Pearson, Peter M. Corry, Amanda Saravia-Butler, Thomas R. Aunins, Sadhana Sharma, Prashant Nagpal, Cem Meydan, Jonathan Foox, Christopher Mozsary, Bianca Cerqueira, Viktorija Zaksas, Urminder Singh, Eve Syrkin Wurtele, Sylvain V. Costes, Gustavo Gastão Davanzo, Diego Galeano, Alberto Paccanaro, Suzanne L. Meinig, Robert S. Hagan, Natalie M. Bowman, Matthew C. Wolfgang, Selin Altinok, Nicolae Sapoval, Todd J. Treangen, Pedro M. Moraes-Vieira, Charles Vanderburg, Douglas C. Wallace, Jonathan Schisler, Christopher E. Mason, Anushree Chatterjee, Robert Meller, Afshin Beheshti,. Role of miR-2392 in Driving SARS-CoV-2 Infection. Cell Reports 2021. DOI

Vunjak-Novakovic G, Ronaldson-Bouchard K, Radisic M. Organs-on-a-chip models for biological research. Cell. 2021;184(18):4597-611. DOI

Minqiang Wang YY, Wei Gao  Laser-engraved graphene for flexible and wearable electronics. Trends in Chemistry. 2021. DOI

Kahlenberg ZB, Carroll DJ, Cristea O, Urquieta E, Bissada NK, Jones JA. Urologic Innovation in the Spaceflight Environment: Challenges, Opportunities, and Future Directions. Medical Research Archives. 2021;9(9). DOI

Matthew J. McNulty, Yongao (Mary) Xiong, Kevin Yates, Kalimuthu Karuppanan, Jacob M. Hilzinger, Aaron J. Berliner, Jesse Delzio, Adam P. Arkin, Nancy E. Lane, Somen Nandi & Karen A. McDonald (2021): Molecular pharming to support human life on the moon, mars, and beyond, Critical Reviews in Biotechnology, DOI

Zheng, M., Domanskyi, S., Piermarocchi, C. et al. Visibility graph based temporal community detection with applications in biological time series. Sci Rep 11, 5623 (2021). DOI

Sophie C. Rosahl, Claudia Covarrubias, Jimmy H. Wu, and Emmanuel Urquieta.Therapeutic Hypothermia and Temperature Management. Ahead of print. DOI

Allaway, H.C.M., Pierson, R.A., Invik, J. et al. A rodent model of human dose-equivalent progestin-only implantable contraception. Reprod Biol Endocrinol 19, 47 (2021). DOI

Voros JL, Sherman SO, Rise R, Kryuchkov A, Stine P, Anderson AP and Clark TK. Galvanic Vestibular Stimulation Produces Cross-Modal Improvements in Visual Thresholds. Front Neurosci. 2021 Mar 31;15:640984. DOI

Swinton C,  Kiffer F, McElroy T, Wang J, Sridharan V, Boerma M, Allen A. Effects of 16O charged-particle irradiation on cognition, hippocampal morphology and mutagenesis in female mice. Behav Brain Res. 2021 Jun 11;407:113257. DOI.

Davis C, Allen A and Bowles DE. Consequences of space radiation on the brain and cardiovascular system. 2021, Journal of Environmental Science and Health, Part C, 39:2, 180-218, DOI

Tu J and Gao W. Ethical Considerations of Wearable Technologies in Human Research. Adv Healthc Mater. 2021 Apr 18;e2100127. DOI

Chancellor J, Nowadly C,Williams J, Aunon-Chancellor S, Chesal M, Looper J and Newhauser W. 2021 Everything you wanted to know about space radiation but were afraid to ask, Journal of Environmental Science and Health, Part C, 39:2, 113-128, DOI

Willey J, Britten RA, Blaber E, Tahimic CGT, Chancellor J, Mortreux M, Sanford L, Kubik AJ, Delp MD and Mao XW. 2021. The individual and combined effects of spaceflight radiation and microgravity on biologic systems and functional outcomes, Journal of Environmental Science and Health, Part C, 39:2, 129-179. DOI

LaPelusa M, Donoviel D, Branzini SE, Carlson PE, Jr., Culler S, Cheema AK, et al. Microbiome for Mars: surveying microbiome connections to healthcare with implications for long-duration human spaceflight, virtual workshop, July 13, 2020. Microbiome. 2021;9(1):2. DOI.

