Email

sjhan@bcm.edu

Positions

Associate Professor

Mol & Cell Biology-Mol.Regulation
Dan L. Duncan Cancer Center and Center for Reproductive Medicine
Baylor College of Medicine
Houston, TX US

Member

Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas United States

Addresses

BCM-Michael DeBakey Center (Office)

Room: BCMM-M711A
Houston, TX 77030
United States

Lab (Lab)

BCM-Micheal DeBakey Center
Room: BCMM-M711
Houston, TX 77030
United States

Education

Post-Doctoral Fellowship at Samsung Biomedical Reserach Institute

03/1997 - Seoul, South Korea

PhD from Seoul National University

02/1997 - Seoul, South Korea

Post-Doctoral Fellowship at Baylor College Of Medicine

06/2000 - Houston, Texas United States

Certifications

Medical Degree

BCM

Professional Interests

• Pathogenic Role of Steroid Receptor Coactivator and Nuclear Receptor in Women's Reproductive Disease

Professional Statement

As an estrogen-dependent pro-inflammatory disease, endometriosis is defined as the colonization and growth of endometrial tissues at anatomic sites outside of the uterine cavity, primarily on the pelvic peritoneum and ovaries. Up to 5-10% of reproductive-aged women worldwide chronically suffer from endometriosis symptoms, such as pelvic pain and infertile. Due to the severe chronic morbidity associated with this gynecological disorder, our study has attempted to identify the distinguishing molecular features of endometriotic lesions and endometrial dysfunction to develop more effective prognostic, diagnostic, and/or treatment strategies for the clinical management of this debilitating disease and the amelioration of endometriosis-associated infertility.

Project 1: Estrogen/Estrogen Receptor Beta axis in endometriosis.
Endometriosis is an estrogen-dependent disease. Therefore, the estrogen/Estrogen Receptor (ER)s axis has a critical role in endometriosis progression. Among ERs, the ER-beta level is significantly elevated in endometriotic tissues as compared with normal endometriosis. Now, we will investigate the role of ER-beta in endometriosis progression with the OMICs data set.

Project 2: Dysregulation of Immune in endometriosis
Retrograde menstruation is the main driving factor to initiate the endometriosis progression. To shedding endometrial fragments is developed into endometriotic lesions, the immune system should be dysregulated compared to normal women. However, it is not elucidated how the immune system is changed in endometriosis patients to allow endometriotic lesions. Now, we investigate how endometriotic lesions dysregulate and then generate an endometriosis-competent immune environment to enhance endometriosis.

Project 3: Endocrine disruptor in endometriosis progression
The central hypothesis of endometriosis is retrograde menstruation. Most of the reproductive-aged women (90%) have experienced retrograde menstruation, but 10% of women suffer from endometriosis symptoms. In addition to retrograde menstruation, however, other factors should involve in the initiation of endometriosis. Our hypothesis is the exposure of the environment hormone causes endometriosis progression along with retrograde menstruation. Now, we will investigate the molecular etiology of environmental hormone in endometriosis initiation.

Project 4: Alteration of epigenetic regulation in endometriosis
In addition to genetic variation, the altered epigenomic pattern is also associated with the endometriosis progression. For example, the DNA methylation pattern is quite different between normal endometrium versus endometriotic tissues. Therefore, our project aims to define how DNA methyltransferase involves endometriosis progression with various animal models and human endometriotic lesions.

Project 5: Genetic Mutation Causing Endometriosis
Previous studies revealed exon specific gene mutations are defined in endometriosis patients. However, it is not clearly elucidated whether these genes mutation causes endometriosis progression. Using the CRISPR/Cas9 system, we will determine whether these gene mutations initiate and progress the endometriosis.

Project 6: Diet therapy for the endometriosis
Our studies revealed that ER-beta has an essential role in endometriosis progression. However, most ER-beta antagonists also inhibit ER-alpha activity in vivo and cause side effects by suppressing ER-alpha activity. To effectively suppress endometriosis without side effects, we have screened natural ligands that effectively inhibit ER-beta activity but not ER-alpha activity. Now, we will investigate whether foods that contain high levels of ER-beta inhibiting natural ligands suppress the endometriosis progression.

Websites

Videos

Selected Publications

• Han SJ, O'Malley BW. "The dynamics of nuclear receptors and nuclear receptor coregulators in the pathogenesis of endometriosis." Hum Reprod Update. 2014 Mar 14; Pubmed PMID: 24634322
• Han SJ, O'Malley BW, DeMayo FJ "An estrogen receptor alpha activity indicator model in mice.." Genesis. 2009 Dec;47(12):815-24. Pubmed PMID: 19882671
• Han SJ, Lonard DM, O'Malley BW "Multi-modulation of nuclear receptor coactivators through posttranslational modifications.." Trends Endocrinol. Metab.. 2009 Jan;20(1):41501. Pubmed PMID: 19019695
• Han SJ, Jung SY, Malovannaya A, Kim T, Lanz RB, Qin J, O'Malley BW "A scoring system for the follow up study of nuclear receptor coactivator complexes.." Nucl Recept Signal. 2006;4:e014. Pubmed PMID: 16862220

Funding

The Genomic Function of Estrogen Receptor Beta in Endometriosis - #R01 HD098059-01A1

$1,925,830.00 (03/06/2020 - 12/31/2024)

Grant funding from NICHD

The major goals of this project are to define how the specific ER-beta mediated gene network modulate antiapoptosis, epithelial-mesenchymal transition and angiogenesis of endometriotic lesions for the progression of endometriosis.