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Baylor College of Medicine

Microbiome-Bile Acid Cross-Talk as a Mechanism of Antipsychotic-Induced Weight Gain (H-44069)



Do bile acids affect weight gain in children taking Risperidone?


Antipsychotic medications are often used to treat mood swings, aggression, and sometimes psychosis. These medications are quite effective but can also cause side effects, especially weight gain. This study focuses on risperidone, an antipsychotic very often given to children. We are specifically asking if weight gain caused by risperidone is due to changes in the gut bacteria and chemicals made by the liver, called bile acids. This study is a collaboration between our lab and researchers at the University of California at Los Angeles and is funded by the National Institutes of Health.

What does the study entail?

  • Four in-person visits at our clinic. Each in-person visit lasts about 1-2 hours.
  • Study participation will last for six months. 
  • At each in-person visit, participants will be asked to complete some questionnaires. They will also undergo a blood draw and a brief physical exam, and will be asked to give us urine and stool samples. 
  • Participants are compensated $50-$270 depending on how much of the study they complete, in addition to reimbursement for transportation expenses, and provided a meal.

Study requirements 

  • Must be 4-17 years of age.
  • About to start treatment with risperidone, or have started within the past seven days. 


Chadi Calarge Lab

Phone 1: 832–824–5002

IRB: H-44069




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