The Process

For Physicians

• Make tailored phages that kill your patient’s specific drug-resistant bacterium
• Help with applying for an IND or emergency IND from the FDA
• Deliver phages that are safe, effective, and characterized For

For Healthcare Facilities

• Make tailored phages that kill drug-resistant bacteria circulating at your institution
• Formulate a strategy for biocontrol of bacteria in rooms, instruments, etc.

For Food Business

• Make tailored phages that kill bacteria that contaminate foodstuffs, including poultry and beef products
• Formulate the product to work best in the environment you need

For Industry

• Make phages that kill bacteria that foul, corrode, or contaminate your lines, equipment, or products
• Customize the phage for the conditions you need

For Healthcare Products

• Make phages that kill bacteria that contaminate your medicines, probiotics, or supplements
• Help keep your products safe by removing “bad” bacteria from the preparations

For Pet Health

• Make phages that kill bacteria that cause common pet ailments

Send us Your Strain

Give us the problematic bacterium or have us isolate it from the sample you provide.

Screen

We will screen our well-characterized library of therapeutic phages that kill many pathogenic species of bacteria.

Search

If we don’t have the phage, we will ask Mother Nature for help. In this phase, we search environmental reservoirs (soil, water, sewage, bodily fluids—you name it!) for phages that are effective against your strain.

Identify

We identify lead candidates, evaluate their effectiveness, and pick the best ones to purify.

Purify

We scale up, use several techniques to purify, and test the purity of the phage. This gives us a clear picture of the product for the next stage of development: Characterization.

Basic Services

• Basic characterization (titer, plaque size, plaque morphology)
• Efficiency of Plating (Host Range)
• Infection kinetics (adsorption rate, latent period, burst size)
• pH Sensitivity
• Endotoxin quantification1
• TEM Imaging*
• Whole genome sequencing*
• Standard genome annotation*

Premium Services

• Phage purification
• Full genome annotation*
• Genome curation*
• Sterility testing1
• Efficacy testing in blood, urine, stool, or other media*
• Efficacy testing in animal models*,2
• Microbiome editing*
• Biofilm disruption on catheters*
• Industrial applications (surfaces, fluids, etc.)*

* Should be performed with purified phage.

1 Tested in accredited and certified laboratories for FDA approval.

2 We have established murine models of sepsis/bacteremia, immunocompromised infections, UTI, granuloma, and microbiome gut editing. If we don’t already have it, we will develop it for you.

Example Report For Your Phange

Characteristics

Sequencing

Infection Kinetics

Formulation

Last Step

At this last step, we can hand over the final product.

We can deliver: 

• Phage(s) or phage cocktails designed to target your bacterial strain(s), formulated in whatever media you request.
• Chemical, manufacturing, and control information to verify the product’s safety, stability, and sterility.
• Quantifiable reports tailored to your project’s requests. (Example above)

Quickly Evolve Phange to Target Resistant Bacteria

Phages are small, but powerful killers of bacteria. This selective pressure may lead bacteria to evolve resistance and escape from phage, similar to antibiotic resistance. If this happens, TAILΦR can discover new phages or employ proprietary technology to evolve new phage that kill resistant bacteria.