Mias GI, Singh VV, Rogers LRK, Xue S, Zheng M, Domanskyi S, Kanada M, Piermarocchi C, He J. Longitudinal saliva omics responses to immune perturbation: a case study. Sci Rep. 2021 Jan 12;11(1):710. DOI.

Penninckx S, Pariset E, Acuna AU, Lucas S, Costes SV. Considering Cell Proliferation to Optimize Detection of Radiation-Induced 53BP1 Positive Foci in 15 Mouse Strains Ex Vivo. Radiat Res. 2021;195(1):47-59. DOI.

Rosahl SC, Covarrubias C, Wu JH, Urquieta E. Staying Cool in Space: A Review of Therapeutic Hypothermia and Potential Application for Space Medicine. Ther Hypothermia Temp Manag. 2021. DOI.

Sapoval N, Mahmoud M, Jochum M, Liu Y, Elworth RAL, Wang Q, Albin D, Ogilvie H, Lee MD, Villapol S, Hernandez K, Maljkovic Berry I, Foox J, Beheshti A, Ternus K, Aagaard K, Posada D, Mason C, Sedlazeck FJ, Treangen TJ. Hidden genomic diversity of SARS-CoV-2: implications for qRT-PCR diagnostics and transmission. Genome Res. 2021. Epub ahead of print. DOI.

Bartsch YC, Fischinger S, Siddiqui SM, Chen Z, Yu J, Gebre M, et al. Discrete SARS-CoV-2 antibody titers track with functional humoral stability. Nature Communications. 2021;12(1):1018. DOI.

Eller KA, Aunins TR, Courtney CM, Campos JK, Otoupal PB, Erickson KE, et al. Facile accelerated specific therapeutic (FAST) platform develops antisense therapies to counter multidrug-resistant bacteria. Communications Biology. 2021;4(1):331. DOI.

Fan S, Inam ME, Peña D, Chen PR, Giancardo L, editors. X-Ray Based Automatic Detection Of Brain Coil Compaction Using Unsupervised Learning. 2021 IEEE 18th International Symposium on Biomedical Imaging (ISBI). 2021. DOI.

Gómez ML, Huang X, Alvarez D, He W, Baysal C, Zhu C, et al. Contributions of the international plant science community to the fight against human infectious diseases – part 1: epidemic and pandemic diseases. Plant Biotechnology Journal. 2021. DOI.

He W, Baysal C, Gómez ML, Huang X, Alvarez D, Zhu C, et al. Contributions of the international plant science community to the fight against infectious diseases in humans – part 2: affordable drugs in edible plants for endemic and re‐emerging diseases. Plant Biotechnology Journal. 2021. DOI.

Kaplonek P, Fischinger S, Cizmeci D, Bartsch YC., Kang J, Burke JS., Shin SA, Dayal D, Martin P, Mann C, Fatima A, Julg B, Nilles E,. Musk ER, Menon AS,. Krammer F, Saphire EO, Carfi A, and Alter G. Resilient Fc-Effector Functions Across SARS-CoV-2 Variants of Concern Following mRNA-1273 Vaccination. Immunity. 2021. DOI.

Lee W, Weisholtz DS, Strangman GE, Yoo S-S. Safety Review and Perspectives of Transcranial Focused Ultrasound Brain Stimulation. Brain & Neurorehabilitation. 2021;14(1). DOI.

Mitchell R, Frederick NE, Holzman ER, Agobe F, Allaway HCM, Bagher P. Ifetroban Reduces Coronary Artery Dysfunction in a Mouse Model of Duchenne Muscular Dystrophy. AJP Heart and Circulatory Physiology. 2021. DOI.

