All Core Equipment List

Core	Instrument	Description
Biofluids Repository Core	Cell Analyzer - Cytek Muse	Tabletop microcapillary cell analyzer (simple 3 parameter flow cytometer)
Biofluids Repository Core	Cell Counter - Sysmex Hematology Analyzer	Performs automated blood counts and cell analysis
Cytometry and Cell Sorting Core	Cell Sorter - BD Ariall (x2)	5 laser conventional flow cytometric cell sorter, capable of sorting individual cells for downstream research applications
Cytometry and Cell Sorting Core	Core	5 laser conventional flow cytometric cell sorter, capable of sorting individual cells for downstream research applications
Cytometry and Cell Sorting Core	Cell Sorter - BD FACSDiscover S8 (x2)	5 laser imaging and spectral flow cytometric cell sorters, capable of sorting individual cells for downstream research applications
Cytometry and Cell Sorting Core	Cell Sorter - Miltenyi AutoMACS Pro	A benchtop instrument for automated cell sorting based on magnetic labeling, capable of isolating target cells with high purity and speed.
Single Cell Genomics Core	Cell Sorter - Pala	Benchtop cell sorter
Cytometry and Cell Sorting Core	Cell Sorter - Sony MA900	Benchtop cell sorter that features 4 lasers (405, 488, 561, 638 nm) and can detect up to 14 fluorescence channels.
Human Stem Cell and Neuronal Differentiation Core	Cell Sorter - Wolf	Gentle, microfluidics-based cell sorter that uses a disposable cartridge and can sort at rates of up to 30,000 cells per second.
Cytometry and Cell Sorting Core	Cell Viability Analyzer - Beckman Coulter Vi-Cell	Automated cell viability analyzer that uses trypan blue dye exclusion to count and determine viability for a quick analysis of a cell population.
Cytometry and Cell Sorting Core	Flow Cytometer - BD LSRII	High-end conventional flow cytometer, configured with 5 lasers and 18 fluorescence detectors for complex multi-color analysis.
Cytometry and Cell Sorting Core	Flow Cytometer - BD LSR Fortessa (x2)	Conventional flow cytometer configured with 5 lasers and up to 18 colors for deep phenotypic analysis.
Biofluids Repository Core	Flow Cytometer - BD LSR Fortessa	Conventional flow cytometer configured with 5 lasers and up to 18 colors for deep phenotypic analysis.
Cytometry and Cell Sorting Core	Flow Cytometer - BD LSRII	High-end conventional flow cytometer, configured with 4 lasers and 18 fluorescence detectors for complex multi-color analysis.
Cytometry and Cell Sorting Core	Flow Cytometer - BD Cantoll YG	Conventional flow cytometer configured with a blue, red, and yellow-green laser, capable of a standard 8 color analysis.
Cytometry and Cell Sorting Core	Flow Cytometer - BD Cantoll V	Conventional flow cytometer configured with a blue, red, and violet laser, capable of a standard 8 color analysis.
Cytometry and Cell Sorting Core	Flow Cytometer - BD Symphony A5	Flow cytometer that can be configured with up to 5 lasers and up to 31 fluorescence channels for highly complex multi-parameter analysis.
Cytometry and Cell Sorting Core	Flow Cytometer - Cytek Aurora	Full spectrum flow cytometer that uses 5 lasers and APD detector arrays utilize complete emission spectrum of each fluorochrome, enabling the detection of over 40 colors.
Cytometry and Cell Sorting Core	Flow Cytometer - Cytek Northern Lights	Full spectrum flow cytometer that uses 3 lasers and APD detector arrays utilize complete emission spectrum of each fluorochrome, enabling the detection of over 20 colors.
Cytometry and Cell Sorting Core	Flow Cytometer - ThermoFisher AttuneNXT	Acoustic focusing flow cytometer that typically uses up to 4 lasers and can detect up to 14 colors for rapid and accurate cell analysis.
Cytometry and Cell Sorting Core	Imaging Flow Cytometer - Cytek ImageStreamX MkII	Imaging flow cytometer that combines traditional flow cytometry with high-speed imaging, using up to 4 lasers and capable of capturing up to 12 channels of images per cell.
