Kimberley Renee Fuchs Tolias, Ph.D.
Picture
Positions
- Professor
-
Department of Neuroscience
Baylor College of Medicine
Houston, TX US
- Professor
-
Department of Biochemistry and Molecular Biology
Baylor College of Medicine
Houston, TX US
Education
- PhD from Harvard Medical School
- 05/1998 - Boston, MA US
- Cell Biology - Signal Transduction
- Post-Doctoral Fellowship at Harvard Medical School
- 09/2006 - Boston, MA US
- Neuroscience
- Post-Doctoral Fellowship at Harvard Medical School
- 09/1999 - Boston, MA US
- Cell Biology - Signal Transduction
- BS from University of Minnesota
- 05/1992 - Minneapolis, MN US
- Biochemistry
Professional Interests
- Molecular and cellular mechanisms regulating neural circuit formation and plasticity
Professional Statement
The long-term goal of research in the laboratory is to understand the molecular and cellular mechanisms that control neural circuit formation and plasticity. We are particularly interested in elucidating novel signal transduction pathways that regulate essential neurodevelopmental and regenerative processes such as synaptogenesis, dendritic and axonal growth and guidance, and cell migration. In addition to investigating how these processes are normally regulated, we are examining how defects in these pathways contribute to neurological disorders such as autism spectrum disorder and intellectual disabilities and whether targeting these pathways can promote recovery following nervous system injury or disease. To accomplish these goals, we utilize both in vitro and in vivo rodent models and employ a wide variety of state-of-the-art genetic, molecular, cellular, biochemical, electrophysiological, and behavioral approaches.Websites
Selected Publications
- Cadwell, C.R., Palasantza, A., Jiang, X., Berens, P., Deng, Q., Yilmaz, M., Reimer, J., Shen, S., Bethge, M., Tolias, K. F., Sandberg, R., Tolias, A.S. "Electrophysiological, transcriptomic and morphologic profiling of single neurons using Patch-seq." Nat Biotechnol.. 2015 Dec 21;
- Um, K., Niu, S., Duman, J. G., Cheng, J., Tu, Y-K., Schwechter, B., Liu, F., Hiles, L., Narayanan, A., Ash, R. T. Mulherkar, S., Alpadi, K., Smirnakis, S. M., Tolias, K. F. "Dynamic control of excitatory synapse development by a Rac1 GEF/GAP regulatory complex." Dev Cell. 2014;29(6):701-715. Pubmed PMID: 24960694
- Duman, JG, Mulherkar, S., Tu, YK., Cheng, J., Tolias, K.F. "Mechanisms for spatiotemporal regulation of Rho-GTPase signaling at synapses." Neurosci Lett.. 2015 Aug 5;601:4-10. Pubmed PMID: 26003445
- Tolias KF, Duman JG, Um K "Control of synapse development and plasticity by Rho GTPase regulatory proteins.." Prog. Neurobiol.. 2011 Jul;94(2):133-48. Pubmed PMID: 21530608
- Mulherkar, S., Uddin, M.D., Couvillon, A., Sillitoe, R., Tolias, K. F. "The small GTPases RhoA and Rac1 regulate cerebellar development by controlling cell morphogenesis, migration and foliation.." Dev. Biol.. 2014 Aug 14;Epub ahead of p. Pubmed PMID: 25128586
- Schwechter, B., Rosenmund, C., Tolias, K. F. "RasGRF2 Rac-GEF activity couples NMDA receptor calcium flux to enhanced synaptic transmission." Proc. Natl. Acad. Sci. USA. 2013 Aug 27;110(35):14462-14467. Pubmed PMID: 23940355
- Mulherkar, M., Liu, F., Chen, Q., Narayanan, A. S., Couvillon, A., Shine, H. D., Tolias, K. F. "The Small GTPase RhoA is Required for Proper Locomotor Circuit Assembly." PLoS One. 2013 Jun 25;8(6):e67015. Pubmed PMID: 23825607
- Narayanan, A. S., Reyes, S. B., Um, K., McCarty, J. H., Tolias, K. F. "The Rac-GAP Bcr is a novel regulator of the Par Complex that controls cell polarity." Mol Biol Cell.. 2013 Dec;24(24):3857-3868. Pubmed PMID: 24152735
- Duman, J. G., Tzeng, C. P., Tu, Y-K., Munjal, T., Schwechter, B., Ho, T., Tolias, K. F. "The Adhesion-GPCR BAI1 Regulates Synaptogenesis by Controlling the Recruitment of the Par3/Tiam1 Polarity Complex to Synaptic Sites." J Neurosci.. 2013 Apr 17;33(16):6964-6978. Pubmed PMID: 23595754
- Schwechter, B. and Tolias, K. F. "Cytoskeletal Mechanisms for Synaptic Potentiation." Commun Integr Biol.. 2013 Nov 1;6(6):e27343. Pubmed PMID: 24505509
