Margaret A. Goodell, Ph.D.
Professor and Chair
Positions
- Professor and Chair
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Molecular and Cellular Biology
Baylor College of Medicine
Houston, Texas, United States
- Vivian L. Smith Chair in Regenerative Medicine
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Baylor College of Medicine
Houston, Texas, United States
- Director
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Stem Cells and Regenerative Medicine Center (STaR)
Baylor College of Medicine
Houston, Texas, United States
- Member
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Center for Cell and Gene Therapy (CAGT)
Baylor College of Medicine
Houston, Texas, United States
- Co-Leader, Cancer Cell and Gene Therapy
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Dan L. Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas, United States
Addresses
- Baylor College of Medicine (Office)
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1 Baylor Plaza
BCM130
Houston, TX, 77030
United States
Phone: (713) 798-6037
- Baylor College of Medicine (Office)
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Assistant: Pon Vongsombath
Houston, TX, 77030
United States
Phone: (713) 798-6037
pon.vongsombath@bcm.edu
Education
- BS from Imperial College, United Kingdom
- 01/1986 - London, United Kingdom
- PhD from University of Cambridge
- 01/1991 - Cambridge, United Kingdom
- Postdoctoral Fellowship at Whitehead Institute, M.I.T.
- 01/1996 - Cambridge, Massachusetts, United States
- Postdoctoral Fellowship at Harvard Medical School
- 01/1997 - Boston, Massachusetts, United States
Professional Interests
- Murine and human hematopoietic stem cells
- Genetic and epigenetic regulation and development
Professional Statement
Murine and human hematopoietic stem cells; genetic and epigenetic regulation and development.
We are interested in the basic biology of hematopoietic stem cells. It has been known for decades that hematopoietic stem cells reside in the bone marrow in a quiescent state and replenish the supply of differentiated cells of the peripheral blood throughout the lifetime of an animal. No other adult cell type retains the capacity for such immense proliferation and differentiation. However, little is known about the cells or factors that regulate their primitive state or control their activation. We study the behavior of these stem cells in vivo and in vitro using mouse stem cells as a model, as well as pursue the mechanisms which control their behavior on a molecular level using genome-wide profiling strategies and mouse mutants.
We are interested in the basic biology of hematopoietic stem cells. It has been known for decades that hematopoietic stem cells reside in the bone marrow in a quiescent state and replenish the supply of differentiated cells of the peripheral blood throughout the lifetime of an animal. No other adult cell type retains the capacity for such immense proliferation and differentiation. However, little is known about the cells or factors that regulate their primitive state or control their activation. We study the behavior of these stem cells in vivo and in vitro using mouse stem cells as a model, as well as pursue the mechanisms which control their behavior on a molecular level using genome-wide profiling strategies and mouse mutants.
Selected Publications
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Tovy A,Rosas C,Gaikwad AS,Medrano G,Zhang L,Reyes JM,Huang YH,Arakawa T,Kurtz, K,Conneely SE,Guzman AG,Aguilar R,Gao A,Chen CW,Kim JJ,Carter MT,Lasa-Aranzasti A,Valenzuela I,Van Maldergem L,Brunetti L,Hicks MJ,Marcogliese AN,Goodell MA and RE Rau. " Perturbed hematopoiesis in individuals with germline DNMT3A overgrowth Tatton-Brown-Rahman syndrome " Haematologica. 2021 Jun 3; Online ahead of print.
Pubmed PMID: 34092059. -
Huang YH,Chen CW,Sundaramurthy V,Słabicki M,Hao D,Watson CJ,Tovy A,Reyes JM,Dakhova O, Crovetti BR,Galonska C,Lee M,Brunetti L,Zhou Y,Tatton-Brown K,Huang Y,Cheng X,Meissner A, Valk PJ,Van Maldergem L,Sanders MA,Blundell JR,Li W,Ebert BL,MA Goodell. " Systematic profiling of DNMT3A variants reveals protein instability mediated by the DCAF8 E3 ubiquitin ligase adaptor " Cancer Discovery. 2021 Aug 24; Online ahead of print.
Pubmed PMID: 34429321. -
Zhang, X, Jeong, M, Huang, X, Wang, XQ, Wang, X, Zhou, W, Shamim, MS, Gore, H, Himadewi, P, Liu, Y, Bochkov, ID, Reyes, J, Doty, M, Huang, YH, Jung, H, Heikamp, E, Presser Aiden, A, Li, W, Su, J, Lieberman Aiden, E and MA Goodell. " Large DNA Methylation Nadirs Anchor Chromatin Loops Maintaining Hematopoietic Stem Cell Identity " Molecular Cell. 2020 May 7; 78 (3) : 506-521.
Pubmed PMID: 32386543. -
Hsu, JI, Dayaram, T, Tovy, A, De Braekeleer, ED, Jeong, M, Wang, F, Zhang, J, Garcia-Manero, G, Kantarjian, H, Vassiliou, G, Futreal, PA, Donehower, LA, Takahashi, K and MA Goodell. " PPM1D Mutations Drive Clonal Hematopoiesis in Response to Cytotoxic Chemotherapy " Cell Stem Cell. 2018 Nov 1; 23 (5) : 700-713.
Pubmed PMID: 30388424.
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