Xia Gao Lab

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About the Lab

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The main focus of the Gao lab is to determine how nutritional inputs influence the onset, development, and progression of diseases, as well as develop state-of-the-art nutritional interventions to advance disease prevention and treatment, particularly cancer and obesity. We employ a wide range of in vivo mouse models and in vitro models combined with untargeted and targeted metabolomics, molecular biology, biochemistry, immunology and metagenomics approaches to gain insights into the mechanisms by which the nutrition-host-microbiome trinity affects disease development and control.

Our frontier work in dietary interventions has pioneered the effects of dietary methionine restriction (Nature, 2019) in human circulating metabolism, and its efficacy in cancer control, alone or in combination with chemotherapy or radiotherapy in multiple mouse cancer models. In addition to continued research into the mechanisms of methionine restriction-mediated cancer inhibition, we are currently engaging in nutritional rationale of a broader range of nutrients in the development of cancer and metabolic diseases in pursuit of more effective dietary therapies for metabolic diseases.

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USDA/ARS Children's Nutrition Research Center

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USDA/ARS Children's Nutrition Research Center Holcombe View
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The Gao Lab is part of the Children's Nutrition Research Center which houses state-of-the-art laboratories, a vast array of equipment, a greenhouse, observation labs, research volunteer accommodations, a metabolic kitchen, and an elite group of scientists conducting groundbreaking research.

Visit the CNRC
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Gao Lab
USDA/ARS Children's Nutrition Research Center
1100 Bates Ave., Houston, TX 77030

Office: (713) 798-7066 | Email: xia.gao@bcm.edu