About the Lab
Our research interests center on the biology apoptosis and DNA damage. We specialize in multifunctional molecular probes which employ energy transfer, DNA-machines, nano-oscillators, bio-molecular chimeras, luminous fullerene and nanotube labels, isothermal amplification, exosomes.
Our currently funded projects deal with non-canonical cell death, efferocytosis, exosomes, and mRNA-based markers of cellular stress and injury. The main clinical models we use include stroke and glioblastoma.
Areas of Research Interest
- Apoptosis and DNA damage
- FRET probes, molecular machines
The following a current project studies for the Didenko Lab:
- FRET probes for analysis of serpin-mediated apoptosis in focal brain ischemia
- Imaging mRNA turnover in P-bodies and its application to brain ischemia
- Express assay for specific fluorescence imaging of apoptosis via phosphatase-assisted topoligation