Cytometry and Cell Sorting Core	Imaging Flow Cytometer - BD FACSDiscover A8	5 laser imaging and spectral flow cytometric cell analyzers, capable of analyzing individual cells for research applications

Core	Instrument	Description
Recombinant Protein Production and Characterization Core	AUC - Beckman	Analytical ultracentrifuge
Advanced Cell Engineering and 3D Models Core	Centrifuge - Eppendorf (x3)	General purpose Eppendorf centrifuges
Gene Vector Core	Centrifuge - Avanti JR15R	A high-speed refrigerated centrifuge used for separating larger sample volumes in a temperature-controlled environment.
Gene Vector Core	Centrifuge - Beckman Avanti JXN26	A high-speed, large volume centrifuge designed for purifying and separating cells and other biological samples.
Recombinant Protein Production and Characterization Core	Centrifuge - Sorvall LYNX 6000	Superspeed large volume centrifuge
Biofluids Repository Core	Centrifuge - Sorvall Legend Rt	General purpose floor standing centrifuge
Recombinant Protein Production and Characterization Core	Centrifuge - Sorvall X4FR	Refrigerated centrifuge
Biofluids Repository Core	Microcentrifuge - Hettich Mikro 22R	Refrigerated microcentrifuge
Gene Vector Core	Ultracentrifuge - Beckman Optima XPN 90	Standard ultracentrifuge
Gene Vector Core	Ultracentrifuge - Sorvall WX80	Standard ultracentrifuge
Mass Spectrometry Proteomics Core	Ultracentrifuge - Beckman Tabletop	A smaller volume tabletop ultracentrifuge

Core	Instrument	Description
MHC Tetramer Core	FPLC - AktaPure 25 L	Fast Protein Liquid Chromatography (FPLC) system specifically designed for high-resolution purification of proteins.
CryoEM and CryoET Core	FPLC - AktaPure	Fast Protein Liquid Chromatography (FPLC) system specifically designed for high-resolution purification of proteins.
Recombinant Protein Production and Characterization Core	FPLC - AktaPure	Fast Protein Liquid Chromatography (FPLC) system specifically designed for high-resolution purification of proteins.
Mass Spectrometry Proteomics Core	HPLC - Easy nLC 1200 (UHPLC)	Ultra-high-performance liquid chromatography (UHPLC) system that delivers nanoflow gradients for the separation of complex peptide mixtures in bottom-up proteomics workflows.
Mass Spectrometry Proteomics Core	HPLC - Agilent Infinity 1260	High-performance liquid chromatography (HPLC) system used for offline peptide fractionation, improving proteome depth and coverage in bottom-up proteomics workflows.

Core	Instrument	Description
Bioengineering	Hermle 5-axis CNC Mill	Hermle 5-axis CNC Mill: A high-precision computer-controlled milling machine that can simultaneously move a cutting tool along five different axes to create complex, three-dimensional parts.
Bioengineering	Haas CNC Lathe	Haas CNC Lathe: A computer-controlled turning machine that rotates a workpiece to create cylindrical parts.
Bioengineering	Thorlabs Optical Workstation	Thorlabs Optical Workstation: A workbench and support system for building and testing optical setups, experiments, and prototypes.
Bioengineering	Epilog Laser Cutter	Epilog Laser Cutter: A computer-controlled machine that uses a laser beam to precisely cut, engrave, or mark materials like wood, plastic, and paper.
Bioengineering	Stratasys 3-D Printer	Stratasys 3-D Printer: An additive manufacturing machine that builds three-dimensional palstic objects layer by layer from a 3D file.

Core	Instrument	Description
Mouse Metabolism and Phenotyping Core	Animal Monitoring - CLAMS (10 cage & 16 cage)	Comprehensive Lab Animal Monitoring Systems used to measure metabolism, feeding, drinking, and activity in groups of mice.
Zebrafish	Aquatic Animal Tracker - Danio Vision	An automated tracking system designed to monitor and analyze the behavior and activity of zebrafish and other small aquatic animals.