Nguyen J, Lin Y-Y, Gerecht S. The next generation of endothelial differentiation: Tissue-specific ECsCell Stem Cell. 2021. DOI.

Reynolds R, Little MP, Day S, Charvat J, Blattnig S, Huff J, et al. Cancer incidence and mortality in the USA Astronaut Corps, 1959–2017. Occupational and Environmental Medicine. 2021:oemed-2020. DOI.

Silverman JD, Bloom RJ, Jiang S, Durand HK, Dallow E, Mukherjee S, et al. “Measuring and mitigating PCR bias in microbiota datasets.” PLOS Computational Biology. 2021;17(7):e1009113. DOI.

Stewart JJ, Adams WW, López-Pozo M, Doherty Garcia N, McNamara M, Escobar CM, et al. Features of the Duckweed Lemna That Support Rapid Growth under Extremes of Light Intensity. Cells. 2021;10(6):1481. DOI.

Sujit SJ, Bonfante E, Aein A, Coronado I, Riascos-Castaneda R, Giancardo L. Deep Learning Enabled Brain Shunt Valve Identification Using Mobile Phones. Computer Methods and Programs in Biomedicine. 2021:106356. DOI.

Silverman JD, Bloom RJ, Jiang S, Durand HK, Dallow E, Mukherjee S, et al. Measuring and mitigating PCR bias in microbiota datasets. PLOS Computational Biology. 2021;17(7):e1009113. DOI.

Juhl OJ, Buettmann EG, Friedman MA, DeNapoli RC, Hoppock GA, Donahue HJ. Update on the effects of microgravity on the musculoskeletal system. npj Microgravity. 2021;7(1):28. DOI.


Worman ZF, Dempsey R, Domingo C, Donoviel D. NASA-backed launch for jobless postdocs. Nature. 2020; 587(197). DOI.

Kiffer F, Alexander T, Anderson J, Groves T, McElroy T, Wang J, et al. Late Effects of (1)H + (16)O on Short-Term and Object Memory, Hippocampal Dendritic Morphology and Mutagenesis. Front Behav Neurosci. 2020;14:96. DOI.

Anderson MJ, Song Y, Fan H, Wright JG, Ren Z, Hua DH, et al. Simultaneous, multiplex quantification of protease activities using a gold microelectrode array. Biosens Bioelectron. 2020;165:112330. DOI.

J. Voros et al., "Multi-modal Stochastic Resonance to Enhance Astronaut Perceptual Performance: Experimental Design," 2020 IEEE Aerospace Conference, Big Sky, MT, USA, 2020, pp. 1-8. DOI.

Sapoval N, Mahmoud M, Jochum MD, Liu Y, Elworth RAL, Wang Q, et al. Hidden genomic diversity of SARS-CoV-2: implications for qRT-PCR diagnostics and transmission. bioRxiv. 2020. DOI.

Paul AM, Cheng-Campbell M, Blaber EA, Anand S, Bhattacharya Sharmila, Zwart S, et al. Beyond Low-Earth Orbit: Characterizing the Immune Profile Following Simulated Spaceflight Conditions for Deep Space Missions. Cell Press. 2020. DOI.

Wuu Y, Hu B, Okunola H, Paul AM, Blaber EA, Cheng-Campbell M, et al. LET Dependent Low Dose and Synergistic Inhibition of Human Angiogenesis by Charged Particles: Validation of Mi RNAs that Drive Inhibition. Cell Press. 2020 DOI.

Malkani S, Cekanaviciute E, Mortreux M, Okunola H, Tarbier M, Schreurs A, et al. Circulating miRNA Signature Predicts and Rescues Spaceflight Associated Health Risks. Cell Press. 2020. DOI.

Wuu Y, Hu B, Okunola H, Paul AM, Blaber EA, Cheng-Campbell M, et al. LET-Dependent Low Dose and Synergistic Inhibition of Human Angiogenesis by Charged Particles: Validation of miRNAs that Drive Inhibition. iScience. 2020; 23(12):epub. DOI.

