Eric Van Nostrand, Ph.D.
Assistant Professor
Positions
- Assistant Professor
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Biochemistry
Baylor College of Medicine
Education
- PhD from Stanford University School of Medicine
- 09/2012 - Stanford, California, United States
- BS from Massachusetts Institute of Technology
- 06/2005 - Cambridge, Massachusetts, United States
- Postdoctoral Fellowship at University of California San Diego
- 03/2020 - La Jolla, California, United States
Professional Interests
- RNA genomics technologies
- Mechanisms of RNA processing
- Host:RNA viral interactions
- Bioinformatics
Professional Statement
I am an Assistant Professor in the Department of Biochemistry and Molecular Biology, and member of the Therapeutic Innovation Center.
“I know that mutation of my RNA binding protein causes disease – but how do I know which of thousands of targets drive this phenotype?” The simplicity of this question belies the challenges involved in both identifying the direct and regulatory targets of the RNA binding protein (RBP), as well as narrowing the list of (often thousands or more) targets down to a set of phenotypically-relevant ones. My group uses a variety of genomics, molecular biology, and computational approaches to map and understand RNA processing regulatory networks, with the goals of uncovering new mechanisms in RNA processing and characterizing their roles in human physiology. We particularly focus on two biological systems: how RNA viruses hijack host RNA processing machineries to ensure proper replication and assembly, and how altered regulation of mRNA translation drives breast cancer.
“I know that mutation of my RNA binding protein causes disease – but how do I know which of thousands of targets drive this phenotype?” The simplicity of this question belies the challenges involved in both identifying the direct and regulatory targets of the RNA binding protein (RBP), as well as narrowing the list of (often thousands or more) targets down to a set of phenotypically-relevant ones. My group uses a variety of genomics, molecular biology, and computational approaches to map and understand RNA processing regulatory networks, with the goals of uncovering new mechanisms in RNA processing and characterizing their roles in human physiology. We particularly focus on two biological systems: how RNA viruses hijack host RNA processing machineries to ensure proper replication and assembly, and how altered regulation of mRNA translation drives breast cancer.
Selected Publications
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Song Z, Bae B, Schnabl S, Yuan F, De Zoysa T, Akinyi MV, Le Roux CA, Choquet K, Whipple AJ, Van Nostrand EL.. " Mapping snoRNA-target RNA interactions in an RNA-binding protein-dependent manner with chimeric eCLIP. " 2025 Feb 25; 26 (39)
Pubmed PMID: 40001124. -
Van Nostrand EL, Pratt GA, Yee BA, Wheeler EC, Blue SM, Mueller J, Park SS, Garcia KE, Gelboin-Burkhart C, Nguyen TB, Rabano I, Stanton R, Sundararaman B, Wang R, Fu XD, Graveley BR, Yeo GW. " Principles of RNA processing from analysis of enhanced CLIP maps for 150 RNA binding proteins " Genome Biology. 2020 Apr 6;
Pubmed PMID: 32252787. -
Van Nostrand EL*, Freese P*, Pratt GA*, Wang X*, Wei X*, Xiao R*, et al, Fu XD, Lécuyer E, Burge CB, Graveley BR, Yeo GW. " A Large-Scale Binding and Functional Map of Human RNA Binding Proteins " Nature. 2020 Jul ; 583 : 711-719.
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Yee BA, Pratt GA, Graveley BR, Van Nostrand EL†, Yeo GW†. " RBP-Maps enables robust generation of splicing regulatory maps " RNA. 2019 Feb ;
Pubmed PMID: 30413564.
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