Email

lyeoman@bcm.edu

Positions

Professor Emeritus

Pharmacology and Chemical Biology
Baylor College of Medicine
Houston, United States

Addresses

BCM-Michael DeBakey Center (Office)

Room: BCMM-220.17
Houston, TX, 77030
United States

Education

Advanced Training from Catholic University Of America

01/1991 - Washington, DC, United States

Advanced Training from Baylor College Of Medicine

01/1970 - Houston, TX, United States

Ph.D. from University Of Illinois, Urbana-Champaign

01/1970 - Urbana, IL, United States

B.A. from Depauw University

01/1965 - Greencastle, IN, United States

Websites

Selected Publications

• Yeoman LC, Olson MO, Sugano N, Jordan JJ, Taylor DW, Starbuck WC, Busch H. " Amino acid sequence of the center of the arginine-lysine-rich histone from calf thymus. The total sequence. " J. Biol. Chem.. 1972 Oct 10; 247 (19) : 6018-23.
  Pubmed PMID: 4568599.
• Sugano N, Olson MO, Yeoman LC, Johnson BR, Taylor CW, Starbuck WC, Busch H. " Amino acid sequence of the COOH-terminal portion of the arginine-lysine-rich histone of calf thymus. " J. Biol. Chem.. 1972 Jun 10; 247 (11) : 3589-91.
  Pubmed PMID: 4555425.
• Yeoman LC. " An autocrine model for cell- and matrix-associated fibroblast growth factor. " Oncol. Res.. 1993 ; 5 (12) : 489-99.
  Pubmed PMID: 8086671.
• Gross ME, Zorbas MA, Danels YJ, Garcia R, Gallick GE, Olive M, Brattain MG, Boman BM, Yeoman LC. " Cellular growth response to epidermal growth factor in colon carcinoma cells with an amplified epidermal growth factor receptor derived from a familial adenomatous polyposis patient. " Cancer Res.. 1991 Mar 1; 51 (5) : 1452-9.
  Pubmed PMID: 1847663.
• Lischwe MA, Cook RG, Ahn YS, Yeoman LC, Busch H. " Clustering of glycine and NG,NG-dimethylarginine in nucleolar protein C23. " Biochemistry. 1985 Oct 22; 24 (22) : 6025-8.
  Pubmed PMID: 4084504.
• Wan CW, McKnight MK, Brattain DE, Brattain MG, Yeoman LC. " Different epidermal growth factor growth responses and receptor levels in human colon carcinoma cell lines. " Cancer Lett.. 1988 Dec 1; 43 (41276) : 139-43.
  Pubmed PMID: 3264518.
• Novotny-Smith CL, Zorbas MA, Mcisaac AM, Irimura T, Boman BM, Yeoman LC, Gallick GE. " Down-modulation of epidermal growth factor receptor accompanies TNF-induced differentiation of the DiFi human adenocarcinoma cell line toward a goblet-like phenotype. " J. Cell. Physiol.. 1993 Nov ; 157 (2) : 253-62.
  Pubmed PMID: 8227158.
• Bhattycharyya L, Dabbah R, Hauck W, Sheinin E, Yeoman L, Williams R. " Equivalence studies for complex active ingredients and dosage forms. " AAPS J. 2005 ; 7 (4) : E786-812.
  Pubmed PMID: 16594632.
• Zorbas MA, Yeoman LC. " Growth control in a human colon carcinoma cell line mediated by cell-associated transforming growth factor-alpha (TGF alpha). " Exp. Cell Res.. 1993 May ; 206 (1) : 49-57.
  Pubmed PMID: 8482359.
• Brattain MG, Levine AE, Chakrabarty S, Yeoman LC, Willson JK, Long B. " Heterogeneity of human colon carcinoma. " Cancer Metastasis Rev.. 1984 ; 3 (3) : 177-91.
  Pubmed PMID: 6437669.
• Olson MO, Sugano N, Yeoman LC, Johnson BR, Jordan J, Taylor CW, Starbuck WC, Busch H. " Homology of the amino terminal sequences of the AL and GAR calf thymus histones. " Physiol. Chem. Phys.. 1972 ; 4 (1) : 41553.
  Pubmed PMID: 4667695.
• New BA, Yeoman LC. " Identification of basic fibroblast growth factor sensitivity and receptor and ligand expression in human colon tumor cell lines. " J. Cell. Physiol.. 1992 Feb ; 150 (2) : 320-6.
  Pubmed PMID: 1310324.
