Research

Optical Imaging and Vital Microscopy Core

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About the Core

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The Optical Imaging and Vital Microscopy Core provides state-of-the-art instrumentation and cutting-edge imaging/image analysis tools for the research applications of a broad range of Baylor College of Medicine investigators. This core is dedicated to vital and intravital imaging of cellular processes within cells, intact tissue explants, developing embryos and functioning organs within the live animal. Our users are focused on a variety of applications such as understanding cell migration, optimizing angiogenic therapies, how blood flow influences development and cancer, immune cell recruitment, stem cell-niche interactions and cancer metastasis.

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Microscopy Methods

Description

The following microscopy methods are available through the Optical Imaging and Vital Microscopy Core. View information on each below:

Terms

Fluorescence Microscopy

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Learn more about the cornerstone of our imaging capabilities that can be used with a wide array of sample types.

LightSheet Microscopy

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Learn more about how this novel 3D imaging technology can provide more insight into cleared whole mounts.

Confocal Microscopy

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Learn more about how our confocal microscopes can improve your fluorescence images.

Multi-Photon Microscopy

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Learn more about how our 2-Photon microscopes can help you see deeper into intact tissue.

µCT (Micro Computed Tomography)

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Learn more about how μCT technology can generate 3D images from unlabeled samples.

OPT (Optical Projection Tomography)

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Learn more about how our custom built OPT solutions provide fast optical sectioning for biological specimens.

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Need Imaging Services?

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Visit our Services page to learn more about which service level is right for you.

Want to speak with OiVM Staff about your experiment? Fill out our User Request Form using the button below.

User Request Form
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Kevin Roarty and Hongjiang Si
The image this month is a human breast cancer organoid in a collagen-based 3D matrix. The cancer cells (magenta) lack the noncanonical Wnt receptor, Ror2. The protein fibronectin (orange) is up-regulated and assembled by Ror2-deficient tumor cells, triggering the invasion, dissemination and survival of cancer cells during metastatic transit. Nuclei are depicted in gray.
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From the Labs Image of the Month

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The image this month is a human breast cancer organoid in a collagen-based 3D matrix. The image was captured on the Zeiss LSM 880 with Airyscan FAST Confocal Microscope in the Optical Imaging and Vital Microscopy Core at Baylor.

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