Center for Space Medicine

TRISH Publications




Pachade S, Coronado I, Abdelkhaleq R, Yan J, Salazar-Marioni S, Jagolino A, et al. Detection of Stroke with Retinal Microvascular Density and Self-Supervised Learning Using OCT-A and Fundus Imaging. J Clin Med. 2022;11(24). DOI

H-C, Lee W, Kowsari K, Weisholtz DS, Yoo S-S. Effects of focused ultrasound pulse duration on stimulating cortical and subcortical motor circuits in awake sheep. PLOS ONE. 2022;17(12):e0278865. DOI

Puscas M, Martineau G, Bhella G, Bonnen PE, Carr P, Lim R, et al. Rare diseases and space health: optimizing synergies from scientific questions to care. NPJ Microgravity. 2022;8(1):58. DOI

Simmons P, Trujillo M, McElroy T, Binz R, Pathak R, Allen AR. Evaluating the effects of low-dose simulated galactic cosmic rays on murine hippocampal-dependent cognitive performance. Frontiers in Neuroscience. 2022;16. DOI

Peng M, Curry SM, Liu Y, Lohawala H, Sharma G, Sharma TP. The ex vivo human translaminar autonomous system to study spaceflight associated neuro-ocular syndrome pathogenesis. NPJ Microgravity. 2022;8(1):44. DOI

Pohlen M, Carroll D, Kim Prisk G, Sawyer AJ. Overview of Lunar Dust Toxicity Risk. NPJ Microgravity. 2022;8(1):55. DOI

Sempionatto JR, Lasalde-Ramírez JA, Mahato K, Wang J, Gao W. Wearable chemical sensors for biomarker discovery in the omics era. Nature Reviews Chemistry. 2022;6(12):899-915. DOI

Smith T, Peterman A, Donoviel D. Exponential Medicine: Challenges of Human Spaceflight Bringing Innovations for Earth — A Case Study. In: Friebe M, editor. Novel Innovation Design for the Future of Health: Entrepreneurial Concepts for Patient Empowerment and Health Democratization. Cham: Springer International Publishing; 2022. p. 71-8. DOI

Polutchko SK, Stewart JJ, McNamara M, Doherty Garcia N, López-Pozo M, Adams WW, et al. Lemna as a Sustainable, Highly Nutritious Crop: Nutrient Production in Different Light Environments. Nutraceuticals. 2022;2(4):350-64. DOI

Antonsen E, Monti, A, Charvat, J, Connell, ES, Reynolds, RJ, Abukmail, A, Marotta, K, Brown, C. Directed Acyclic Graphs: A Tool for Understanding the NASA Human Spaceflight System Risks - Human System Risk Board. NASA Technical Reports Server2022. Lin

Xue S, Rogers LRK, Zheng M, He J, Piermarocchi C, Mias GI. Applying differential network analysis to longitudinal gene expression in response to perturbations. Frontiers in Genetics. 2022;13. DOI

Cope H, Willis CRG, MacKay MJ, Rutter LA, Toh LS, Williams PM, et al. Routine omics collection is a golden opportunity for European human research in space and analog environments. Patterns (N Y). 2022;3(10):100550. DOI

Nguyen CN, Urquieta E. Contemporary review of dermatologic conditions in space flight and future implications for long-duration exploration missions. Life Sciences in Space Research. 2022. DOI

Gaidica M, Dantzer B. An implantable neurophysiology platform: Broadening research capabilities in free-living and non-traditional animals. Frontiers in Neural Circuits. 2022;16. DOI

Schimmoller BJ, Trovão NS, Isbell M, Goel C, Heck BF, Archer TC, et al. COVID-19 Exposure Assessment Tool (CEAT): Exposure quantification based on ventilation, infection prevalence, group characteristics, and behavior. Sci Adv. 2022;8(39):eabq0593. DOI