Malkani S, Chin CR, Cekanaviciute E, Mortreux M, Okinula H, Tarbier M, et al. Circulating miRNA Spaceflight Signature Reveals Targets for Countermeasure Development. Cell Rep. 2020;33(10):108448. DOI.

Paul AM, Cheng-Campbell M, Blaber EA, Anand S, Bhattacharya S, Zwart SR, et al. Beyond Low-Earth Orbit: Characterizing Immune and microRNA Differentials following Simulated Deep Spaceflight Conditions in Mice. iScience. 2020;23(12):101747. DOI.

Holmes ZC, Silverman JD, Dressman HK, Wei Z, Dallow EP, Armstrong SC, et al. Short-Chain Fatty Acid Production by Gut Microbiota from Children with Obesity Differs According to Prebiotic Choice and Bacterial Community Composition. mBio. 2020;11(4). DOI.

Silverman JD, Roche K, Mukherjee S, David LA. Naught all zeros in sequence count data are the same. Comput Struct Biotechnol J. 2020;18:2789-98. DOI.

Villa MM, Bloom RJ, Silverman JD, Durand HK, Jiang S, Wu A, et al. Interindividual Variation in Dietary Carbohydrate Metabolism by Gut Bacteria Revealed with Droplet Microfluidic Culture. mSystems. 2020;5(3). DOI.

Demmig-Adams B, Lopez-Pozo M, Stewart JJ, Adams WW, 3rd. Zeaxanthin and Lutein: Photoprotectors, Anti-Inflammatories, and Brain Food. Molecules. 2020;25(16). DOI.

Stewart JJ, Adams WW, 3rd, Escobar CM, Lopez-Pozo M, Demmig-Adams B. Growth and Essential Carotenoid Micronutrients in Lemna gibba as a Function of Growth Light Intensity. Front Plant Sci. 2020;11:480. DOI.

Demmig-Adams B, Stewart JJ, Lopez-Pozo M, Polutchko SK, Adams WW, 3rd. Zeaxanthin, a Molecule for Photoprotection in Many Different Environments. Molecules. 2020;25(24). DOI.

Dmochowski GM, Shereen AD, Berisha D, Dmochowski JP. Near-Infrared Light Increases Functional Connectivity with a Non-thermal Mechanism. Cerebral Cortex Communications. 2020;1(1). DOI.

Friedman MA, Abood A, Senwar B, Zhang Y, Maroni CR, Ferguson VL, et al. Genetic Variability affects the Skeletal Response to Unloading. bioRxiv. 2020:2020.06.26.174326. DOI.

Min J, Sempionatto JR, Teymourian H, Wang J, Gao W. Wearable electrochemical biosensors in North America. Biosens Bioelectron. 2021;172:112750. DOI.

Song Y, Min J, Yu Y, Wang H, Yang Y, Zhang H, et al. Wireless battery-free wearable sweat sensor powered by human motion. Sci Adv. 2020;6(40). DOI.

Torrente-Rodriguez RM, Lukas H, Tu J, Min J, Yang Y, Xu C, et al. SARS-CoV-2 RapidPlex: A Graphene-Based Multiplexed Telemedicine Platform for Rapid and Low-Cost COVID-19 Diagnosis and Monitoring. Matter. 2020;3(6):1981-98. DOI.

Lukas H, Xu C, Yu Y, Gao W. Emerging Telemedicine Tools for Remote COVID-19 Diagnosis, Monitoring, and Management. ACS Nano. 2020;14(12):16180-93. DOI.

Scott RA, Tarver WJ, Brunstetter TJ, Urquieta E. Optic Nerve Tortuosity on Earth and in Space. Aerosp Med Hum Perform. 2020;91(2):91-7. DOI

McDonald KA, Holtz RB. From Farm to Finger Prick-A Perspective on How Plants Can Help in the Fight Against COVID-19. Front Bioeng Biotechnol. 2020;8:782. DOI.

Yashar M, Marquez J, Menon J, Torron I, editors. Preliminary Design of an 'Autonomous Medical Response Agent' Interface Prototype for Long-Duration Spaceflight2020; Cham: Springer International Publishing. DOI.