Mouse Metabolism and Phenotyping Core	DEXA	Dual-energy X-ray absorptiometry, a scanning technology used to measure body composition, including bone mineral density, fat mass, and lean mass.
Mouse Metabolism and Phenotyping Core	IVIS X5	An in-vivo imaging system that uses bioluminescence and fluorescence to visualize and track cells or genetic activity within living animals.
Patient-derived Xenograft Core	IVIS Lumina X5 (x2)	In vivo imaging system using bioluminescence and fluorescence to visualize biological processes in small living animals.
Mouse Metabolism and Phenotyping Core	MRI - EchoMRI	A system that uses magnetic resonance to quickly and accurately measure body composition (fat, lean mass, free water) in live animals without sedation.
CAMRI	MRI - MR5 Magnetom Prisma Fit	Siemens 3T magnetic resonance imaging scanner used for advanced neuroimaging and clinical research with MR5 Headphones and MR4 32" screen
CAMRI	MRI - MR4 Magnetom Prisma Fit	Siemens 3T magnetic resonance imaging scanner at CAMRI used for advanced neuroimaging and clinical research.
Mouse Metabolism and Phenotyping Core	MRI - Bruker Pharmascan 7T	Small animal (mouse) MRI - Bruker Pharmascan 7T with Paravision 4 console
Mouse Metabolism and Phenotyping Core	IITC NIBP	A non-invasive blood pressure monitoring system used for conscious or anesthetized small animals.
Zebrafish	Swim Tunnel - Loligo	Measures the metabolic rate of aquatic animals by forcing them to swim against a controlled water current.
Patient-derived Xenograft Core	Ultrasound - Vega	Easy-to-use ultrasound system enables high-speed and high-throughput imaging,. requires minimal training.
Mouse Metabolism and Phenotyping Core	Ultrasound - Vevo F2	A high-resolution ultrasound imaging system used for real-time, in-vivo imaging of small animals.
Mouse Metabolism and Phenotyping Core	XFe96	Measures the metabolic rates of cells by analyzing oxygen consumption and extracellular acidification in a 96-well plate format.
Optical Imaging and Vital Microscopy Core	Macromolecular X-Ray Crystallography Core MicroCT - Bruker Skyscan 1272	A high-resolution Macromolecular X-Ray Crystallography Core micro-CT scanner used for non-destructive 3D imaging of biological samples.
Mouse Metabolism and Phenotyping Core	Mediso Nanoscan SPECT/CT/PET	Combination unit for simultaneous anatomical and functional nuclear medicine imaging in animals

Core	Instrument	Description
Antibody-Based Proteomics Core	Arrayer - Quanterix 2470	Precisely prints tiny amounts of biological samples onto a surface for analysis.
Antibody-Based Proteomics Core	Arrayer - Aushon 2470	Precisely prints tiny amounts of biological samples onto a surface for analysis.
Biofluids Repository Core	FACS Lyse Wash Assistant	Lyses, mixes, washes, and fixes samples in preparation for flow cytometry.
Recombinant Protein Production and Characterization Core	Microfluidizer - Small Volume Model LM20-30	Microfluidizer - Small Volume Model LM20-30: An instrument that uses high-pressure fluid streams to create uniform emulsions and dispersions on a very small scale.
Biofluids Repository Core	Plate Washer - Tecan Hydrospeed	Automated microplate washer
Mass Spectrometry Proteomics Core	Robot - Agilent BRAVO AssayMAP	Automated liquid handling platform specifically designed for sample preparation for mass spectrometry and other analytical applications.
Advanced Cell Engineering and 3D Models Core	Robot - Beckman Biomek NX	Robotic liquid handling system used for automating a wide range of tasks in molecular biology, such as pipetting and sample preparation.
Integrated Microscopy Core	Robot - Beckman i5	High-throughput robotic system used to automate laboratory workflows, especially for genomics and drug screening.
Recombinant Protein Production and Characterization Core	Robot - Clonacell Easy Pick Starlet, Hamilton	Robotic system for the automated picking of bacterial or yeast colonies from agar plates.
