Baylor College of Medicine

Microbiome-Bile Acid Cross-Talk as a Mechanism of Antipsychotic-Induced Weight Gain (H-44069)



Antipsychotic medications are often use to treat mood swings, aggression, and sometimes psychosis. These medications are quite effective but can also cause side effects, such as weight gain, which can sometimes be extreme. This study focuses on risperidone, an antipsychotic very often given to children. We are specifically asking if weight gain caused by risperidone is due to changes in the gut bacteria and chemicals made by the liver, called bile acids. We are enrolling children and teens between the ages of 4 and 17 years old who will start treatment with Risperidone. This study involves 4 clinic visits over the span of 6 months, collection of blood, urine, and stool samples, a brief physical exam, and questionnaires for both participants and the parents to complete. We provide compensation between $50 and $270 and reimbursement for transportation expenses. This study is a collaboration between researchers at Baylor College of Medicine and the University of California at Los Angeles and is funded by the National Institutes of Health.


Chadi Calarge Lab

Phone 1: 832–824–5002

IRB: H-44069




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