Hsiao-Tuan Chao Lab

Master
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Chao Lab Members - 2019
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Jan and Dan Duncan Neurological Research Institute - 2019

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(Left to right) top row: Darrion Nguyen, Veronica He, Rose (Fairouz) Elsaeidi; bottom row: Aarushi Nayak, Hsiao-Tuan Chao (P.I.), Nathan Bliss

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About the Lab

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Neurodevelopmental disorders encompass a broad constellation of conditions including intellectual disability, epilepsy, autism, schizophrenia, and other neuropsychiatric conditions. One emerging theme in the field is that disrupted inhibitory neuronal development and function is found in association with many neurologic and psychiatric disorders. This would be consistent with the growing body of knowledge that inhibitory neurons are highly diverse and key for virtually all aspects of neurobiology from neural circuit development to modulating neuronal activity to information processing.

In the Chao Lab, we integrate cross-species approaches in humans to uncover the genetic etiologies of neurodevelopmental disorders, fruit flies to elucidate the molecular pathways, and mice to explore the cascade of events in the mammalian brain. A wide variety of approaches and techniques are employed in our laboratory including genetically engineered mouse and fruit fly models, structural and functional analyses with electrophysiology, confocal and super-resolution imaging, transcriptomics, molecular and cellular assays, and comprehensive behavioral profiling. Our goal is to determine the role of inhibitory dysfunction in the pathogenesis of neurodevelopmental disorders by deciphering how genetic alterations perturb inhibition in the brain, impact neural development, and lead to abnormal neurologic output.

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Clinical Study

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Natural history and molecular mechanisms of neurodevelopmental and neuropsychiatric disorders, including EBF3-related Hypotonia, Ataxia, and Delayed Development Syndrome (HADDS).

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Chao Lab Celebrating International Women's Day
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Chao Lab Celebrating International Women's Day

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(Left to right) Jacqui Bridgeman, Veronica He, Darrion Nguyen, Hsiao-Tuan Chao (P.I.), Melissa Ortiz

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2019 McNair Medical Institute Research Symposium
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2019 McNair Medical Institute Research Symposium

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Rose (Fairouz) Elsaeidi (left), Darrion Nguyen (right)

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Chao Lab 2018, Jan and Dan Duncan Neurological Research Institute
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Jan and Dan Duncan Neurological Research Institute - 2018

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(Left to right): Hudin Jackson, Nathan Bliss, Darrion Nguyen, Hsiao-Tuan Chao (P.I.)

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2019 NIH High-Risk High-Reward Symposium
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Awardees

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2018 NIH High-Risk High-Reward Early Independence Awardees

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Jan and Dan Duncan Neurological Research Institute
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Hsiao-Tuan Chao Lab

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Jan and Dan Duncan Neurological Research Institute
1250 Moursund St
Houston, TX 77030

hsiaotuan.chao@bcm.edu
bridgema@bcm.edu
Phone: (832) 824-8806