Eric C Chang, Ph.D.

Professor

(713) 520-7828

Email

echang1@bcm.edu

Positions

Professor: Breast Center - Chang, E.
Baylor College of Medicine
Houston, TX, US

Member: Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas, United States

Education

Advanced Training from Cold Spring Harbor Laboratory: 01/1992 - Cold Spring Harbor, NY, United States

Ph.D. from State University Of New York At Buffalo: 01/1989 - Buffalo, NY, United States

B.S. from National Taiwan University: 01/1981 - Taipei, China, Rep Of Taiwan

Websites

Eric Chang-VIICTR

Info from VIICTR

Eric Chang Lab

Selected Publications

Chen CR, Chen J, Chang EC. " A conserved interaction between Moe1 and Mal3 is important for proper spindle formation in Schizosaccharomyces pombe. " Mol. Biol. Cell. 2000 Dec ; 11 (12) : 4067-77.
Pubmed PMID: 11102508.
Zheng ZY, Cheng CM, Fu XR, Chen LY, Xu L, Terrillon S, Wong ST, Bar-Sagi D, Songyang Z, Chang EC. " CHMP6 and VPS4A mediate the recycling of Ras to the plasma membrane to promote growth factor signaling. " Oncogene. 2012 Oct 25; 31 (43) : 4630-8.
Pubmed PMID: 22231449.
Cheng CM, Li H, Gasman S, Huang J, Schiff R, Chang EC. " Compartmentalized Ras Proteins Transform NIH 3T3 Cells with Different Efficiencies. " Mol. Cell. Biol.. 2011 Mar ; 31 (5) : 983-97.
Pubmed PMID: 21189290.
Onken B, Wiener H, Philips MR, Chang EC. " Compartmentalized signaling of Ras in fission yeast. " Proc. Natl. Acad. Sci. U.S.A.. 2006 Jun 13; 103 (24) : 9045-50.
Pubmed PMID: 16754851.
Chang EC, Barr M, Wang Y, Jung V, Xu HP, Wigler MH. " Cooperative interaction of S. pombe proteins required for mating and morphogenesis. " Cell. 1994 Oct 7; 79 (1) : 131-41.
Pubmed PMID: 7923372.
Li YC, Chen CR, Chang EC. " Fission yeast Ras1 effector Scd1 interacts with the spindle and affects its proper formation. " Genetics. 2000 Nov ; 156 (3) : 995-1004.
Pubmed PMID: 11063680.
Chang EC, Crawford BF, Hong Z, Bilinski T, Kosman DJ. " Genetic and biochemical characterization of Cu,Zn superoxide dismutase mutants in Saccharomyces cerevisiae. " J. Biol. Chem.. 1991 Mar 5; 266 (7) : 4417-24.
Pubmed PMID: 1999425.
Otero JH, Suo J, Gordon C, Chang EC. " Int6 and Moe1 interact with Cdc48 to regulate ERAD and proper chromosome segregation. " Cell Cycle. 2010 Jan 1; 9 (1) : 147-61.
Pubmed PMID: 20016281.
Suo J, Snider SJ, Mills GB, Creighton CJ, Chen AC, Schiff R, Lloyd RE, Chang EC. " Int6 regulates both proteasomal degradation and translation initiation and is critical for proper formation of acini by human mammary epithelium. " Oncogene. 2011 Feb 10; 30 (6) : 724-36.
Pubmed PMID: 20890303.
Sha Z, Yen HC, Scheel H, Suo J, Hofmann K, Chang EC. " Isolation of the Schizosaccharomyces pombe proteasome subunit Rpn7 and a structure-function study of the proteasome-COP9-initiation factor domain. " J. Biol. Chem.. 2007 Nov 2; 282 (44) : 32414-23.
Pubmed PMID: 17761670.
Bandyopadhyay A, Lakshmanan V, Matsumoto T, Chang EC, Maitra U. " Moe1 and spInt6, the fission yeast homologues of mammalian translation initiation factor 3 subunits p66 (eIF3d) and p48 (eIF3e), respectively, are required for stable association of eIF3 subunits. " J. Biol. Chem.. 2002 Jan 18; 277 (3) : 2360-7.
Pubmed PMID: 11705997.
