Ross Poché Lab

Master
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About the Lab

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One of my lab's long-term goals is to elucidate the transcriptional and epigenetic mechanisms regulating retinal progenitor cell proliferation and differentiation, leading to new therapeutic interventions to restore sight and treat cancers such as retinoblastoma. Toward that end, projects aimed at characterizing mouse mutants suffering from defects in retinogenesis are ongoing. One specific aspect of our research is to determine precisely how mitochondrial activity and other bioenergetic pathways interface with cell cycle progression during development. Additionally, we aim to identify new strategies to promote retinal regeneration in response to photoreceptor damage. Here, we are interested in determining whether the mouse retina retains latent regenerative potential akin to other vertebrates such as the zebrafish and whether we can genetically "awaken" that potential to restore sight.

Our second focus is on the generation and characterization of novel mouse models recapitulating human craniofacial and neurodevelopmental birth defects. Recently, we have uncovered a previously unknown transcription factor network that is responsible for development of the neural crest-derived craniofacial skeleton.

In the lab, we employ (and enjoy) a multi-disciplinary approach utilizing genetic loss- and gain-of-function experiments, molecular biology and live retinal confocal microscopy.

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Ross Poché lab
retina
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Transcriptional Regulation of Retinal Progenitor Cell Proliferation

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Our main research focus is to elucidate those transcriptional and epigenetic programs that are essential for balancing retinal progenitor cell proliferation and differentiation. 

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Ross Poché lab
live retina
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Live Retinal Imaging

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We have developed a robust live imaging method to monitor retinal progenitor cell interkinetic nuclear migration coincident with cell cycle kinetics.

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Ross Poché Lab
Cranio
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Mouse Models of Novel Human Neurocristopathies and Neurodevelopmental Disorders

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We have developed novel mouse models of newly discovered human syndromes impacting craniofacial and CNS development. 

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Ross Poché Lab
mito
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Coupling of Cell Cycle Kinetics and Mitochondrial Energetics

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We seek to better understand the precise requirements for mitochondrial activity in proliferating cells during development.

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Support our Research

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Donations are used to support our research efforts to better understand and treat retinal developmental and degenerative diseases.

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Ross Poché Lab
Eye Images
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Our Approach

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Our lab utilizes mouse developmental genetics and live, fluorescent microscopy.