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UV-Ligand Exchange Class I Monomers

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Media Component
Diagram showing the transformation of an MHC class I complex. A stable complex with a photolabile epitope becomes unstable after UV exposure (>350 nm), leading to disintegration or stabilization with a rescue peptide.
Content

Our UV-labile peptide–loaded Class I monomers provide a flexible platform for generating custom MHC tetramers. By exposing the monomers to UV light, the placeholder peptide is released and can be exchanged with your peptide of interest. This approach eliminates the need for new monomer preparations, saving time and resources while enabling broad peptide screening.

Why Choose Our Products?

  • Extensive coverage: Access a broad range of MHC alleles to fit diverse research needs.
  • Fast results: On-shelf availability and short turnaround times keep your projects moving.
  • Exclusive flexibility: Generate custom tetramers quickly with our UV-ligand exchange Class I monomers.
  • Cost savings: Take advantage of bulk order discounts for larger studies.
     

Available Alleles

For human: 

  • HLA-A*02:01
  • HLA-A*01:01
  • HLA-A*03:01
  • HLA-A*11:01
  • HLA-A*24:02
  • HLA-B*07:02
  • HLA-B*08:01
  • HLA-B*40:01
  • HLA-C*07:01
  • HLA-C*07:02

For mouse:

  • H-2Kb
  • H-2Db

Contact us lxwang@bcm.edu to learn more or discuss your project needs.

Other Information
MHC Tetramer Order Guidelines
MHC Tetramer Production Services