Simmons P, Corley C, Allen AR. Fractionated Proton Irradiation Does Not Impair Hippocampal-Dependent Short-Term or Spatial Memory in Female Mice. Toxics. 2022;10(9). DOI

Burian BK, Ebnali M, Robertson JM, Musson D, Pozner CN, Doyle T, et al. Using extended reality (XR) for medical training and real-time clinical support during deep space missions. Appl Ergon. 2023;106:103902. DOI

Evans AC, Martin KA, Saxena M, Bicher S, Wheeler E, Cordova EJ, et al. Curcumin Nanodiscs Improve Solubility and Serve as Radiological Protectants against Ionizing Radiation Exposures in a Cell-Cycle Dependent Manner. Nanomaterials (Basel). 2022;12(20). DOI

Liao S, Macharoen K, McDonald KA, Nandi S, Paul D. Analysis of Variability of Functionals of Recombinant Protein Production Trajectories Based on Limited Data. Int J Mol Sci. 2022;23(14). DOI

Xiong Y, Hirano H, Lane NE, Nandi S, McDonald KA. Plant-based production and characterization of a promising Fc-fusion protein against microgravity-induced bone density loss. Frontiers in Bioengineering and Biotechnology. 2022;10. DOI

Yarbrough D, Gerecht S. Engineering Smooth Muscle to Understand Extracellular Matrix Remodeling and Vascular Disease. Bioengineering. 2022;9(9):449. DOI

Liu Q, Jimenez M, Inda ME, Riaz A, Zirtiloglu T, Chandrakasan AP, et al. A Threshold-Based Bioluminescence Detector With a CMOS-Integrated Photodiode Array in 65 nm for a Multi-Diagnostic Ingestible Capsule. IEEE Journal of Solid-State Circuits. 2022:1-14. DOI

Reynolds RJ, Scot RT, Turner RT, Iwaniec UT, Bouxsein ML, et al. Validating Casual Diagrams of Human Health Risks for Spaceflight: An Example Using Bone Data from Rodents. Biomedicines 2022, 10(9), 2187. DOI

McNerlin C, Guan F, Bronk L, Lei K, Grosshans D, Young DW, et al. Targeting hippocampal neurogenesis to protect astronauts’ cognition and mood from decline due to space radiation effects. Life Sciences in Space Research. 2022. DOI

Mao XW, Stanbouly S, Chieu B, Sridharan V, Allen AR, Boerma M. Low dose space radiation-induced effects on the mouse retina and blood-retinal barrier integrity. Acta Astronautica. 2022;199:412-9. DOI

Seidler RD, Stern C, Basner M, Stahn AC, Wuyts FL, Zu Eulenburg P. Future research directions to identify risks and mitigation strategies for neurostructural, ocular, and behavioral changes induced by human spaceflight: A NASA-ESA expert group consensus report. Front Neural Circuits. 2022;16:876789. DOI

Holmes ZC, Villa MM, Durand HK, Jiang S, Dallow EP, Petrone BL, et al. Microbiota responses to different prebiotics are conserved within individuals and associated with habitual fiber intake. Microbiome. 2022;10(1):114. DOI

Bokhari RS, Beheshti A, Blutt SE, Bowles DE, Brenner D, Britton R, et al. Looking on the horizon; potential and unique approaches to developing radiation countermeasures for deep space travel. Life Sciences in Space Research. 2022. DOI

McCollum CR, Courtney CM, O’Connor NJ, Aunins TR, Ding Y, Jordan TX, et al. Nanoligomers Targeting Human miRNA for the Treatment of Severe COVID-19 Are Safe and Nontoxic in Mice. ACS Biomaterials Science & Engineering. 2022;8(7):3087-106. DOI

Courtney CM, Sharma S, Fallgren C, Weil MM, Chatterjee A, Nagpal P. Reversing radiation-induced immunosuppression using a new therapeutic modality. Life Sciences in Space Research. 2022. DOI

