Research within the Chemical, Physical and Structural Biology graduate program spans a wide-range of topics, yet is unified by a focus on delving into biochemistry, biophysics or structural basis of biological mechanisms in human health and disease.
Our program has a long history of cutting-edge, highly impactful contributions to science, a reputation that you will benefit from and contribute to. There are extensive state-of-the-art equipment and core facilities to enable your research endeavors.
Learn about our core research areas below and find faculty members whose interest match your own.
Computational Biophysics and Bioinformatics
Cryo-EM and Cryo-Electron Tomography
Drug Resistance Mechanisms
Gene Regulation, Chromatin and Epigenetics
High Throughput Screening
Metabolism and Metabolomics
Organic Synthesis and Medicinal Chemistry
Single-Molecule and Super-Resolution Fluorescence
Spectroscopy and Biophysical Methods
"I loved basic science as an undergraduate, but also wanted to focus on research that was going to impact people. It was clear when I was researching schools that BCM researchers valued collaborations with clinicians, and being in the TMC offers so much opportunity for such collaborations." - Elizabeth Bowling, Ph.D. Student
As a student in the Chemical, Physical and Structural Biology graduate program you will have access to the all the resources of Baylor College of Medicine as well as those of leading research institutions in the world's largest medical complex.
- Center for Drug Discovery
The CDD includes a state-of-the-art screening facility to perform screening for a wide range of cell-based phenotypic and target-based biochemical assays in high-throughput or follow-up screens.
- CryoEM Core
The CryoEM Core is a state-of-the-art resource for near-atomic resolution 3-D analysis of the structure and dynamics of macromolecules and assemblies, either purified or within cells.
- Mass Spectrometry Proteomics
The Mass Spectrometry (MS) Proteomics Core provides full “beginning-to-end” support that includes project evaluation and design, biochemical purifications, mass spectrometry sequencing, and data analysis performed within the core and by the experienced core personnel.
- Macromolecular X-Ray Crystallography Facility
The Macromolecular X-Ray Crystallography Facility provides a centralized, state-of-the-art resource for the acquisition of atomic resolution, 3D structure information of macromolecules, including proteins, nucleic acids, and their complexes with small molecule inhibitors.
- NMR and Drug Metabolism Core
The NMR and Drug Metabolism Core offers tools to support the discovery, synthesis, screening, optimization, metabolism and pharmacokinetics of small molecule ligands or lead compounds.
- Other Advanced Technology Cores
The Advanced Technology Core laboratories listed above are ones most utilized by faculty and students in our program. Depending on your area of focus, you may use others as well. These cores provide state-of-the-art instrumentation and technologies as well as consultation on experimental design, data analysis and training. Through the cores, you will not only gain access to tools and techniques that support your research, you will also receive training and mentorship in how to leverage these tools to develop innovative approaches to scientific challenges.
- More Research Resources
As you begin your career in research it is impossible to predict where your investigations will need. Therefore it is essential to have access to diverse resources, not only equipment but also experienced individuals available to help you identify the resources you need and master their use.