Sean Eric McGuire, M.D., Ph.D.

Associate Professor

(713) 798-9174

Email

sean.mcguire@bcm.edu

Positions

Associate Professor: Mol & Cell Biology-McGuire
Baylor College of Medicine
Houston, TX, US

Member: Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas, United States

Addresses

BCM-Michael DeBakey Center (Lab): Room: BCMM-M822
Houston, TX, 77030
United States
Phone: (713) 798-9174
Sean.McGuire@bcm.edu

Education

Residency at MD Anderson Cancer Center: 01/2009 - Houston, TX, United States; Radiation Oncology

M.D. from Baylor College Of Medicine: 01/2004 - Houston, TX, United States

PhD from Baylor College Of Medicine: 01/2003 - Houston, Texas, United States; Molecular & Cellular Biology

BA from Harvard: 06/1994 - Cambridge, Massachusetts, United States; Biochemistry and Molecular Biology

Professional Interests

Cancer cell metabolism; metabolic imaging

Websites

VIICTR Publications List

Selected Publications

McGuire SE. " DNA Damage and Repair Pathway Profiles as Biomarkers in High-Risk Prostate Cancer. " JAMA Oncol. 2016 Jan 7; 1-2.
Pubmed PMID: 26747678.
Hartig SM1, Hamilton MP2, Bader DA2, McGuire SE3.. " The miRNA Interactome in Metabolic Homeostasis. " Trends Endocrinol Metab.. 2015 Dec ; 26 (12) : 733-45.
Pubmed PMID: 26492831.
Hartig SM1, Bader DA1, Abadie KV1, Motamed M1, Hamilton MP1, Long W1, York B1, Mueller M1, Wagner M1, Trauner M1, Chan L1, Bajaj M1, Moore DD1, Mancini MA1, McGuire SE1.. " Ubc9 Impairs Activation of the Brown Fat Energy Metabolism Program in Human White Adipocytes. " Mol Endocrinol.. 2015 Sep ; 29 (9) : 1320-33.
Pubmed PMID: 26192107.
Chaluvally-Raghavan P, Zhang F, Pradeep S, Hamilton MP, Zhao X, Rupaimoole R, Moss T, Lu Y, Yu S, Pecot CV, Aure MR, Peuget S, Rodriguez-Aguayo C,…McGuire SE, Flores ER, Sood AK, Mills GB.. " Copy number gain of hsa-miR-569 at 3q26.2 leads to loss of TP53INP1 and aggressiveness of epithelial cancers. " Cancer Cell. 2014 Dec 8; 26 (6) : 863-79.
Pubmed PMID: 25490449.
Wang J1, Kudchadker R1, Choi S1, Pettaway CA2, Choi H3, Hobbs BD1, Occena MC1, McGuire SE1, Pugh TJ1, Hoffman K1, Mahmood U1, Kuban DA4.. " Local recurrence map to guide target volume delineation after radical prostatectomy. " Pract Radiat Oncol.. 2014 Nov ; 4 (6) : e239-46.
Pubmed PMID: 25407875.
Hoadley KA, Yau C, Wolf DM, Cherniack AD, Tamborero D, Ng S, Leiserson MD, Niu B, McLellan MD, Uzunangelov V, Zhang J, Kandoth C, Akbani R, Shen H, Omberg L, Chu A, Margolin AA, …. " Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin. " Cell.. 2014 Aug 14; 158 (4) : 929-44.
Pubmed PMID: 25109877.
Chapin BF1, McGuire SE2, Aparicio A2.. " Is treatment of the primary tumor in metastatic prostate cancer justified? " Eur Urol.. 2014 Jun ; 65 (6) : 1067-8.
Pubmed PMID: 24411278.