Madrigal P, Singh NK, Wood JM, Gaudioso E, Hernández-Del-Olmo F, Mason CE, et al. Machine learning algorithm to characterize antimicrobial resistance associated with the International Space Station surface microbiome. Microbiome. 2022;10(1):134. DOI

Sharma A, Clemens RA, Garcia O, Taylor DL, Wagner NL, Shepard KA, et al. Biomanufacturing in low Earth orbit for regenerative medicine. Stem Cell Reports. 2022;17(1):1-13. DOI

Wang, M, Yang Y, Min J, Song Y, Tu J, Mukasa D, et al. A Wearable Electrochemical Biosensor for the Monitoring of Metabolites and Nutrients. Nat Biomed Eng. 2022 Aug 15. DOI

Brojakowska A, Kour A, Thel MC, Park E, Bisserier M, et al. Retrospective Analysis of Somatic Mutations and Clonal Hematopoiesis in Astronauts. Commun Biol, 2022 Aug 17:5(1):828. DOI

Buettmann EG, Goldscheitter GM, Hoppock GA, Friedman MA, Suva LJ, Donahue HJ. Similarities Between Disuse and Age-Induced Bone Loss. J Bone Miner Res, 37: 1417-1434. DOI

Bisserier M, Brojakowska A, Saffran N, Kumar Rai A, Lee B, Coleman B, et al. Astronauts Plasma-Derived Exosomes Induced Aberrant EZH2-Mediated H3K27me3 Epigenetic Regulation of the Vitamin D Receptor. Front. Cardiovasc. Med. 16 June 2022. DOI

Yu Y, Li J, Solomon SA, Min J, Tu J, Guo W, et al. All-printed soft human-machine interface for robotic physicochemical sensing. Sci Robot. 2022;7(67):eabn0495. DOI

Schnellmann R, Ntekoumes D, Choudhury MI, Sun S, Wei Z, Gerecht S. Stiffening Matrix Induces Age-Mediated Microvascular Phenotype Through Increased Cell Contractility and Destabilization of Adherens Junctions. Adv Sci (Weinh). 2022:e2201483. DOI

Goukassian D, Arakelyan A, Brojakowska A, Bisserier M, Hakobyan S, Hadri L, et al. Space flight associated changes in astronauts' plasma-derived small extracellular vesicle microRNA: Biomarker identification. Clin Transl Med. 2022;12(6):e845. DOI 

Ayora-Talavera G, Kirstein OD, Puerta-Guardo H, Barrera-Fuentes GA, Ortegòn-Abud D, Che-Mendoza A, et al. SARS-CoV-2 antibody prevalence in a pediatric cohort of unvaccinated children in Mérida, Yucatán, México. PLOS Global Public Health. 2022;2(6):e0000354. DOI 

Hann EC, Overa S, Harland-Dunaway M, Narvaez AF, Le DN, Orozco-Cárdenas ML, et al. A hybrid inorganic–biological artificial photosynthesis system for energy-efficient food production. Nature Food. 2022;3(6):461-71. DOI

Tu D, Basner M, Smith MG, Williams ES, Ryder VE, Romoser AA, et al. Dynamic ensemble prediction of cognitive performance in spaceflight. Scientific Reports. 2022;12(1):11032. DOI

Bhattacharjee S, Liao S, Paul D, Chaudhuri S. Inference on the dynamics of COVID-19 in the United States. Sci Rep. 2022;12(1):2253. DOI

McNulty MJ, Schwartz A, Delzio J, Karuppanan K, Jacobson A, Hart O, et al. Affinity Sedimentation and Magnetic Separation With Plant-Made Immunosorbent Nanoparticles for Therapeutic Protein Purification. Front Bioeng Biotechnol. 2022;10:865481. DOI

McNulty MJ, Xiong YM, Yates K, Karuppanan K, Hilzinger JM, Berliner AJ, et al. Molecular pharming to support human life on the moon, mars, and beyond. Crit Rev Biotechnol. 2021;41(6):849-64. DOI

