William Harris Hudson

Assistant Professor

Email

william.hudson@bcm.edu

Positions

Assistant Professor: Mol & Cell Biology
Baylor College of Medicine

Member: Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine

Addresses

BCM Michael DeBakey Center (Lab): Room M512E
Houston, TX, 77030
United States

Education

BS from Georgia Institute of Technology: Atlanta, GA

PhD from Emory University: Atlanta, GA

Professional Interests

Cancer immunology
Viral immunology
Immunotherapy
T cell biology
Bioinformatics

Professional Statement

T cells are responsible for destroying tumors and cells infected with intracellular pathogens such as viruses and bacteria. Unfortunately T cell responses are not always optimal, leading to chronic infections and the growth of tumors. My research focuses on understanding the causes of T cell dysfunction in order to develop new immunotherapies for cancer and other diseases.

Selected Publications

Sudmeier LJ, Hoang KB, Nduom EK, Wieland A, Neill SG, Schniederjan MJ, Ramalingam SS, Olson JJ, Ahmed R, Hudson WH. " Distinct phenotypic states and spatial distribution of CD8+ T cell clonotypes in human brain metastases " Cell Reports Medicine. 2022 ;
Pubmed PMID: 35584630.
Hudson WH, Prokhnevska N, Gensheimer J, Akondy R, McGuire DJ, Ahmed R, Kissick HT.. " Expression of novel long noncoding RNAs defines virus-specific effector and memory CD8+ T cells " Nature Communications. 2019 ;
Pubmed PMID: 30643116.
Hudson WH, Gensheimer J, Hashimoto M, Wieland A, Valanparambil RM, Li P, Lin J-X, Konieczny BT, Im SJ, Leonard WJ, Kissick HT, Ahmed R.. " Proliferating Transitory T Cells with an Effector-like Transcriptional Signature Emerge from PD-1+ Stem-like CD8+ T Cells during Chronic Infection " Immunity. 2019 ;
Pubmed PMID: 31810882.

Funding

CPRIT Recruitment of First-Time, Tenure-Track Faculty Members #RR220069: (09/01/2022 - 08/31/2025); Cancer Prevention and Research Institute of Texas

NIH Pathway to Independence Award #K99AI153736: (08/17/2020 - 07/31/2024); Grant funding from National Institutes of Health