Single Cell Genomics Core	Robot - Connect (single cell)	Automated liquid handling system (support will end on 2027)
Biofluids Repository Core	Robot - Opentrons OT2 Robotic Pipetting System	High precision, open-source liquid handler
Genetically Engineered Rodent Models Core	Robot - QIAgility System HEPA / UV with laptop	Robotic pipetting system that automates the setup of quantitative PCR, minimizing human error.
RNA-In Situ Hybridization Core	Robot - Tecan EVO Genepaint	Robot for for in situ hybridization (ISH) and fluorescence in situ hybridization (FISH)
Genomic and RNA Profiling Core	Robotic Workstation - Hamilton NGS Star	Robotic workstation for automating next-generation sequencing (NGS) sample preparation, from library prep to normalization.

Core	Instrument	Description
Recombinant Protein Production and Characterization Core	BLI - Octet	Bio-Layer Interferometry (BLI) technology for real-time, label-free analysis of molecular interactions, such as protein-protein binding.
Recombinant Protein Production and Characterization Core	DLS	Dynamic light scattering used to determine molecular weight, size distributions, and conformation of molecules in solution.
Recombinant Protein Production and Characterization Core	DSF	Differential Scanning Fluorimetry, a technique used to measure the thermal stability of proteins.
NMR and Drug Metabolism Core	Imaging MS - Bruker tims TOF MALDI 2 Flex IMS	Imaging mass spectrometer that uses ion mobility spectrometry to add an extra dimension of separation, improving the analysis of complex samples.
Recombinant Protein Production and Characterization Core	ITC - Malvern	Isothermal titration calorimetry to measure molecular interactions, such as protein-protein binding.
Recombinant Protein Production and Characterization Core	MALS - Mals Systems	Multi-angle light scattering systems (size-exclusion SEC or composition gradient CG) used to determine the absolute molecular weight, size, and conformation of molecules in solution.
Cytometry and Cell Sorting Core	Mass Cytometer - Standard Biotools Helios/Hyperion	Mass cytometer (CyTOF) that use a mass spectrometer to analyze cells and tissue slides labeled with heavy metal isotopes, allowing for the simultaneous detection of over 40 parameters.
Cytometry and Cell Sorting Core	Mass Cytometer - Standard Biotools CyTOF XTi	Mass cytometers (CyTOF) that use a mass spectrometer to analyze cells and tissue slides labeled with heavy metal isotopes, allowing for the simultaneous detection of over 40 parameters.
Mass Spectrometry Proteomics Core	MS - Thermo Fisher Orbitrap Fusion Lumos ETD	High-resolution tribrid mass spectrometer offering Orbitrap, ion trap, and quadrupole technologies, with ETD capability for in-depth protein identification, quantification, and post-translational modification analysis in bottom-up proteomics workflows.
Mass Spectrometry Proteomics Core	MS - ThermoFisher Orbitrap Exploris 480	High-resolution mass spectrometer with faster scanning Orbitrap offering in-depth protein identification and quantification in bottom-up proteomics workflow.
Mass Spectrometry Proteomics Core	MS - ThermoFisher Orbitrap Eclipse	Next-generation tribrid mass spectrometer with enhanced sensitivity and scan speed offering intelligent acquisition features such as real-time search for improved protein detection and quantification.
Mass Spectrometry Proteomics Core	MS - Bruker Tims TOF Ultra2	Next generation mass spectrometer that offers unmatched sensitivity for low input, single cell proteomics
Metabolomic Core	MS - AB SCIEX TripleTOF 5600 System	Hybrid mass spectrometer that combines a triple quadrupole with time-of-flight technology for high-speed, accurate mass analysis.
Metabolomic Core	MS - ThermoFisher IQ-X Orbitrap	High-resolution Orbitrap mass spectrometer optimized for small molecule analysis in fields like metabolomics and environmental testing.