- Reyes, S. B., Narayanan, A. S., Lee, H.S., Tchaicha, J. H., Aldape, K.D., Lang, F. F., Tolias, K. F., McCarty, J. H. "β8 Integrin Associates with RhoGDI1 to Suppress Activation of Rac1 and Cdc42 in Invasive Glioblastoma Cells." Mol. Biol. Cell.. 2013 Feb;24(4):472-482. Pubmed PMID: 23283986
- Tolias, K. F.*, Bikoff, J.B.*, Burette, A., Paradis, S., Harrar, D., Tavazoie, S., Weinberg, R.J., Greenberg, M. E. "The Rac1-GEF, Tiam1, Couples the NMDA Receptor to the Activity-Dependent Development of Dendritic Arbors and Spines.." Neuron. 2005 Feb 17;45(4):525-538. Pubmed PMID: 15721239
- Tolias, K. F., Bikoff, J. B., Kane, C. G., Tolias, C. S., Hu, L., Greenberg, M. E. "The Rac1 guanine nucleotide exchange factor Tiam1 mediates EphB receptor-dependent dendritic spine development." Proc. Natl. Acad. Sci. USA. 2007 Apr 24;104(17):7265-7270. Pubmed PMID: 17440041
- Zhou, P., Porcionatto, M., Pilapil, M., Chen, Y., Choi, Y., Tolias, K. F., Bikoff, J. B., Hong, E.J., Greenberg, M. E., Segal, R. A. "Polarized Signaling Endosomes Coordinate BDNF-induced Chemotaxis of Cerebellar Precursors." Neuron. 2007 Jul 5;55(1):53-68. Pubmed PMID: 17610817
- Saito, K.*, Tolias, K. F.*, Saci, A., Koon H.B., Humphries, L.A., Scharenberg, A., Rawlings, D.J., Kinet, J-P and Carpenter, C. L. "BTK Regulates PtdIns-4,5-P2 Synthesis: Importance for Calcium Signaling and PI3K Activity." Immunity. 2003 Nov;19(5):669-78. Pubmed PMID: 14614854
- Tolias, K. F., Hartwig, J. H., Ishihara, H., Shibasaki, Y., Cantley, L. C., Carpenter, C. L. "Type I alpha phosphatidylinositol-4-phosphate 5-kinase mediates Rac-dependent actin assembly." Curr. Biol.. 2000;10(3):153-156. Pubmed PMID: 10679324
- Tolias, K. F., Rameh, L. E., Ishihara, H., Shibasaki, Y., Chen, J., Prestwich, G. D., Cantley, L. C., Carpenter, C. L. "Type I phosphatidylinositol-4-phosphate 5-kinases synthesize the novel lipids phosphatidylinositol-3,5-bisphosphate and phosphatidylinositol-5-phosphate." J. Biol. Chem.. 1998;273:18040-18046. Pubmed PMID: 9660759
- Tolias, K. F., Couvillon, A. D., Cantley, L. C., Carpenter, C. L. "Characterization of a Rac1- and RhoGDI-associated lipid kinase signaling complex." Mol. Cell Biol.. 1998;18:762-770. Pubmed PMID: 9447972
- Rameh, L. E., Tolias, K. T., Duckworth, B., Cantley, L. C. "A new pathway for phosphatidylinositol-4,5-bisphosphate synthesis." Nature. 1997;390:192-196. Pubmed PMID: 9367159
- Kost, B., Lemichez, E., Spielhofer, P., Hong, Y., Tolias, K. F., Carpenter, C. L., Chua, N-H. "Rac homologues and compartmentalized phosphatidylinositol 4,5-bisphosphate act in a common pathway to regulate polar pollen tube growth." J. Cell Biol.. 1999;145:317-330. Pubmed PMID: 10209027
- Tolias, K. F., Cantley, L. C., and Carpenter, C. L. "Rho family GTPases bind to phosphoinositide kinases." J Biol Chem.. 1995;270(30):17656-9. Pubmed PMID: 7629060
- Kolluri, R., Tolias, K. F., Carpenter, C. L., Rosen, F. S., Kirchhausen, T. "Direct interaction of the Wiskott-Aldrich syndrome protein with the GTPase Cdc42.." Proc Natl Acad Sci U S A.. 1996;93(11):5615-8. Pubmed PMID: 8643625
- Berditchevski, F, Tolias, K. F., Wong, K, Carpenter, C. L., Hemler, M. E. "A novel link between integrins, transmembrane-4 superfamily proteins (CD63 and CD81), and phosphatidylinositol 4-kinase." J. Biol. Chem.. 1997 Jan 31;272(5):2595-258. Pubmed PMID: 9006891
- Tolias, K. F. and Cantley, L. C. "Pathways for Phosphoinositide Synthesis." Chem. Phys. Lipids. 1999;98:69-77. Pubmed PMID: 10358929
- Tolias, K. F. and Carpenter, C. L. "In vitro interaction of phosphoinositide-4-phosphate 5-kinases with Rac." Methods Enzymol.. 2000;325:190-200. Pubmed PMID: 11036604
- Carpenter CL, Tolias KF, Van Vugt A, Hartwig J. "Lipid kinases are novel effectors of the GTPase Rac1." Adv Enzyme Regul.. 1999;39:299-312. Pubmed PMID: 10470380
- Carpenter CL, Tolias KF, Couvillon AC, Hartwig JH. "Signal transduction pathways involving the small G proteins rac and Cdc42 and phosphoinositide kinases.." Adv Enzyme Regul.. 1997;37:377-90. Pubmed PMID: 9381982
Log In to edit your profile
