About the Lab

The Ludtke Lab focuses on CryoEM/CryoET and quantitative image processing, applying these techniques to a wide range of biological systems ranging from individual macromolecules to whole cells.

For the last 20 years Dr. Ludtke and his group have been developing the EMAN software suite for both high resolution single particle analysis as well as in-situ and in-vitro tomography. This software has been used on a large fraction of the structures in the EMDataBank, and with over 30,000 downloads is one of the most widely used in the field. In addition to developing new image processing methods such as deep learning applications and bispectral analysis, my group engages in a wide range of biological projects, from the high resolution structure and dynamics of individual molecules to the study of functioning macromolecular assemblies within the cell. Recently, cryoEM has experienced a renaissance, largely due to the development of revolutionary direct detector technology, making this field directly competitive with X-ray crystallography for high resolution structural analysis, and providing many unique capabilities, such as in-situ structural biology.

This is an exciting time for the cryoEM field, with many opportunities to substantially advance our fundamental understanding of biomolecular interactions.