Metabolomic Core	MS - Aglient QQQ 6495 LC-QQQ (3 instruments)	Tandem mass spectrometry systems (Liquid Chromatography-Triple Quadrupole) used for Targeted metabolomics and Targeted metabolic flux
Metabolomic Core	MS - SCIEX 7500 Plus TRAP Mass Spectrometry	Tandem mass spectrometry systems (Liquid Chromatography-Triple Quadrupole) used for highly sensitive and selective quantitation of target lipids
NMR and Drug Metabolism Core	MS - TSQ Quantis Quad	Triple quadrupole mass spectrometer designed for high-performance and high-throughput quantitation of molecules.
Biofluids Repository Core	Multiplex Analyzer- Luminex xMAP INTELLIFLEX	Multiplex protein and RNA analysis
Biofluids Repository Core	Multiplex Analyzer - Luminex MagPix	Multiplex protein and RNA analysis
Mass Spectrometry Proteomics Core	Spectrophotometer - Denovix DS-11	Compact spectrophotometer used to measure the concentration of nucleic acids (DNA/RNA) and proteins in very small sample volumes.

Core	Instrument	Description
Human Tissue Acquisition and Pathology Core	10x Genomics Visium Cytassist	An instrument for automated tissue processing and transfer for spatial transcriptomics, allowing for the mapping of gene expression in tissue sections.
Single Cell Genomics Core	10x Genomics Xenium	Instrument for spatial biology applications, allowing for the analysis of gene expression within the context of tissue location.
Integrated Microscopy Core	Bruker Vutara 352	A super-resolution microscope (not IMC service)
Integrated Microscopy Core	Cytation 5	A multi-mode microplate reader that combines plate reading with automated microscopy for cell-based assays.
Antibody-Based Proteomics Core	GenePix 4400AL Scanner	A microarray scanner used to analyze the results of DNA, protein, or other types of microarrays.
Genetically Engineered Rodent Models Core	EmbryoScope+ (ES+)	A time-lapse imaging system specifically designed to monitor and assess the development of embryos.
Macromolecular X-Ray Crystallography Core	Formulatrix Rock Imager 2 with UV/ Fluorescence Option	A robotic imaging system used to automatically capture images of protein crystallization plates.
Gene Vector Core	iBright 1500	Imaging system used to capture and analyze gels and western blots.
Integrated Microscopy Core	Incucyte S3	A live-cell analysis system that captures time-lapse images of cells growing inside an incubator.
Advanced Cell Engineering and 3D Models Core	IVIS Lumina 3	In vivo imaging system using bioluminescence and fluorescence to visualize biological processes in small living animals.
Human Stem Cell and Neuronal Differentiation Core	Keyence Microscope	Digital microscope with extended depth of field.
Zebrafish	Lecia Flurecence Dissecting Stereo Microscope	A dissecting microscope that can also perform fluorescence imaging.
Macromolecular X-Ray Crystallography Core	Lecia M125 C	A stereo microscope with high magnification and resolution.
Zebrafish	Lecia M125 C	A stereo microscope with high magnification and resolution.
Mouse Metabolism and Phenotyping Core	Leica M80	A stereo microscope used for high-quality, three-dimensional observation and documentation of samples.
Integrated Microscopy Core	Leica Stellaris	A confocal laser scanning microscope used for high-resolution, three-dimensional imaging of cells and tissues.
Optical Imaging and Vital Microscopy Core	Leica TCS SP8 MP	A confocal/multiphoton laser scanning microscope used for deep tissue imaging in living animals.
Optical Imaging and Vital Microscopy Core	Logos X-CLARITY System	Automates the tissue clearing with X-CLARITY protocol, making tissues transparent for 3D imaging.
Single Cell Genomics Core	Merscope	Instrument for spatial biology applications, allowing for the analysis of gene expression within the context of tissue location.
Advanced Cell Engineering and 3D Models Core	Motic Microscope	General purpose microscopes used for basic visualization and observation of samples.
Integrated Microscopy Core	Nanolive 3D CellExplorer	A specialized microscope that uses holographic index of refraction microscopy for label-free identification of organelles.
Integrated Microscopy Core	Nikon A1-Rs	A confocal laser scanning microscope used for high-resolution, three-dimensional imaging of cells and tissues.
Integrated Microscopy Core	Nikon Ci-L	An upright light microscope used for routine brightfield and phase contrast imaging.