Bishawi M, Lee FH, Abraham DM, Glass C, Blocker SJ, Cox DJ, et al. Late onset cardiovascular dysfunction in adult mice resulting from galactic cosmic ray exposure. iScience. 2022;25(4):104086. DOI

Zhuang RZ, Lock R, Liu B, Vunjak-Novakovic G. Opportunities and challenges in cardiac tissue engineering from an analysis of two decades of advances. Nat Biomed Eng. 2022;6(4):327-38. DOI

Macklin BL, Lin YY, Emmerich K, Wisniewski E, Polster BM, Konstantopoulos K, et al. Intrinsic epigenetic control of angiogenesis in induced pluripotent stem cell-derived endothelium regulates vascular regeneration. NPJ Regen Med. 2022;7(1):28. DOI

Jamison DA, Jr., Anand Narayanan S, Trovao NS, Guarnieri JW, Topper MJ, Moraes-Vieira PM, et al. A comprehensive SARS-CoV-2 and COVID-19 review, Part 1: Intracellular overdrive for SARS-CoV-2 infection. Eur J Hum Genet. 2022. DOI

Kaplonek P, Cizmeci D, Fischinger S, Collier AR, Suscovich T, Linde C, et al. mRNA-1273 and BNT162b2 COVID-19 vaccines elicit antibodies with differences in Fc-mediated effector functions. Sci Transl Med. 2022;14(645):eabm2311. DOI

Cao X, Weil MM, Wu JC. Clinical Trial in a Dish for Space Radiation Countermeasure Discovery. Life Sciences in Space Research. 2022. DOI

Sempionatto JR, Gao W. Chapter 8 - Wearable chemosensors. In: Morales-Narvaez E, Dincer C, editors. Wearable Physical, Chemical and Biological Sensors: Elsevier; 2022. p. 219-34. DOI

Leung CM, de Haan P, Ronaldson-Bouchard K, Kim G-A, Ko J, Rho HS, et al. A guide to the organ-on-a-chip. Nature Reviews Methods Primers. 2022;2(1):33. DOI

Marshall-Goebel K. Neuro-ocular Effects of Spaceflight. In: Pathak YV, Araújo dos Santos M, Zea L, editors. Handbook of Space Pharmaceuticals. Cham: Springer International Publishing; 2022. p. 261-71. DOI

Nishiga M, Jahng JWS, Wu JC. Ferroptosis of Pacemaker Cells in COVID-19. Circ Res. 2022;130(7):978-80. DOI

Estrada UML, Meeks G, Salazar-Marioni S, Scalzo F, Farooqui M, Vivanco-Suarez J, et al. Quantification of infarct core signal using CT imaging in acute ischemic stroke. Neuroimage Clin. 2022;34:102998. DOI

Urquieta E, Wu J, Hury J, Donoviel D. Establishment of an open biomedical database for commercial spaceflight. Nat Med. 2022. DOI

Ronaldson-Bouchard K, Baldassarri I, Tavakol DN, Graney PL, Samaritano M, Cimetta E, et al. Engineering complexity in human tissue models of cancer. Adv Drug Deliv Rev. 2022;184:114181. DOI

McNulty MJ, Hamada N, Delzio J, McKee L, Nandi S, Longo ML, et al. Functionalizing silica sol–gel with entrapped plant virus-based immunosorbent nanoparticles. Journal of Nanobiotechnology. 2022;20(1):105. DOI

Lee W, Weisholtz DS, Strangman GE, Yoo S-S. Safety Review and Perspectives of Transcranial Focused Ultrasound Brain Stimulation. Brain Neurorehabil. 2021;14(1). DOI

Karlebach G, Aronow B, Baylin SB, Butler D, Foox J, Levy S, et al. Betacoronavirus-specific alternate splicing. Genomics. 2022;114(2):110270. DOI

