About the Lab
The Gallo Lab is a highly interdisciplinary research group that aims to develop new treatments for brain cancers.
Our team consists of bioinformaticians, computational scientists, biochemists and molecular biologists.
We use single-cell genomics, bulk genomic technologies, clinical samples and patient-derived preclinical models to identify epigenomic vulnerabilities in brain cancer.
We focus on the epigenetic properties of brain tumor cells for several reasons. First, because epigenetics determines cell function. In this context, we are especially interested in finding ways to block the epigenetic programs that enable brain tumor cells to behave similarly to stem cells.
Second, epigenetics is a strong driver in brain tumors, especially in children. We think epigenetic programs complement the few mutations in genes in pediatric brain cancer to initiate tumor formation, therapy resistance and recurrence. By understanding how epigenetic and genetic mechanisms contribute to the malignant process, we hope to identify new treatment options for incurable brain tumors.