Hsiao-Tuan Chao Lab

Master
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NRI Chao Lab 2020
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Chao Lab 2020

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(left to right - via zoom) top row: Hsiao-Tuan Chao, Darrion Nguyen, Harim Delgado Seo (right); bottom row: Maimuna Sali Paul, Vanessa Iroegbulem, John Hayes

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About the Lab

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Neurodevelopmental disorders encompass a broad constellation of conditions including intellectual disability, epilepsy, autism, schizophrenia, and other neuropsychiatric conditions. One emerging theme in the field is that disrupted inhibitory neuronal development and function is found in association with many neurologic and psychiatric disorders. This would be consistent with the growing body of knowledge that inhibitory neurons are highly diverse and key for virtually all aspects of neurobiology from neural circuit development to modulating neuronal activity to information processing.

In the Chao Lab, we integrate cross-species approaches in humans to uncover the genetic etiologies of neurodevelopmental disorders, fruit flies to elucidate the molecular pathways, and mice to explore the cascade of events in the mammalian brain. A wide variety of approaches and techniques are employed in our laboratory including genetically engineered mouse and fruit fly models, structural and functional analyses with electrophysiology, confocal and super-resolution imaging, transcriptomics, molecular and cellular assays, and comprehensive behavioral profiling. Our goal is to determine the role of inhibitory dysfunction in the pathogenesis of neurodevelopmental disorders by deciphering how genetic alterations perturb inhibition in the brain, impact neural development, and lead to abnormal neurologic output.

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Clinical Study

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Natural history and molecular mechanisms of neurodevelopmental and neuropsychiatric disorders, including EBF3-related Hypotonia, Ataxia, and Delayed Development Syndrome (HADDS).

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Jan and Dan Duncan Neurological Research Institute
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Contact Us

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Jan and Dan Duncan Neurological Research Institute
1250 Moursund St
Houston, TX 77030

hsiaotuan.chao@bcm.edu
bridgema@bcm.edu
Phone: (832) 824-8806