Mias GI, Singh VV, Rogers LRK, Xue S, Zheng M, Domanskyi S, et al. Longitudinal Saliva Omics Responses to Immune Perturbation: A Case Study. bioRxiv. 2020:2020.06.16.156133. DOI.

Domanskyi S, Piermarocchi C, Mias GI. PyIOmica: longitudinal omics analysis and trend identification. Bioinformatics. 2020;36(7):2306-7. DOI.

Zheng M, Domanskyi S, Piermarocchi C, Mias GI. Visibility Graph Based Community Detection for Biological Time Series. bioRxiv. 2020:2020.03.02.973263. DOI.

Norsk P. Adaptation of the cardiovascular system to weightlessness: Surprises, paradoxes and implications for deep space missions. Acta Physiol (Oxf). 2020;228(3):e13434. DOI

Shelhamer M, Bloomberg J, LeBlanc A, Prisk GK, Sibonga J, Smith SM, et al. Selected discoveries from human research in space that are relevant to human health on Earth. NPJ Microgravity. 2020;6:5. DOI

Pariset E, Penninckx S, Kerbaul CD, Guiet E, Macha AL, Cekanaviciute E, et al. 53BP1 Repair Kinetics for Prediction of In Vivo Radiation Susceptibility in 15 Mouse Strains. Radiat Res. 2020;194(5):485-99. DOI

Almeida-Porada G, Atala AJ, Porada CD. Therapeutic Mesenchymal Stromal Cells for Immunotherapy and for Gene and Drug Delivery. Mol Ther Methods Clin Dev. 2020;16:204-24. DOI.

Reynolds R, Little MP, Day SM, Charvat J, Blatting S, Huff JL,  et al. Cancer Incidence and Mortality in the U.S. Astronaut Corps, 1959-2017. Res Square. 2020. DOI.

Riccio G, Au R, Emmerik Rv, Eslami M. Situated Precision Healthcare in the Smart Medical Home: Bringing NASA's Research Strategy down to Earth. Advances in Geriatric Medicine and Research. 2020;2(3):e200017. DOI.

Badran BW, Caulfield KA, Lopez JW, Cox C, Stomberg-Firestein S, DeVries WH, et al. Personalized TMS helmets for quick and reliable TMS administration outside of a laboratory setting. Brain Stimul. 2020;13(3):551-3. DOI.

Badran BW, Caulfield KA, Cox C, Lopez JW, Borckardt JJ, DeVries WH, et al. Brain stimulation in zero gravity: transcranial magnetic stimulation (TMS) motor threshold decreases during zero gravity induced by parabolic flight. NPJ Microgravity. 2020;6:26. DOI.

Caulfield KA, Lopez JW, Cox CE, Roberts DR, McTeague LM. A new, open-source 3D-printed transcranial magnetic stimulation (TMS) coil tracker holder for double blind, sham-controlled neuronavigation studies. Brain Stimul. 2020;13(3):600-2. DOI

Rasmussen JC, Kwon S, Pinal A, Bareis A, Velasquez FC, Janssen CF, et al. Assessing lymphatic route of CSF outflow and peripheral lymphatic contractile activity during head-down tilt using near-infrared fluorescence imaging. Physiol Rep. 2020;8(4):e14375. DOI.

Urbaniak C, Wong S, Tighe S, Arumugam A, Liu B, Parker CW, et al. Validating an Automated Nucleic Acid Extraction Device for Omics in Space Using Whole Cell Microbial Reference Standards. Front Microbiol. 2020;11:1909. DOI.

Vimal VP, Zheng H, Hong P, Fakharzadeh LN, Lackner JR, DiZio P. Characterizing Individual Differences in a Dynamic Stabilization Task Using Machine Learning. Aerosp Med Hum Perform. 2020;91(6):479-88. DOI.

Patel ZS, Brunstetter TJ, Tarver WJ, Whitmire AM, Zwart SR, Smith SM, et al. Red risks for a journey to the red planet: The highest priority human health risks for a mission to Mars. NPJ Microgravity. 2020;6(1):33. DOI.

