Xiang Zhang, Ph.D
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Xiang Zhang, Ph.D
Interim Director
Positions
- Interim Director
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Lester and Sue Smith Breast Center
- William T. Butler, M.D., Endowed Chair for Distinguished Faculty
-
Baylor College of Medicine
- Professor
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Molecular and Cellular Biology
Baylor College of Medicine
Houston, TX US
- McNair Scholar
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Baylor College of Medicine
Houston, Texas United States
- Member
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Dan L. Duncan Comprehensive Cancer Center
Education
- Post-Doctoral Fellowship at Memorial Sloan Kettering Cancer Center
- 06/2011 - New York, New York United States
- PhD from Columbia University
- 05/2006 - New York, New York United States
- BS from Fu-Dan University
- 01/2000 - Shanghai, China, People's Rep
Honors & Awards
- Era of Hope Scholar
- Department of Defense Congressionally Directed Medical Research Programs, Breast Cancer Research Program (03/2016 - 03/2021)
- NIH Pathway to Independence Award (K99/R00)
- National Cancer Institute (09/2010 - 09/2014)
- Career Catalyst Research Award
- Susan G. Komen Foundation (09/2014 - 08/2017)
- Excellence in Research
- Department of Molecular and Cellular Biology, BCM (08/2016)
- Michael E. DeBakey Award for Excellence in Research
- Baylor College of Medicine (05/2018)
- Sue Eccles Young Investigator Award
- Metastasis Research Society (08/2018)
- Laura Zisken Prize
- Stand Up To Cancer (01/2020 - 01/2021)
- Leadership Award
- Theresa's Research Foundation (10/2016)
Websites
Selected Publications
- Xiang H.-F. Zhang*, X Jin*, S Malladi, YH Wen, E Brogi, M Smid, JA Foekens, and J Massagué. "Bone Metastasis seed pre-selection by the primary tumour stroma." Cell. 2013;154(5):1060-73. Pubmed PMID: 3974915
- H Wang; C Yu; X Gao; T Welte; A Muscarella; L Tian; J Liu; H Zhao; Z Zhao; J Tao; B Lee; TF Westbrook; STC Wong; JM. Rosen; CK Osborne; Xiang H.-F. Zhang "The Osteogenic Niche Promotes Early-Stage Bone Colonization of Disseminated Breast Cancer Cells." Cancer Cell. 2015 Feb 9;27(2):193-210.
- T Welte, IS Kim, L Tian, X Gao, H Wang, J Li, XB Holdman, JI Herschkowitz, A Pond, G Xia, S Kurley, T Nguyen, L Liao, LE Dobrolecki, Q Mo, DP Edwards, S Huang, L Xin, J Xu, Y Li, MT Lewis, T Wang, TF Westbrook, JM Rosen*, and Xiang H.-F. Zhang* "Oncogenic mTOR signaling recruits myeloid-derived suppressor cells to promote tumor initiation.." Nature Cell Biology. 2016 Jun;18:632-644.
- L Tian, A Goldstein, H Wang, IS Kim, HC Lo, T Welte, K Sheng, L Dobrolecki, X Zhang, N Putluri, T Phung, SA Mani, F Stossi, A Sreekumar, MA Mancini, C Zong, WK Decker, MT Lewis, and Xiang H.-F. Zhang "Mutual regulation of tumour vessel normalization and immunostimulatory reprogramming." Nature. 2017 Apr 3;544(7649):250-254.
- H Wang, L Tian, A Goldstein, HC Lo, J Liu, K Sheng, G Zbigniew, F Stossi, C Zong, Z Li, MA Mancini and Xiang H.-F. Zhang "Bone-in-culture array as a platform to model early-stage bone metastases and discover anti-metastasis therapies." Nature Communications. 2017;8(15045):DOI: 10.1038/ncomms15045.
- H Wang, L Tian, J Liu, A Goldstein, I Bado, W Zhang, BR Arenkiel, Z Li, M Yang, S Du, H Zhao, DR Rowley, STC Wong, Z Gugala, and Xiang H.-F. Zhang "The osteogenic niche is a calcium reservoir of bone micrometastases and confers unexpected therapeutic vulnerability." Cancer Cell. ;34(5):823-839.
- Kim IS, Gao Y, Welte T, Wang H, Liu J, Janghorban M, Sheng K, Niu Y, Goldstein A, Zhao N, Bado I, Lo H-C, ..., Li Y, Mo Q, Westbrook TF, Zong C, Rao A, Sreekumar A, Rosen JM, Zhang XHF "Immuno-subtyping of breast cancer reveals distinct myeloid cell profiles and immunotherapy resistance mechanisms." Nature Cell Biology. 2019 Sep;21(9):1113-1126.
- Lo HC, Xu Z, Kim IS, Pingel B, Aguirre S, Kodali S, Liu J, Zhang W, Muscarella AM, Hein SM, Krupnick AS, Neilsen JR, Paust S, Rosen JM, Wang H, and Xiang H.-F. Zhang "Resistance to Natural Killer cell immunosurveillance confers a selective advantage to polyclonal metastasis." Nature Cancer. 2020;1:709–722.
- Muscarella MM, Dai W, Mitchell PG, Zhang W, Wang H, Jia L, Stossi F, Mancini MA, Chiu W, and Xiang H.-F. Zhang "Unique cellular protrusions mediate breast cancer cell migration by tethering to osteogenic cells." NPG Breast Cancer. 2020 Sep 7
- Zhang W*, Bado IL*, Hu J, Wan YW, Wu L, Wang H, Gao Y, Jeong HH, Xu Z, Hao X, Lege BM, AI-Ouran R, Li L, Li J, Yu L, Singh S, Lo H-C, Niu M, Liu J, Jiang W, Li Y, Wong STC, Cheng C, Liu Z, Xiang H.-F. Zhang "The bone microenvironment invigorates metastatic seeds for further dissemination." Cell. 2021 Apr 19;Online ahead of print(*: Equal contribution)
- Bado IL*, Zhang W*, Wang H, Hu J, Sarkar P, Liu J, Zbigniew G, Xu Z, Zhang W, Li L, Wan YW, Wu W, Lo H-C, Kim IS, Singh S, Janghorban M, Muscarella A, Goldstein A, Singh P, Jeong HH, Liu C, Huang S, Schiff R, Gaber MW, Liu Z, Ellis MJ, Xiang H.-F. Zhang "The bone microenvironment increases phenotypic plasticity of ER+ breast cancer." Dev. Cell. 2021 Apr 19;56(8):1100-1117 *: equal contribution.
- Zeru Tian, Ling Wu, Chenfei Yu, Yuda Chen, Zhan Xu , Igor Bado , Axel Loredo , Lushun Wang , Hai Wang , Kuan-Lin Wu , Weijie Zhang , Xiang H.-F. Zhang*, Han Xiao* "Harnessing the power of antibodies to fight bone metastasis." Sci. Adv. 2021 Jun 23;7(eabf2051):* Co-senior authors.
Memberships
- American Association of Cancer Research
- Member (01/2012)
- Metastasis Research Society
- Member (03/2016)
- American Association of Immunology
- Member (12/2016)
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