Advanced Cell Engineering and 3D Models Core	Nikon Eclipse Flurescent Microscope	General purpose fluorescence microscope
Patient-derived Xenograft Core	Nikon Eclipse Flurescent Microscope	General purpose fluorescence microscope
Human Tissue Acquisition and Pathology Core	Nikon slide scanner	Whole slide imaging of tissue sections. Brightfield and fluorescent imaging.
Biofluids Repository Core	Nikon SMZ1000 Stereomicroscope	Standard stereo microscope
Integrated Microscopy Core	Olympus IX83	An inverted research microscope used for live-cell imaging and advanced microscopy techniques.
Human Tissue Acquisition and Pathology Core	Vectra 3 Upgrade	A system for multispectral pathology imaging, used to analyze multiple biomarkers on a single tissue slide.
RNA-In Situ Hybridization Core	Zeiss AxioScan: Z1 and 7 Slide Scanners	Whole slide imaging of tissue sections. Brightfield and fluorescent imaging.
Gene Vector Core	Zeiss Axiovert	An inverted microscope used for cells in culture plates and dishes
Genetically Engineered Rodent Models Core	Zeiss Axiovert	An inverted microscope used for cells in culture plates and dishes
Optical Imaging and Vital Microscopy Core	Zeiss AxioZoom	A hybrid stereo/compound fluorescence microscope that provides high-resolution imaging with a wide field of view.
Genetically Engineered Rodent Models Core	Zeiss CEROS II- Animal	System used for analyzing sperm motility and concentration in animal samples.
Optical Imaging and Vital Microscopy Core	Zeiss Lightsheet Z.1	A specialized fluorescence microscope that uses a thin sheet of light to rapidly image large, transparent samples with minimal damage.
Optical Imaging and Vital Microscopy Core	Zeiss LSM 880 Airyscan	Confocal laser scanning microscope with Airyscan super-resolution detection used for high-resolution 3D imaging of cells and tissues.
Integrated Microscopy Core	Yokogawa CV8000	A high-content imaging system used for automated screening and analysis of a large number of cells.

Core	Instrument	Description
Genomic and RNA Profiling Core	Automated Electrophoresis - Agilent Bioanalyzer 2100	Microfluidics-based system used to analyze the size, quantity, and quality of DNA, RNA, and protein samples.
Genomic and RNA Profiling Core	Automated Electrophoresis - Agilent TapeStation 2200	Automated electrophoresis system used for the quality control of nucleic acid samples.
Genomic and RNA Profiling Core	CE - Agilent Femto Pulse	Pulsed-field capillary electrophoresis system used for high-resolution analysis of large nucleic acid fragments.
Genetically Engineered Rodent Models Core	CE - Qiagen QIAxcel Advanced	Capillary electrophoresis system for the automated analysis and quality control of nucleic acids.
Genomic and RNA Profiling Core	DNA Shearing - Diagenode Megaruptor 3	Uniform DNA shearing for sequencing.
Genomic and RNA Profiling Core	DNA Sizing - Sage Science Pippin HT	Automated system for size-selecting DNA fragments, a crucial step in preparing sequencing libraries.
Genomic and RNA Profiling Core	DNA Sizing - Sage Science Blue Pippin	Automated system for size-selecting DNA fragments, a crucial step in preparing sequencing libraries.
Antibody-Based Proteomics Core	Multiplex Assay - Bio-Plex 200 & Luminex 200	Multiplexed bead-based assay systems used to simultaneously measure multiple analytes (e.g., proteins, nucleic acids) in a single sample.
Advanced Cell Engineering and 3D Models Core	PCR - ABI StepOnePlus qPCR	Quantitative real-time PCR (qPCR) system used to amplify and quantify nucleic acids as the reaction progresses.
Zebrafish	PCR - Bio-Rad CFX Opus 96 rtPCR	96 well 5 color + FRET Real time PCR system
Advanced Cell Engineering and 3D Models Core	PCR - Eppendorf	Standard PCR
Genetically Engineered Rodent Models Core	PCR - ProFlex 3X32	ProFlex 3X32-well PCR System: A versatile thermocycler with multiple independent blocks for running various PCR protocols simultaneously.
