Chad William Johnston, Ph.D.

Faculty

Email

chad.johnston@bcm.edu

Positions

Faculty: Pharmacology & Chemical Biology; Molecular Virology & Microbiology
Baylor College of Medicine

Education

Postdoctoral Fellowship at Massachusetts Institute of Technology: 05/2021 - Cambridge, Massachusetts, United States; Synthetic Biology

PhD from McMaster University: 04/2016 - Hamilton, Ontario, Canada; Biochemistry

BSc from McMaster University: 04/2016 - Hamilton, Ontario, Canada; Biochemistry

Professional Interests

Chemical Biology
Microbial Natural Products
Directed Evolution
Synthetic Biology
Antibiotic Discovery
LCMS

Websites

The Johnston Lab

Selected Publications

Johnston CW*, Wyatt MA*, Li X, Ibrahim A, Shuster J, Southam G, Magarvey NA.. " Gold biomineralization by a metallophore from a gold-associated microbe " Nat Chem Biol.. 2013 ; 9
Pubmed PMID: 23377039.
Skinnider MA*, Johnston CW*, Edgar RE, Dejong CA, Merwin NJ, Rees PN, Magarvey NA.. " Genomic charting of ribosomally synthesized natural product chemical space facilitates targeted mining " Proc Natl Acad Sci U S A.. 2016 ; 113
Pubmed PMID: 27698135.
Yang L*, Ibrahim A*, Johnston CW*, Skinnider MA, Ma B, Magarvey NA.. " Exploration of nonribosomal peptide families with an automated informatic search algorithm " Chem Biol.. 2015 ; 22
Pubmed PMID: 26364933.
Johnston CW, Badran AH, Collins JJ.. " Continuous bioactivity-dependent evolution of an antibiotic biosynthetic pathway " Nat Commun.. 2020 ; 11
Pubmed PMID: 32826900.
Skinnider MA, Johnston CW, Gunabalasingam M, Merwin NJ, Kieliszek AM, MacLellan RJ, Li H, Ranieri MRM, Webster ALH, Cao MPT, Pfeifle A, Spencer N, To QH, Wallace DP, Dejong CA, Magarvey NA.. " Comprehensive prediction of secondary metabolite structure and biological activity from microbial genome sequences " Nat Commun.. 2020 ; 11
Pubmed PMID: 33247171.
Johnston CW, Skinnider MA, Dejong CA, Rees PN, Chen GM, Walker CG, French S, Brown ED, Bérdy J, Liu DY, Magarvey NA.. " Assembly and clustering of natural antibiotics guides target identification " Nat Chem Biol.. 2016 ; 12
Pubmed PMID: 26829473.
Johnston CW*, Skinnider MA*, Wyatt MA, Li X, Ranieri MR, Yang L, Zechel DL, Ma B, Magarvey NA.. " An automated Genomes-to-Natural Products platform (GNP) for the discovery of modular natural products " Nat Commun.. 2015 ; 6
Pubmed PMID: 26412281.