Investigators below have their main faculty appointments within the Department of Molecular and Cellular Biology at Baylor College of Medicine.
Margaret A. Goodell, Ph.D.
Professor and Chair
Mechanisms that regulate normal and malignant hematopoiesis, particularly with regard to DNA methylation
Rachel Arey, Ph.D.
Molecular mechanisms of learning, memory, and complex behaviors. Molecular genetic analysis of genes involved in age-related cognitive decline
Rachel Arey Lab
Blair Benham-Pyle, Ph.D.
The Benham-Pyle lab uses the highly regenerative flatworm Schmidtea mediterranea to study stem cells, whole-body regeneration, and cancer prevention.
Andre Catic, M.D., Ph.D.
How protein quality control impacts transcription, translation, and metabolism with relevance to aging and cancer
Andre Catic Lab
Eric Chang, Ph.D.
Translational research on how estrogen receptor positive breast cancer cells acquire treatment resistance and turn metastatic
Eric Chang Lab
Xi Chen, Ph.D.
Function and mechanism of Endoplasmic Reticulum (ER) protein quality control machinery in cancer progression, metastasis and therapy resistance
Cristian Coarfa, Ph.D.
Achieving biological insight via integrative analysis, interpretation, and visualization of large scale multi-omics datasets, and enabling of scientific advancements via collaborative tools and computing platforms
Alan Davis, Ph.D.
Characterizing a new stem-like cell in bone that immediately proceeds the chondro-osseous progenitor that becomes both chondrocytes and osteoblasts
Alan Davis Lab
Bruno Di Stefano, Ph.D.
Understanding the post-transcriptional & epigenetic mechanisms that govern stem cell potency and cell fate decisions
Kyle Eagen, Ph.D.
Molecular mechanisms of DNA folding with a focus on how linear patterns of histone modifications impact three-dimensional chromosome structure
Kyle Eagen Lab
Dean Edwards, Ph.D.
Mechanism of action and structure analysis of steroid hormone receptors and role of progesterone receptors in mammary gland and breast cancer
ATC Core Labs
Richard Finnell, Ph.D.
In vivo and in vitro multi-dimensional models of neural tube closure defects and whole genome investigations of complex human birth defects
Richard Finnell Lab
Daniel Gorelick, Ph.D.
How environmental endocrine disrupting compounds, toxicants and pharmaceuticals influence embryonic development and cause congenital anomalies
Dan Gorelick Lab
Sang Han, Ph.D.
Molecular mechanism of nuclear receptors and nuclear receptor coactivators in female reproductive diseases progression
H. Courtney Hodges, Ph.D.
Mechanisms of ATP-dependent chromatin remodeling and transcription regulation. 3D models of cancer. Systems biology of SWI/SNF complexes.
H. Courtney Hodges Lab
Pengxiang Huang, Ph.D.
Role of lipids and mechanisms of signal transduction in the Hedgehog and Wnt pathways
William Hudson Ph.D.
Understanding the causes of T cell dysfunction in order to develop new immunotherapies for cancer and other diseases
Jason Lee, Ph.D.
Mechanisms and functions of contact sites between membrane-bound organelles and membrane-less organelles
Yi Li, Ph.D.
Molecular and cellular mechanisms of breast cancer initiation, progression and metastasis and cancer stem cells
Yi Li Lab
David Lonard, Ph.D.
Role of steroid receptor coactivators in the regulation of transcription and to develop inhibitors to target them
John Lydon, Ph.D.
Cellular and molecular mechanisms that enable embryo implantation into the endometrium to establish a pregnancy
Michael Mancini, Ph.D.
Professor and Core Director
Image-based single cell approaches to study ER/AR-mediated transcription by high content analysis (HCA) using numerous state-of-the-art platforms
Shailaja Mani, Ph.D.
Molecular mechanisms of steroid hormone action in brain function. Sex differences in stress neurobiology using omics approaches and mouse models.
Shailaja Mani Lab
Lisa McClendon, Ph.D.
