About the Lab
Our research laboratory is interested in all aspects of epigenetics. We have particularly focused on transcriptional regulation by DNA methylation across development and tumorigenesis. We are using cutting-edge technologies, including single-cell transcriptomics, epigenomics and CRISPR-mediated epigenome editing, to delineate the functions of DNA methylation and to uncover new strategies for disease prevention and treatment.
Our research is organized around three key themes:
- Developmental Epigenetics: How does DNA methylation regulate embryonic development?
- Microbial Interactions: How does the gut microbiome affect host intestinal epigenetics?
- Cancer Epigenetics: What are the functional roles of cancer-associated DNA methylation? Can nutrition and diet impact causal epigenetic mechanisms?
Publications
Our research projects and studies result in publications in PubMed and other scientific journals.
USDA/ARS Children's Nutrition Research Center
The Shen Lab is part of the USDA/ARS Children's Nutrition Research Center which conducts basic and clinical research that represents the vibrant and diverse scope of childhood nutrition. Studies carried out at the CNRC investigate molecular mechanisms of metabolic diseases, human nutrition and metabolism, plant physiology, epidemiology, and community-based health. The CNRC houses laboratories supported by state-of-the-art equipment, room calorimeters, a greenhouse, a metabolic kitchen, multiple observation labs, as well as accommodations for research volunteers.
Lanlan Shen Lab
Texas Medical Center
Children's Nutrition Research Center
1100 Bates Ave., Houston, TX 77030
Email: lanlan.shen@bcm.edu / Phone: 713-798-0317