• Yeoman LC, Sebastian RV, Richards BF. " Inclusion of allied health students in a problem-based learning course. " Acad Med. 1998 May ; 73 (5) : 607-8.
  Pubmed PMID: 9643929.
• Andrus PL, Fasser CE, Yeoman L. " Interdisciplinary learning in pharmacology: analysis of M.D. and P.A. student performance. " J Med Educ. 1981 Sep ; 56 (9) : 757-61.
  Pubmed PMID: 6115945.
• Yeoman LC, Hager LP. " Isolation of a heme crevice peptide from affinity-labeled horseradish peroxidase. " Biochem. Biophys. Res. Commun.. 1980 Dec 16; 97 (3) : 1233-40.
  Pubmed PMID: 7470149.
• Yeoman LC, Danels YJ, Lynch MJ. " Lipofectin enhances cellular uptake of antisense DNA while inhibiting tumor cell growth. " Antisense Res. Dev.. 1992 ; 2 (1) : 51-9.
  Pubmed PMID: 1422086.
• Bennett CF, Yeoman LC. " Microinjected glutathione S-transferase Yb subunits translocate to the cell nucleus. " Biochem. J.. 1987 Oct 1; 247 (1) : 109-12.
  Pubmed PMID: 3689337.
• Brattain MG, Willson JK, Long BH, Chakrabarty S, Yeoman LC, Stringfellow DA. " Overcoming mitomycin C resistance with semisynthetic derivatives. " Prog. Clin. Biol. Res.. 1986 ; 223 : 63-79.
  Pubmed PMID: 3101070.
• Taylor CW, Kim YS, Childress-Fields KE, Yeoman LC. " Sensitivity of nuclear c-myc levels and induction to differentiation-inducing agents in human colon tumor cell lines. " Cancer Lett.. 1992 Feb 29; 62 (2) : 95-105.
  Pubmed PMID: 1540946.
• Yeoman LC, Wan CW, Zorbas MA. " Transferrin and insulin enhance human colon tumor cell growth by differentiation class specific mechanisms. " Oncol. Res.. 1996 ; 8 (41463) : 273-9.
  Pubmed PMID: 8938790.
• Untawale S, Zorbas MA, Hodgson CP, Coffey RJ, Gallick GE, North SM, Wildrick DM, Olive M, Blick M, Yeoman LC. " Transforming growth factor-alpha production and autoinduction in a colorectal carcinoma cell line (DiFi) with an amplified epidermal growth factor receptor gene. " Cancer Res.. 1993 Apr 1; 53 (7) : 1630-6.
  Pubmed PMID: 8453634.
• Williams RL. " US Pharmacopeia Council of Experts 2005-2010: work plans, new revision approaches, and other enhancements. " AAPS J. 2006 ; 8 (4) : E661-4.
  Pubmed PMID: 17285738.
• Yeoman LC, Jordan JJ, Busch RK, Taylor CW, Savage HE, Busch H. " A fetal protein in chromatin of Novikoff hepatoma and Walker 256 carcinosarcoma tumors that is absent from normal and regenerating rat liver. " Proc. Natl. Acad. Sci. U.S.A.. 1976 Sep ; 73 (9) : 3258-62.
  Pubmed PMID: 184470.
• Bennett FC, Yeoman LC. " An improved procedure for the 'dot immunobinding' analysis of hybridoma supernatants. " J. Immunol. Methods. 1983 Jul 15; 61 (2) : 201-7.
  Pubmed PMID: 6863946.
• Bennett FC, Busch H, Lischwe MA, Yeoman LC. " Antibodies to a nucleolar protein are localized in the nucleolus after red blood cell-mediated microinjection. " J. Cell Biol.. 1983 Nov ; 97 (5) : 1566-72.
  Pubmed PMID: 6355122.
• Busch H, Yeoman LC, Busch RK, Jordan JJ, Rao MS, Taylor CW, Wu BC. " Antigenically active nonhistone chromatin proteins in cancer cells. " Cancer Res.. 1976 Sep ; 36 (9) : 3399-408.
  Pubmed PMID: 184949.
• Pasternak M, Debrunner PG, Depasquali G, Hager LP, Yeoman L. " Application of I mossbauer effect to biological systems: studies with heme models. " Proc. Natl. Acad. Sci. U.S.A.. 1970 Aug ; 66 (4) : 1142-9.
  Pubmed PMID: 16591848.
• Huang KW, Moosic JP, Taylor CW, Lane M, Yeoman LC. " Characterization and reactivity of a monoclonal antibody that recognizes a 76 kilodalton human colon tumor antigen. " Cancer Lett.. 1988 Mar ; 39 (2) : 161-77.
  Pubmed PMID: 2452009.
• Catino JJ, Yeoman LC, Mandel M, Busch H. " Characterization of DNA binding protein from rat liver chromatin which decreases during growth. " Biochemistry. 1978 Mar 21; 17 (6) : 983-7.