Bian SX1, Kuban DA, Levy LB, Oh J, Choi S, McGuire SE, Frank SJ, Mahmood U, Nguyen PL, Pugh TJ, Lee AK, Hoffman KE.. " The Influence of Age and Comorbidity on the Benefit of Adding Androgen Deprivation to Dose-escalated Radiation in Men With Intermediate-risk Prostate Cancer. " Am J Clin Oncol.. 2014 Apr 11;
Pubmed PMID: 24732810.
Cerne JZ1, Hartig SM, Hamilton MP, Chew SA, Mitsiades N, Poulaki V, McGuire SE.. " Protein kinase C inhibitors sensitize GNAQ mutant uveal melanoma cells to ionizing radiation. " Send to: Invest Ophthalmol Vis Sci.. 2014 Apr 7; 55 (4) : 2130-9.
Pubmed PMID: 24595385.
Hoffman KE1, Voong KR2, Pugh TJ2, Skinner H2, Levy LB2, Takiar V2, Choi S2, Du W2, Frank SJ2, Johnson J2, Kanke J2, Kudchadker RJ2, Lee AK2, Mahmood U2, McGuire SE2, Kuban DA2.. " Risk of late toxicity in men receiving dose-escalated hypofractionated intensity modulated prostate radiation therapy: results from a randomized trial. " Int J Radiat Oncol Biol Phys.. 2014 Apr 1; 88 (5) : 1074-84.
Pubmed PMID: 24661661.
Coarfa C, Pichot C, Jackson A, Tandon A, Amin V, Raghuraman S, Paithankar S, Lee AV, McGuire SE, Milosavljevic A.. " Analysis of interactions between the epigenome and structural mutability of the genome using Genboree Workbench tools. " BMC Bioinformatics.. 2014 ; 15
Pubmed PMID: 25080362.
Pugh TJ1, Munsell MF, Choi S, Nguyen QN, Mathai B, Zhu XR, Sahoo N, Gillin M, Johnson JL, Amos RA, Dong L, Mahmood U, Kuban DA, Frank SJ, Hoffman KE, McGuire SE, Lee AK.. " Quality of life and toxicity from passively scattered and spot-scanning proton beam therapy for localized prostate cancer. " Int J Radiat Oncol Biol Phys.. 2013 Dec 1; 87 (5) : 946-53.
Pubmed PMID: 24139077.
Cerne JZ1, McGuire SE, Grant SR, Munsell MF, Lee AK, Kudchadker RJ, Choi SL, Mahmood U, Hoffman KE, Pugh TJ, Frank SJ, Kuban DA.. " Factors associated with improved biochemical response to neoadjuvant androgen deprivation therapy before definitive radiation therapy in prostate cancer patients. " Prostate Cancer Prostatic Dis.. 2013 Dec ; 16 (4) : 346-51.
Pubmed PMID: 23939133.
Pair ML1, Du W, Rojas HD, Kanke JE, McGuire SE, Lee AK, Kuban DA, Kudchadker RJ.. " Dosimetric effects of weight loss or gain during volumetric modulated arc therapy and intensity-modulated radiation therapy for prostate cancer. " Med Dosim.. 2013 ; 38 (3) : 251-4.
Pubmed PMID: 23540491.
Cancer Genome Atlas Research Network, Weinstein JN, Collisson EA, Mills GB, Shaw KR, Ozenberger BA, Ellrott K, Shmulevich I, Sander C, Stuart JM.. " The Cancer Genome Atlas Pan-Cancer analysis project. " Nat Genet.. 2013 Oct ; 45 (10) : 1113-20.
Pubmed PMID: 24071849.
Hartig SM1, Feng Q, Ochsner SA, Xiao R, McKenna NJ, McGuire SE, He B.. " Androgen receptor agonism promotes an osteogenic gene program in preadipocytes. " Biochem Biophys Res Commun.. 2013 May 3; 434 (2) : 357-62.
Pubmed PMID: 23567971.