Hammel P, Marchetti A, Zenhausern F. AR222, AR249, AS274, AS702 and AS708 antibodies recognize the spike S protein from SARS-CoV-2 by ELISA. Antib Rep. 2020;3(4):e220. DOI

Lacombe J, Zenhausern F, Cosson P. AI334, AQ806, AR222, AR249, AS274, AS708, RB572, RB574 and RB596 antibodies recognize SARS-CoV-2 viral particles by dot blot. Antib Rep. 2020;3(4):e273. DOI.

Hammel P, Zenhausern F. RB620 and RB621 antibodies recognize a peptide of the SARS-CoV-2 E protein by ELISA. Antib Rep. 2020;3(4):e238. DOI

Marchetti A, Zenhausern F. AR222, AR249, AS274, AS702 and AS708 antibodies recognize the spike S protein from SARS-CoV-2 by immunofluorescence. Antib Rep. 2020;3(4):e228. DOI

Marchetti A, Zenhausern F. RB572, RB574 and RB576 antibodies recognize the membrane M protein from SARS-CoV-2 by immunofluorescence. Antib Rep. 2020;3(4):e231. DOI

Marchetti A, Zenhausern F. The RB621 antibody recognizes the envelope E protein from SARS-CoV-2 by immunofluorescence. Antib Rep. 2020;3(4):e239. DOI

Pariset E, Bertucci A, Petay M, Malkani S, Lopez Macha A, Paulino Lima IG, et al. DNA Damage Baseline Predicts Resilience to Space Radiation and Radiotherapy. Cell Rep. 2020;33(10):108434. DOI.


Kiffer F, Boerma M, Allen A. Behavioral effects of space radiation: A comprehensive review of animal studies. Life Sci Space Res (Amst). 2019;21:1-21. DOI.

Levy M, Bertram JR, Eller KA, Chatterjee A, Nagpal P. Near-Infrared-Light-Triggered Antimicrobial Indium Phosphide Quantum Dots. Angew Chem Int Ed Engl. 2019;58(33):11414-8. DOI

Silverman JD, Bloom RJ, Jiang S, Durand HK, Mukherjee S, David LA. Measuring and Mitigating PCR Bias in Microbiome Data. bioRxiv. 2019:604025. DOI.

Villa MM, Bloom RJ, Silverman JD, Durand HK, Jiang S, Wu A, et al. High-throughput isolation and culture of human gut bacteria with droplet microfluidics. bioRxiv. 2019:630822. DOI.

Strangman G, Sawyer A, Fabre K, Urquieta E, Hury J, Wu J, et al. Deep-space applications for point-of-care technologies. Current Opinion in Biomedical Engineering. 2019;11:45-50. DOI.

Jimenez M, Langer R, Traverso G. Microbial therapeutics: New opportunities for drug delivery. J Exp Med. 2019;216(5):1005-9. DOI.

Marshall-Goebel K, Damani R, Bershad EM. Brain Physiological Response and Adaptation During Spaceflight. Neurosurgery. 2019;85(5):E815-E21. DOI.

Marshall-Goebel K. Neuro-ocular Effects of Spaceflight. In: Pathak Y, Araújo dos Santos M, Zea L, editors. Handbook of Space Pharmaceuticals. Cham: Springer International Publishing; 2019. p. 1-11. DOI.

Zhu B, Kwon S, Rasmussen JC, Litorja M, Sevick-Muraca EM. Comparison of NIR Versus SWIR Fluorescence Image Device Performance Using Working Standards Calibrated With SI Units. IEEE Trans Med Imaging. 2020;39(4):944-951. DOI.

Vimal VP, DiZio P, Lackner JR. Learning and long-term retention of dynamic self-stabilization skills. Exp Brain Res. 2019;237(11):2775-87. DOI.


Silverman JD, Durand HK, Bloom RJ, Mukherjee S, David LA. Dynamic linear models guide design and analysis of microbiota studies within artificial human guts. Microbiome. 2018;6(1):202. DOI.