Kaplonek P, Cizmeci D, Fischinger S, Collier A-r, Suscovich T, Linde C, et al. mRNA-1273 and BNT162b2 COVID-19 vaccines elicit antibodies with differences in Fc-mediated effector functions. Science Translational Medicine.0(0):eabm2311. DOI

Didier KD, Hammer SM, Alexander AM, Rollins KS, Barstow TJ. The acute effects of passive heating on endothelial function, muscle microvascular oxygen delivery, and expression of serum HSP90alpha. Microvasc Res. 2022;142:104356. DOI

Voros J, Rise R, Sherman S, Durell A, Anderson AP, Clark TK. A machine learning approach to identify stochastic resonance in human perceptual thresholds. J Neurosci Methods. 2022;374:109559. DOI

Kandel P, Semerci F, Mishra R, Choi W, Bajic A, Baluya D, et al. Oleic acid is an endogenous ligand of TLX/NR2E1 that triggers hippocampal neurogenesis. Proc Natl Acad Sci U S A. 2022;119(13):e2023784119. DOI

Finch E, Lowe R, Fischinger S, de St Aubin M, Siddiqui SM, Dayal D, et al. SARS-CoV-2 antibodies protect against reinfection for at least 6 months in a multicentre seroepidemiological workplace cohort. PLoS Biol. 2022;20(2):e3001531. DOI

Wang Y, Tang J, Vimal VP, Lackner JR, DiZio P, Hong P. Crash Prediction Using Deep Learning in a Disorienting Spaceflight Analog Balancing Task. Frontiers in Physiology. 2022;13. DOI

Siddiqui SM, Bowman KA, Zhu AL, Fischinger S, Beger S, Maron JS, et al. Serological Markers of SARS-CoV-2 Reinfection. mBio. 2022:e0214121. DOI

Pena D, Suescun J, Schiess M, Ellmore TM, Giancardo L, Alzheimer's Disease Neuroimaging I. Toward a Multimodal Computer-Aided Diagnostic Tool for Alzheimer's Disease Conversion. Front Neurosci. 2021;15:744190. DOI

Park J, Foox J, Hether T, Danko D, Warren S, Kim Y, et al. System-wide transcriptome damage and tissue identity loss in COVID-19 patients. Cell Reports Medicine. 2022:100522. DOI

Karlebach G, Aronow B, Baylin SB, Butler D, Foox J, Levy S, et al. Betacoronavirus-specific alternate splicing. Genomics. 2022;114(2):110270. DOI

Kaplonek P, Fischinger S, Cizmeci D, Bartsch YC, Kang J, Burke JS, et al. mRNA-1273 vaccine-induced antibodies maintain Fc effector functions across SARS-CoV-2 variants of concern. Immunity. 2022. DOI

DeNapoli R, Buettmann E, Donahue H. Cellular and Molecular Biology in Bone Remodeling. 2022. p. 3-15. DOI

Demmig-Adams B, Polutchko SK, Zenir MC, Fourounjian P, Stewart JJ, López-Pozo M, et al. Intersections: photosynthesis, abiotic stress, and the plant microbiome. Photosynthetica. 2022. DOI

Demmig-Adams B, Lopez-Pozo M, Polutchko SK, Fourounjian P, Stewart JJ, Zenir MC, et al. Growth and Nutritional Quality of Lemnaceae Viewed Comparatively in an Ecological and Evolutionary Context. Plants (Basel). 2022;11(2). DOI

Cromwell RL, Huff JL, Simonsen LC, Patel ZS. Earth-Based Research Analogs to Investigate Space-Based Health Risks. New Space. 2021;9(4):204-16. DOI

Bisserier M, Saffran N, Brojakowska A, Sebastian A, Evans AC, Coleman MA, et al. Emerging Role of Exosomal Long Non-coding RNAs in Spaceflight-Associated Risks in Astronauts. Frontiers in Genetics. 2022;12. DOI


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