Study of Lofexidine and Buprenorphine for PTSD and opioid use (H-46489)

A Randomized, Double-Blind, Placebo-Controlled Study to determine if Lofexidine as an adjunct to BUP treatment improves symptoms of both OUD and PTSD

Our site is currently participating in "Lofexidine Combined with Buprenorphine for Reducing Symptoms of Post-Traumatic Stress Disorder and Opioid Use Relapse in Veterans and Non- Veterans."

The overall objective of the proposed study is to determine if lofexidine (LFX) as an adjunct to buprenorphine (BUP) treatment improves symptoms of both opioid use disorder (OUD) and Post-Traumatic Stress Disorder (PTSD). Other study objectives are to compare the safety, tolerability, and efficacy of BUP treatment alone, to BUP treatment with adjunct LFX, on measures of OUD and PTSD symptoms in Veterans and Non-Veterans.

Qualified participants will receive study-related care and study medication or placebo at no cost. Compensation for time and travel may be available. Please contact us for more information.