Chen CR, Li YC, Chen J, Hou MC, Papadaki P, Chang EC. " Moe1, a conserved protein in Schizosaccharomyces pombe, interacts with a Ras effector, Scd1, to affect proper spindle formation. " Proc. Natl. Acad. Sci. U.S.A.. 1999 Jan 19; 96 (2) : 517-22.
Pubmed PMID: 9892665.
Cabrera R, Sha Z, Vadakkan TJ, Otero J, Kriegenburg F, Hartmann-Petersen R, Dickinson ME, Chang EC. " Proteasome nuclear import mediated by arc3 can influence efficient DNA damage repair and mitosis in schizosaccharomyces pombe. " Mol. Biol. Cell. 2010 Sep ; 21 (18) : 3125-36.
Pubmed PMID: 20668161.
Yen HC, Espiritu C, Chang EC. " Rpn5 is a conserved proteasome subunit and required for proper proteasome localization and assembly. " J. Biol. Chem.. 2003 Aug 15; 278 (33) : 30669-76.
Pubmed PMID: 12783882.
Cabrera R, Suo J, Young E, Chang EC. " Schizosaccharomyces pombe Arc3 is a conserved subunit of the Arp2/3 complex required for polarity, actin organization, and endocytosis. " Yeast. 2011 Jun ; 28 (6) : 495-503.
Pubmed PMID: 21449051.
Yen HC, Gordon C, Chang EC. " Schizosaccharomyces pombe Int6 and Ras homologs regulate cell division and mitotic fidelity via the proteasome. " Cell. 2003 Jan 24; 112 (2) : 207-17.
Pubmed PMID: 12553909.
Li Y, Chang EC. " Schizosaccharomyces pombe Ras1 effector, Scd1, interacts with Klp5 and Klp6 kinesins to mediate cytokinesis. " Genetics. 2003 Oct ; 165 (2) : 477-88.
Pubmed PMID: 14573463.
Sha Z, Brill LM, Cabrera R, Kleifeld O, Scheliga JS, Glickman MH, Chang EC, Wolf DA. " The eIF3 interactome reveals the translasome, a supercomplex linking protein synthesis and degradation machineries. " Mol. Cell. 2009 Oct 9; 36 (1) : 141-52.
Pubmed PMID: 19818717.
Papadaki P, Pizon V, Onken B, Chang EC. " Two ras pathways in fission yeast are differentially regulated by two ras guanine nucleotide exchange factors. " Mol. Cell. Biol.. 2002 Jul ; 22 (13) : 4598-606.
Pubmed PMID: 12052869.
Yen HC, Chang EC. " Yin6, a fission yeast Int6 homolog, complexes with Moe1 and plays a role in chromosome segregation. " Proc. Natl. Acad. Sci. U.S.A.. 2000 Dec 19; 97 (26) : 14370-5.
Pubmed PMID: 11121040.
Zheng, Z. Y. Tian, L. Bu, W. Fan, C. Gao, X. Wang, H. Liao, Y. H. Li, Y. Lewis, M. T. Edwards, D. Zwaka, T. P. Hilsenbeck, S. G. Medina, D. Perou, C. M. Creighton, C. J. Zhang, X. H. Chang, E. C.. " Wild-Type N-Ras, Overexpressed in Basal-like Breast Cancer, Promotes Tumor Formation by Inducing IL-8 Secretion via JAK2 Activation " Cell Reports. 2018 ; 12 : 511-524.
Pubmed PMID: 26166574.
Zheng ZY, Anurag M, Lei JT, Cao J, Si ... Chen Y, Lavere P, Li J, Du XH, Cakar B, Song W, Kim BJ, Shi J, Seker S, Chan DW, Zhao GQ, Chen X, Banks KC, Lanman RB, Shafaee MN, Zhang XH, Vasaikar S, Zhang B, Hilsenbeck SG, Li W, Foulds CE, Ellis MJ, Chang EC. " Neurofibromin Is an Estrogen Receptor-alpha Transcriptional Co-repressor in Breast Cancer " Cancer Cell. 2020 ; 37 : 387-402.
Pubmed PMID: 32142667.
Zheng Z-Y, Chen A, Jaehnig EJ, Anurag M, Lei JT, Feng L, Wang C, Fandino D, Singh P, Kennedy H, Yadav G, Vollert CT, Tsai J, Chen X, Li Y, Lim B, Thompson A, Li S, Foulds CE, Zhang B, Ellis MJ, Chang EC:. " NF1-depleted ER+ breast cancers are differentially sensitive to CDK4/6 inhibitors.. " Sci. Transl. Med.. 2025 Aug 27; 17 : eadq5492.

Languages

Chinese (Mandarin)