Pugh TJ1, Frank SJ, Achim M, Kuban DA, Lee AK, Hoffman KE, McGuire SE, Swanson DA, Kudchadker R, Davis JW.. " Endorectal magnetic resonance imaging for predicting pathologic T3 disease in Gleason score 7 prostate cancer: implications for prostate brachytherapy. " Brachytherapy.. 2013 May ; 12 (3) : 204-9.
Pubmed PMID: 22673704.
Castle KO1, Hoffman KE, Levy LB, Lee AK, Choi S, Nguyen QN, Frank SJ, Pugh TJ, McGuire SE, Kuban DA.. " Is androgen deprivation therapy necessary in all intermediate-risk prostate cancer patients treated in the dose escalation era? " Int J Radiat Oncol Biol Phys.. 2013 Mar 1; 85 (3) : 693-9.
Pubmed PMID: 22836052.
McGuire SE1, Lee AK, Cerne JZ, Munsell MF, Levy LB, Kudchadker RJ, Choi SL, Nguyen QN, Hoffman KE, Pugh TJ, Frank SJ, Corn PG, Logothetis CJ, Kuban DA.. " PSA response to neoadjuvant androgen deprivation therapy is a strong independent predictor of survival in high-risk prostate cancer in the dose-escalated radiation therapy era. " Int J Radiat Oncol Biol Phys.. 2013 Jan 1; 85 (1) : e39-46.
Pubmed PMID: 23102837.
Hamilton MP1, Rajapakshe K, Hartig SM, Reva B, McLellan MD, Kandoth C, Ding L, Zack TI, Gunaratne PH, Wheeler DA, Coarfa C, McGuire SE.. " Identification of a pan-cancer oncogenic microRNA superfamily anchored by a central core seed motif. " Nat Commun.. 2013 ; 4 (2730)
Pubmed PMID: 24220575.
Hartig SM1, He B, Newberg JY, Ochsner SA, Loose DS, Lanz RB, McKenna NJ, Buehrer BM, McGuire SE, Marcelli M, Mancini MA.. " Feed-forward inhibition of androgen receptor activity by glucocorticoid action in human adipocytes. " Chem Biol.. 2012 Sep 21; 19 (9) : 1126-41.
Pubmed PMID: 22999881.
Bian SX1, Kuban DA, Levy LB, Oh J, Castle KO, Pugh TJ, Choi S, McGuire SE, Nguyen QN, Frank SJ, Nguyen PL, Lee AK, Hoffman KE.. " Addition of short-term androgen deprivation therapy to dose-escalated radiation therapy improves failure-free survival for select men with intermediate-risk prostate cancer. " Ann Oncol.. 2012 Sep ; 23 (9) : 2346-52.
Pubmed PMID: 22357249.
Cerne JZ1, Zong L, Jelinek J, Hilsenbeck SG, Wang T, Oesterreich S, McGuire SE.. " BRCA1 promoter methylation status does not predict response to tamoxifen in sporadic breast cancer patients. " Breast Cancer Res Treat.. 2012 Aug ; 135 (1) : 135-43.
Pubmed PMID: 22706629.
Kim MM1, Hoffman KE, Levy LB, Frank SJ, Pugh TJ, Choi S, Nguyen QN, McGuire SE, Lee AK, Kuban DA.. " Prostate cancer-specific mortality after definitive radiation therapy: who dies of disease? " Eur J Cancer.. 2012 Jul ; 48 (11) : 1664-71.
Pubmed PMID: 22336663.
Sharp HJ1, Swanson DA2, Pugh TJ1, Zhang M1, Phan J1, Kudchadker R3, Bruno TL3, Kuban DA1, Lee AK1, Choi S1, Nguyen QN1, Hoffman KE1, McGuire SE1, Frank SJ4.. " Screening colonoscopy before prostate cancer treatment can detect colorectal cancers in asymptomatic patients and reduce the rate of complications after brachytherapy. " Pract Radiat Oncol.. 2012 Jul ; 2 (3) : e7-e13.
