Baylor Remains Open

Baylor College of Medicine and its clinics will be open Monday, Nov. 28. We are closely monitoring the City of Houston's boil water advisory and will provide updates as needed.

Lanlan Shen Lab

Lanlan Shen Lab Publications


Shi J, Xu J, Chen Y, Li J, Shen L, Li JJ, Li W. The concurrence of DNA methylation and demethylation is associated with transcription regulation. Nature Communications. 2021 Sept 6; 12(1):5285. PMID: 34489442 PMCID: PMC8421433

Peery RC, Pammi M, Claud E, Shen L. Epigenome – A mediator for host-microbiome crosstalk. Semin Perinatol. 2021 Jun 17: 151455. Pubmed PMID: 34246487

Alves da Silva AV, de Castro Oliveira SB, Di Rienzi SC, Brown-Steinke K, Dehan LM, Rood JK, Carreira VS, Le H, Maier EA, Betz KJ, Aihara E, Ley RE, Preidis GA, Shen L, Moore SR. Murine methyl donor deficiency impairs early growth in association with dysmorphic small intestinal crypts and reduced gut microbial community diversity. Curr Dev Nutr., 2019 3 (1): nzy070. https://doi.org/10.1093/cdn/nzy070

Schraw JM, Yiu TT, Lupo PJ, Tsavachidis S, Rau R, Bondy ML, Rabin KR, Shen L, Scheurer ME. Maternal folate genes and aberrant DNA hypermethylation in pediatric acute lymphoblastic leukemia. PlosOne, 2018 13 (5): e0197408.  Pubmed PMID: 29763473 PMCID: PMC5953491

Parikh N, Shuck RL, Gagea M, Shen L, Donehower LA. Enhanced inflammation and attenuated tumor suppressor pathways are associated with oncogene-induced lung tumors in aged mice. Aging Cell. 2018 17 (1). 12691. Pubmed PMID: 29047229 PMCID: PMC5771401

Yu DH, Gadkari M, Zhou Q, Yu S, Gao N, Guan Y, Schady D, Roshan TN, Chen MH, Laritsky E, Ge Z, Wang H, Chen R, Westwater C, Bry L, Waterland RA, Moriarty C, Hwang C, Swennes AG, Moore SR, Shen L. Postnatal epigenetic regulation of intestinal stem cells requires DNA methylation and is guided by the microbiome. Genome Biol. 2015 Sep 30; 16:211. Pubmed PMID: 26420038 PMCID: PMC4589031

Sakamori R, Yu S, Zhang X, Hoffman A, Sun J, Das S, Vedula P, Li G, Fu J, Walker F, Yang CS, Yi Z, Hsu W, Yu DH, Shen L, Rodriguez AJ, Taketo MM, Bonder EM, Verzi MP, Gao N. CDC42 inhibition suppresses progression of incipient intestinal tumors. Cancer Res. 2014; 74(19): 5480. Pubmed PMID: 25113996 PMCID: PMC4184946

Yu DH, Waterland RA, Zhang P, Schady D, Chen MH, Guan Y, Gadkari M, Shen L. Targeted p16Ink4a epimutation causes tumorigenesis and reduces survival in mice. J Clin Invest. 2014; 124 (9): 3708. Pubmed PMID: 25061879 PMCID: PMC4151219

Yu DH, Ware C, Waterland RA, Zhang J, Chen MH, Gadhari M, Kunde-Ramamoorthy G, Nosavanh LM, Shen L. Developmentally programmed 3’ CpG island methylation confers tissue- and cell-type specific transcriptional activation. Mol Cell Biol. 2013; 33 (9): 1845-58. Pubmed PMID: 23459939 PMCID: PMC3624169

Stadler BM, Ivanovska I, Mehta K, Song S, Nelson A, Tan Y, Mathieu J, Darby GC, Blau CA, Ware C, Peters G, Miller DG, Shen L, Cleary M, Ruohola-Baker H. Characterization of microRNAs involved in embryonic stem cell states. Stem Cells Dev 2010; 19 (7): 935-50. Pubmed PMID: 20128659 PMCID: PMC3128320

Shen L, Kantarjian H, Guo Y, Lin E, Shan J, Huang X, Berry D, Ahmed S, Zhu W, Pierce S, Kondo Y, Oki Y, Jelinek J, Saba H, Estey E, Issa JP. DNA methylation predicts survival and response to therapy in patients with myelodysplastic syndromes. J Clin Oncol 2009; 28 (4): 605-13. Pubmed PMID: 20038729 PMCID: PMC2815995

Ware CB, Wang L, Mecham BH, Shen L, Nelson AM, Bar M, Lamba DA, Dauphin DS, Buckingham B, Askari B, Lim R, Tewari M, Gartler SM, Issa JP, Pavlidis P, Duan Z, Blau A. Histone deacetylases inhibition elicits an evolutionarily conserved self renewal program in embryonic stem cells. Cell Stem Cell 2009; 4 (4): 359-69. Pubmed PMID: 19341625 PMCID: PMC2719860