Email

echang1@bcm.edu

Positions

Professor

Breast Center - Chang, E.
Baylor College of Medicine
Houston, TX, US

Member

Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas, United States

Education

Advanced Training from Cold Spring Harbor Laboratory

01/1992 - Cold Spring Harbor, NY, United States

Ph.D. from State University Of New York At Buffalo

01/1989 - Buffalo, NY, United States

B.S. from National Taiwan University

01/1981 - Taipei, China, Rep Of Taiwan

Websites

Selected Publications

• Chang EC, Barr M, Wang Y, Jung V, Xu HP, Wigler MH. " Cooperative interaction of S. pombe proteins required for mating and morphogenesis. " Cell. 1994 Oct 7; 79 (1) : 131-41.
  Pubmed PMID: 7923372.
• Yen HC, Gordon C, Chang EC. " Schizosaccharomyces pombe Int6 and Ras homologs regulate cell division and mitotic fidelity via the proteasome. " Cell. 2003 Jan 24; 112 (2) : 207-17.
  Pubmed PMID: 12553909.
• Sha Z, Brill LM, Cabrera R, Kleifeld O, Scheliga JS, Glickman MH, Chang EC, Wolf DA. " The eIF3 interactome reveals the translasome, a supercomplex linking protein synthesis and degradation machineries. " Mol. Cell. 2009 Oct 9; 36 (1) : 141-52.
  Pubmed PMID: 19818717.
• Zheng, Z. Y. Tian, L. Bu, W. Fan, C. Gao, X. Wang, H. Liao, Y. H. Li, Y. Lewis, M. T. Edwards, D. Zwaka, T. P. Hilsenbeck, S. G. Medina, D. Perou, C. M. Creighton, C. J. Zhang, X. H. Chang, E. C.. " Wild-Type N-Ras, Overexpressed in Basal-like Breast Cancer, Promotes Tumor Formation by Inducing IL-8 Secretion via JAK2 Activation " Cell Reports. 2018 ; 12 : 511-524.
  Pubmed PMID: 26166574.
• Zheng ZY, Anurag M, Lei JT, Cao J, Si ... Chen Y, Lavere P, Li J, Du XH, Cakar B, Song W, Kim BJ, Shi J, Seker S, Chan DW, Zhao GQ, Chen X, Banks KC, Lanman RB, Shafaee MN, Zhang XH, Vasaikar S, Zhang B, Hilsenbeck SG, Li W, Foulds CE, Ellis MJ, Chang EC. " Neurofibromin Is an Estrogen Receptor-alpha Transcriptional Co-repressor in Breast Cancer " Cancer Cell. 2020 ; 37 : 387-402.
  Pubmed PMID: 32142667.
• Zheng Z-Y, Chen A, Jaehnig EJ, Anurag M, Lei JT, Feng L, Wang C, Fandino D, Singh P, Kennedy H, Yadav G, Vollert CT, Tsai J, Chen X, Li Y, Lim B, Thompson A, Li S, Foulds CE, Zhang B, Ellis MJ, Chang EC:. " NF1-depleted ER+ breast cancers are differentially sensitive to CDK4/6 inhibitors.. " Sci. Transl. Med.. 2025 Aug 27; 17 : eadq5492.
• Zhao, Z. Zheng, Z. Y. Lei, J. T. Baik, M. J. Wu, Y. H. Somes, L. K. Mosquera Paternina, A. F. Harb, O. A. Chang, O. A. Liu, F. Holt, M. V. Wang, J. Bado, I. Wang, H. Miles, G. Gugala, Z. Anurag, M. Elkhanany, A. Li, Y. Hoyos, V. Zhang, X. H. Chang, E. C.. " NF1 loss in estrogen receptor-positive breast cancer induces osteoclast formation and immunosuppression to promote bone metastasis " Cancer Lett. 2026 ;
  Pubmed PMID: 42217562.

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Languages

Chinese (Mandarin)