Pubmed PMID: 24674130.
Hartmaier RJ1, Richter AS, Gillihan RM, Sallit JZ, McGuire SE, Wang J, Lee AV, Osborne CK, O'Malley BW, Brown PH, Xu J, Skaar TC, Philips S, Rae JM, Azzouz F, Li L, Hayden J, Henry NL, Nguyen AT, Stearns V, Hayes DF, Flockhart DA, Oesterreich S.. " A SNP in steroid receptor coactivator-1 disrupts a GSK3β phosphorylation site and is associated with altered tamoxifen response in bone. " Mol Endocrinol.. 2012 Feb ; 26 (2) : 220-7.
Pubmed PMID: 22174377.
Kim MM1, Hoffman KE, Levy LB, Frank SJ, Pugh TJ, Choi S, Nguyen QN, McGuire SE, Lee AK, Kuban DA.. " Improvement in prostate cancer survival over time: a 20-year analysis. " Cancer J.. 2012 Jan ; 18 (1) : 1-8.
Pubmed PMID: 22290249.
Hartmaier RJ1, Tchatchou S, Richter AS, Wang J, McGuire SE, Skaar TC, Rae JM, Hemminki K, Sutter C, Ditsch N, Bugert P, Weber BH, Niederacher D, Arnold N, Varon-Mateeva R, Wappenschmidt B, Schmutzler RK, Meindl A, Bartram CR, Burwinkel B, Oesterreich S.. " Nuclear receptor coregulator SNP discovery and impact on breast cancer risk. " BMC Cancer.. 2009 Dec 14; 9 (438)
Pubmed PMID: 20003447.
McGuire SE1, McGuire AL.. " Don't throw the baby out with the bathwater: enabling a bottom-up approach in genome-wide association studies. " Genome Res.. 2008 Nov ; 18 (11) : 1683-5.
Pubmed PMID: 18974262.
McGuire SE1, Frank SJ, Eifel PJ.. " Treatment of recurrent vaginal melanoma with external beam radiation therapy and palladium-103 brachytherapy. " Brachytherapy.. 2008 Oct ; 7 (4) : 359-63.
Pubmed PMID: 18778972.
Zhang X1, Zhao KL, Guerrero TM, McGuire SE, Yaremko B, Komaki R, Cox JD, Hui Z, Li Y, Newhauser WD, Mohan R, Liao Z.. " Four-dimensional computed tomography-based treatment planning for intensity-modulated radiation therapy and proton therapy for distal esophageal cancer. " Int J Radiat Oncol Biol Phys.. 2008 Sep 1; 72 (1) : 278-87.
Pubmed PMID: 18722278.
Peintinger F1, Kuerer HM, McGuire SE, Bassett R, Pusztai L, Symmans WF.. " Residual specimen cellularity after neoadjuvant chemotherapy for breast cancer. " Br J Surg.. 2008 Apr ; 95 (4) : 433-7.
Pubmed PMID: 18161887.
Dawood S1, Broglio K, Kau SW, Islam R, Symmans WF, Buchholz TA, McGuire SE, Meric-Bernstam F, Cristofanilli M, Hortobágyi GN, Gonzalez-Angulo AM.. " Prognostic value of initial clinical disease stage after achieving pathological complete response. " Oncologist.. 2008 Jan ; 13 (1) : 6-15.
Pubmed PMID: 18245008.
McGuire AL1, Cho MK, McGuire SE, Caulfield T.. " Medicine. The future of personal genomics. " Science.. 2007 Sep 21; 317 (5845) : 1687.
Pubmed PMID: 17885116.
McGuire SE1, Gonzalez-Angulo AM, Huang EH, Tucker SL, Kau SW, Yu TK, Strom EA, Oh JL, Woodward WA, Tereffe W, Hunt KK, Kuerer HM, Sahin AA, Hortobagyi GN, Buchholz TA.. " Postmastectomy radiation improves the outcome of patients with locally advanced breast cancer who achieve a pathologic complete response to neoadjuvant chemotherapy. " Int J Radiat Oncol Biol Phys.. 2007 Jul 15; 68 (4) : 1004-9.
