GPCR (320x240)
An illustration showing the exploring and reprogramming the mechanisms of signal transduction across biological membranes.

Our long-term goal is to understand how ligand/ membrane receptor/ downstream effector systems transmit specific signals across biological membranes and to exploit this knowledge to reengineer signaling pathways.

We address these objectives using a combination of computational and experimental approaches to model, design and reprogram ligand/ receptor/ effector interaction networks. Our long-term goal is to deconstruct the complex function and quantitatively describe the basic principles underlying these signaling networks.

We are affiliated with the Dan L Duncan Comprehensive Cancer Center, the Department of Pharmacology, the Verna and Marrs McLean Department of Biochemistry and Molecular Biology, and the program in Quantitative and Computational Biosciences.