GPCR (320x240)
An illustration showing the exploring and reprogramming the mechanisms of signal transduction across biological membranes.

Our long-term goal is to understand how ligand/ membrane receptor/ downstream effector systems transmit specific signals across biological membranes and to exploit this knowledge to reengineer signaling pathways.

We address these objectives using a combination of computational and experimental approaches to model, design and reprogram ligand/ receptor/ effector interaction networks. Our long-term goal is to deconstruct the complex function and quantitatively describe the basic principles underlying these signaling networks.

We are affiliated with the Dan L. Duncan Cancer Center, the Department of Pharmacology, the Verna and Marrs McLean Department of Biochemistry and Molecular Biology, and the Program in Structural & Computational Biology and Molecular Biophysics.