Pubmed PMID: 17418973.
Alkhatib AA1, McGuire SE.. " Photo quiz. Sine waves. " Neth J Med.. 2007 Apr ; 65 (4) : 153,155.
Pubmed PMID: 17452766.
Gonzalez-Angulo AM1, McGuire SE, Buchholz TA, Tucker SL, Kuerer HM, Rouzier R, Kau SW, Huang EH, Morandi P, Ocana A, Cristofanilli M, Valero V, Buzdar AU, Hortobagyi GN.. " Factors predictive of distant metastases in patients with breast cancer who have a pathologic complete response after neoadjuvant chemotherapy. " J Clin Oncol.. 2005 Oct 1; 23 (28) : 7098-104.
Pubmed PMID: 16192593.
McGuire SE1, Deshazer M, Davis RL.. " Thirty years of olfactory learning and memory research in Drosophila melanogaster. " Prog Neurobiol.. 2005 Aug ; 76 (5) : 328-47.
Pubmed PMID: 16266778.
McGuire SE1, Roman G, Davis RL.. " Gene expression systems in Drosophila: a synthesis of time and space. " Trends Genet.. 2004 Aug ; 20 (8) : 384-91.
Pubmed PMID: 15262411.
McGuire SE1, Mao Z, Davis RL.. " Spatiotemporal gene expression targeting with the TARGET and gene-switch systems in Drosophila. " Sci STKE.. 2004 Feb 12; 2004 (220) : pl6.
Pubmed PMID: 14970377.
McGuire SE1, Le PT, Osborn AJ, Matsumoto K, Davis RL.. " Spatiotemporal rescue of memory dysfunction in Drosophila. " Science.. 2003 Dec 5; 302 (5651) : 1765-8.
Pubmed PMID: 14657498.
McGuire SE1, Davis RL.. " Presenilin-1 and memories of the forebrain. " Neuron.. 2001 Dec 6; 32 (5) : 763-5.
Pubmed PMID: 11738022.
McGuire SE1, Le PT, Davis RL.. " The role of Drosophila mushroom body signaling in olfactory memory. " Science.. 2001 Aug 17; 293 (5533) : 1330-3.
Pubmed PMID: 11397912.
Lee AV1, Weng CN, McGuire SE, Wolf DM, Yee D.. " Lac repressor inducible gene expression in human breast cancer cells in vitro and in a xenograft tumor. " Biotechniques.. 1997 Dec ; 23 (6) : 1062-8.
Pubmed PMID: 9421637.
Yee D1, McGuire SE, Brünner N, Kozelsky TW, Allred DC, Chen SH, Woo SL.. " Adenovirus-mediated gene transfer of herpes simplex virus thymidine kinase in an ascites model of human breast cancer. " Hum Gene Ther.. 1996 Jun 20; 7 (10) : 1251-7.
Pubmed PMID: 8793549.
Lehming N1, McGuire S, Brickman JM, Ptashne M.. " Interactions of a Rel protein with its inhibitor. " Proc Natl Acad Sci U S A.. 1995 Oct 24; 92 (22) : 10242-6.
Pubmed PMID: 7479760.
McGuire SE1, Hilsenbeck SG, Figueroa JA, Jackson JG, Yee D.. " Detection of insulin-like growth factor binding proteins (IGFBPs) by ligand blotting in breast cancer tissues. " Cancer Lett.. 1994 Feb 28; 77 (1) : 25-32.
Pubmed PMID: 7512885.
McGuire SE1, Fuqua SA, Naylor SL, Helin-Davis DA, McGuire WL.. " Chromosomal assignments of human 27-kDa heat shock protein gene family. " Somat Cell Mol Genet.. 1989 Mar ; 15 (2) : 167-71.
Pubmed PMID: 2538929.