Genetically Engineered Rodent Models Core	PCR - QuantStudio 7 Flex 96W DSTP	A high-performance quantitative real-time PCR (qPCR) system for advanced gene expression and genotyping studies.
Genetically Engineered Rodent Models Core	PCR - QX200 ddPCR	Digital droplet PCR (ddPCR) system used for highly precise absolute quantification of nucleic acids.
Gene Vector	PCR - Stratagene MX3005P qPCR	Older quantitative real-time PCR (qPCR) system for gene expression analysis and genotyping.
Genomic and RNA Profiling Core	PCR - ViiA7 qRT-PCR instrument	Quantitative real-time PCR (qRT-PCR) system used for gene expression analysis and pathogen detection.
Gene Vector	Plate Reader - ClarioSTAR Plus	Multi-mode microplate reader used for a wide range of assays in life science research.
Advanced Cell Engineering and 3D Models Core	Plate Reader - LUMIStar Omega	Multi-label plate reader used to measure a variety of luminescence assays in microplates.
Genomic and RNA Profiling Core	Sequencer - Illumina iSeq 100	DNA sequencing system that use different scales of throughput to sequence genomes, transcriptomes, and other genetic material.
Genomic and RNA Profiling Core	Sequencer - Illumina NovaSeq X	DNA sequencing system that use different scales of throughput to sequence genomes, transcriptomes, and other genetic material.
Genomic and RNA Profiling Core	Sequencer - Oxford Nanopore Promethion 24	High-throughput DNA and RNA sequencing device that uses nanopore technology for long-read sequencing.
Single Cell Genomics Core	Single Cell Partitioning - Chromium Controller 10915	Microfludics system performing single cell partitioning and barcoding (old version, support will end on 2027)
Single Cell Genomics Core	Single Cell Partitioning - Chromium Controller 12239	Microfludics system performing single cell partitioning and barcoding (old version, support will end on 2027)
Single Cell Genomics Core	Single Cell Partitioning - Chromium X	Microfludics system performing single cell partitioning and barcoding (newer version of chromium controller)
Advanced Cell Engineering and 3D Models Core	Spectrophotometer - Nanodrop 8000	UV-Vis spectrophotometer

Core	Instrument	Description
CryoEM and CryoET Core	CryoEM and CryoET Core - JEOL JEM2100	A 200keV LaB6 CryoEM and CryoET Core with a DE12 camera for initial specimen screening
CryoEM and CryoET Core	CryoEM and CryoET Core - JEOL JEM2200FS	A 200keV CryoEM and CryoET Core with a field emission gun and a DE20 camera. Limited to ~5-7 Å resolution.
CryoEM and CryoET Core	CryoEM and CryoET Core - JEOL JEM3200FSC	A 300keV CryoEM and CryoET Core with a field emission gun, energy filter and a K2 summit detector. Capable of ~3 Å resolution.
CryoEM and CryoET Core	CryoEM and CryoET Core - ThermoFisher Glacios	A 200keV CryoEM and CryoET Core with a field emission gun, an autoloader, a Falcon 4 and Apollo detectors, capable of ~2.5 Å resolution single particle analysis
CryoEM and CryoET Core	Cryo FIB/SEM - Thermofisher Aquilos 2 with IFLM and Lift-out	A second generation Cryo-FIB/SEM with 4-channel correlative wide-field fluorescence
CryoEM and CryoET Core	Cryo Grid Plunger - Leica	Grid vitrification robot with 1-sided blotting
CryoEM and CryoET Core	Cryo Grid Plunger - ThermoFisher Vitrobot	Grid vitrification robot with 2-sided blotting
CryoEM and CryoET Core	Cryo High Pressure Freezer - Leica EM-ICE	A high pressure freezer for rapid freezing of cellular/tissue specimens without freezing damage
Macromolecular X-Ray Crystallography Core	Crystallization robot - Mosquito	Robot to setup crystallization screening plates
CryoEM and CryoET Core	Glow Discharge	Used for grid preparation before specimen deposition in CryoEM and CryoET Core
NMR and Drug Metabolism Core	NMR - Bruker NMR 600 MHz	High-field nuclear magnetic resonance spectrometers used for molecular structure elucidation and analysis.
