The goal of the Chin Lab is to understand the cellular and network mechanisms underlying cognitive impairments in Alzheimer’s disease and other neurological disorders, and to identify therapeutic entry points for the treatment of these devastating diseases.
We use a multidisciplinary approach that combines biochemistry, molecular biology, in vivo physiology, and behavioral paradigms to identify the cellular alterations that lead to memory deficits in mouse models of diseases like AD and epilepsy. This approach includes video-recorded EEG to characterize patterns of (aberrant) brain activity in individual mice and correlate activity with performance in behavioral paradigms that test different aspects of memory and cognition. We also use biochemical, molecular and imaging techniques to identify links between particular genes and cognitive dysfunction on a mouse-by-mouse basis.
Finally, we use interventional strategies such as pharmacological treatments or viral expression of genes of interest to determine whether we can improve or restore cognition and behavior. This integrated approach allows us to investigate the molecular basis of memory impairments in AD and other neurological disorders, as well as identify and test novel therapeutic entry points for the treatment of these devastating diseases.