Identify molecular and cellular signaling pathways involved in cardiac and brain tissue remodeling following ischemic injury
Neil McKenna, Ph.D.
Applying biocuration to archived 'omics datasets to mechanize cellular signaling pathways
Bert O'Malley, M.D.
TC Thompson Professor and Chancellor
Hormone action; receptor coactivators; 3-D structures of NR-CoA complexes; CoAs in metabolic, CVS, oncogenic diseases; CoAs as therapeutic targets
Ronald Parchem, Ph.D.
Stem cells and regenerative medicine; role of miRNAs in development and disease; environmental and genetic causes of birth defects
Frederick Pereira, Ph.D.
Understanding human auditory and neuronal function disorders; developing pharmacologic, gene or cell-based therapies relevant to aging and cancer
Nagireddy Putluri, Ph.D.
Metabolomic profiling of tumors to obtain biochemical insights into cancer progression
Nagireddy Putluri Lab
Josh Riback, Ph.D.
Biophysics of biological condensates; Role of condensates in forming RNP-complexes and reorganizing the cell in response to diverse stimuli
Joanne Richards, Ph.D.
Molecular mechanisms by which key signaling pathways regulate ovarian cell gene expression and alter cell fate decisions
Kevin Roarty, Ph.D.
Wnt pathway biology; mammary development; breast cancer heterogeneity and plasticity; collective migration; mechanisms of breast cancer metastasis
Kevin Roarty Lab
Jeffrey Rosen, Ph.D.
C.C. Bell Distinguished Professor of Molecular & Cellular Biology
Mammary gland development and breast cancer; Wnt and Fgf; translational regulation; immune microenvironment; epigenetic reprogramming of EMT
Jeffrey Rosen Lab
David Rowley, Ph.D.
Role of mesenchymal stem cells in the reactive stroma tumor microenvironment; osteogenic niche and progression of cancer to therapeutic resistance
Carolyn Smith, Ph.D.
Professor and Dean, Graduate School of Biomedical Sciences
Negative regulation of estrogen receptor function; ER and coactivator interactions; breast and bladder cancer; graduate education
Arun Sreekumar, Ph.D.
Metabolic re-wiring associated with prostate and breast cancer progression as well as in cancer health disparities
Arun Sreekumar Lab
Zheng Sun, Ph.D.
Neuroendocrine regulation of metabolism; epigenome and circadian clock in neurocognition; exercise, diet, and toxins in resilience
Zheng Sun Lab
Jeanine Van Nostrand, Ph.D.
Role of metabolic checkpoints triggered by AMPK and mTORC1 signaling in cancer and metabolic disease
Cheryl Walker, Ph.D.
Professor and Director, Center for Precision Environmental Health
Role of gene environment interactions in diseases such as cancer, fibroids and NAFLD. Effects of early environmental exposures on the epigenome
Cheryl Walker Lab
Margot Williams, Ph.D.
Molecular mechanisms of vertebrate embryogenesis using genetic, live imaging, and synthetic embryology approaches in zebrafish
Margot Williams Lab
Jianming Xu, Ph.D.
Gordon Cain Endowed Professorship in Cell Biology
Cell signaling and gene regulation mechanisms. Molecular and Cellular biology of steroid hormone promoted cancers. Gene editing in cells and mice
Feng Yang, Ph.D.
Pioneering MAPK4 biology in human cancers; signaling pathways regulating cancer and therapy-resistance; mouse models for cancers; tumor microenvironment
Feng Yang Lab
Ming Xiaoming Zhang, M.D., Ph.D.
Professor and Director of Anatomical Sciences
McGovern teaching-award winner. Director, Anatomical Sciences & Willed Body Programs. Course director, Schools of Medicine and Health Professions.
Xiang Zhang, Ph.D.
Professor and William T. Butler M.D. Endowed Chair
Breast cancer metastasis, bone microenvironment and metastasis, tumor immune microenvironment, resistance to immunotherapies, novel precision therapies
Xiang Zhang Lab