NMR and Drug Metabolism Core	NMR - Bruker NMR 800MHz	High-field nuclear magnetic resonance spectrometers used for molecular structure elucidation and analysis.
CryoEM and CryoET Core	Plasma Cleaner	Variety of purposes, primarily grid-prep before CryoEM and CryoET Core
CryoEM and CryoET Core	TEM - JEM1230	A 120 keV LaB6 TEM for room temperature imaging

Core	Instrument	Description
Human Tissue Acquisition and Pathology Core	Automated Film Coverslipper - Tissue-Tek	Automatically places a glass coverslip over a stained tissue section on a slide for permanent mounting.
Antibody-Based Proteomics Core	Autostainer - Link48 (x2)	An automated slide stainer for preparing tissue samples for immunohistochemistry (IHC) and other staining procedures.
Patient-derived Xenograft Core	Cassette Printer - Rankin	Prints identifying text and barcodes directly onto tissue cassettes, which hold samples during processing.
Human Tissue Acquisition and Pathology Core	Cryostat - Cryostar NX50	Cuts frozen tissue samples into very thin sections for microscopic examination.
Human Tissue Acquisition and Pathology Core	Cryostat - Microm 505E	Cuts frozen tissue samples into very thin sections for microscopic examination.
RNA-In Situ Hybridization Core	Cryostat - Leica CM3050	Cuts frozen tissue samples into very thin sections for microscopic examination.
Human Tissue Acquisition and Pathology Core	Laser Cassette Printer - Epredia FA-Tech	Prints identifying text and barcodes directly onto tissue cassettes, which hold samples during processing.
Human Tissue Acquisition and Pathology Core	Microtome - Leica 2135	Cuts thin slices of tissue for microscopic examination after the tissue has been processed and embedded in a block.
Genetically Engineered Rodent Models Core	Microinjector - Eppendorf™ FemtoJet™ 4i (x2)	A microinjection system used to inject very small volumes of fluids into cells or embryos.
Genetically Engineered Rodent Models Core	Micromanipulator - 3 Axis Joystick, MO202U, Narashige	Micromanipulator, 3 Axis Joystick, MO202U, Narashige: A precision instrument used for fine motor control to manipulate cells, tissues, or microscopic objects under a microscope.
Human Tissue Acquisition and Pathology Core	Slide Printer - Epredia Slidemate	An automated slide printer used to label microscope slides with text and barcodes.
Genomic and RNA Profiling Core	Sonicator - Covaris LE220	Uses high-frequency sound waves to shear DNA for sequencing, preparing chromatin, or disrupting cells.
Advanced Cell Engineering and 3D Models Core	Tissue Dissociator - GentleMACS	Uses a combination of mechanical force and enzymes to gently and automatically dissociate tissues into single-cell suspensions or smaller tissue fragments for downstream analysis
Patient-derived Xenograft Core	Tissue Dissociator - GentleMACS Octo	Uses a combination of mechanical force and enzymes to gently and automatically dissociate tissues into single-cell suspensions or smaller tissue fragments for downstream analysis
Advanced Cell Engineering and 3D Models Core	Tissue Lyser LT	A benchtop bead mill homogenizer that uses a high-speed shaking motion to lyse cells and tissues for molecular extraction.
Human Tissue Acquisition and Pathology Core	Tissue Processor - Tek VIP6	Automatically processes and prepares tissue samples for embedding and sectioning by dehydrating and clearing them.
Patient-derived Xenograft Core	Tissue Slicer	Used to slice or section tissue, often without embedding, for various types of analysis.
Genetically Engineered Rodent Models Core	Transfection System - Bulldog Bio NEPA21 Electro-Kinetic	NEPA21 Electro-Kinetic Transfection System (Bulldog Bio): A electroporation system that uses electrical pulses to introduce nucleic acids or other molecules into cells and embryos.

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All Core Equipment List

All Core Equipment List