  Pubmed PMID: 629956.
• Moosic JP, Mosley AM, Huang K, Taylor CW, Yeoman LC. " Characterization of two monoclonal antibodies that recognize high molecular weight colon antigens. " Cancer Lett.. 1989 Feb ; 44 (2) : 127-36.
  Pubmed PMID: 2920372.
• Goldberg AH, Yeoman LC, Busch H. " Chromatin-associated glycoproteins of normal rat liver and Novikoff hepatoma ascites cells. " Cancer Res.. 1978 Apr ; 38 (4) : 1052-6.
  Pubmed PMID: 205344.
• Bennett FC, Yeoman LC. " Co-localization of non-histone protein BA with U-snRNPs to the same regions of the cell nucleus. " Exp. Cell Res.. 1985 Apr ; 157 (2) : 379-86.
  Pubmed PMID: 2579834.
• Chakrabarty S, Taylor CW, Yeoman LC. " Comparison of immunoelectrophoretic techniques for the analysis of cytosol antigens. " J. Immunol. Methods. 1981 ; 43 (3) : 301-11.
  Pubmed PMID: 7252169.
• Cochran DL, Yeoman LC, Egle PM, Shelton KR. " Comparison of the major polypeptides of the erythrocyte nuclear envelope. " J. Supramol. Struct.. 1979 ; 10 (4) : 405-18.
  Pubmed PMID: 513770.
• Yeoman LC, Taylor CW, Jordan JJ, Busch H. " Differences in chromatin proteins of growing and non-growing tissues. " Exp. Cell Res.. 1975 Mar 1; 91 (1) : 207-15.
  Pubmed PMID: 165944.
• Yeoman LC, Seeber S, Taylor CW, Fernbach DJ, Falletta JM, Jordan JJ, Busch H. " Differences in chromatin proteins of resting and growing human lymphocytes. " Exp. Cell Res.. 1976 Jun ; 100 (1) : 47-55.
  Pubmed PMID: 1064554.
• Davis FM, Busch RK, Yeoman LC, Busch H. " Differences in nucleolar antigens of rat liver and Novikoff hepatoma ascites cells. " Cancer Res.. 1978 Jul ; 38 (7) : 1906-15.
  Pubmed PMID: 77722.
• Bremer JW, Busch H, Yeoman LC. " Evidence for a species of nuclear actin distinct from cytoplasmic and muscles actins. " Biochemistry. 1981 Mar 31; 20 (7) : 2013-7.
  Pubmed PMID: 6894385.
• Bennett FC, Rosenfeld BI, Huang CH, Yeoman LC. " Evidence for two conformational forms of nonhistone protein BA which differ in their affinity for DNA. " Biochem. Biophys. Res. Commun.. 1982 Jan 29; 104 (2) : 649-56.
  Pubmed PMID: 7073705.
• Levine AE, Hamilton DA, Yeoman LC, Busch H, Brattain MG. " Identification of a tumor inhibitory factor in rat ascites fluid. " Biochem. Biophys. Res. Commun.. 1984 Feb 29; 119 (1) : 76-82.
  Pubmed PMID: 6704134.
• Taylor CW, Chakrabarty S, Schauder KS, Yeoman LC. " Identification of cytosolic antigens from GW-39 adenocarcinoma cells by crossed immunoelectrophoresis and immunofluorescence. " Immunol. Commun.. 1983 ; 12 (3) : 315-29.
  Pubmed PMID: 6350166.
• Levine AE, McRae LJ, Hamilton DA, Brattain DE, Yeoman LC, Brattain MG. " Identification of endogenous inhibitory growth factors from a human colon carcinoma cell line. " Cancer Res.. 1985 May ; 45 (5) : 2248-54.
  Pubmed PMID: 3857117.
• Taylor CW, Yeoman LC. " Inhibition of colon tumor cell growth by 8-chloro-cAMP is dependent upon its conversion to 8-chloro-adenosine. " Anticancer Drugs. 1992 Oct ; 3 (5) : 485-91.
  Pubmed PMID: 1450443.
• James GT, Yeoman LC, Matsui S, Goldberg AH, Busch H. " Isolation and characterization of nonhistone chromosomal protein C-14 which stimulates RNA synthesis. " Biochemistry. 1977 May 31; 16 (11) : 2384-9.
  Pubmed PMID: 193558.
• Goldknopf IL, Taylor CW, Baum RM, Yeoman LC, Olson MO, Prestayko AW, Busch H. " Isolation and characterization of protein A24, a histone-like" non-histone chromosomal protein." " J. Biol. Chem.. 1975 Sep 25; 250 (18) : 7182-7.
  Pubmed PMID: 1165239.
• Busch H, Choi YC, Daskal I, Inagaki A, Olson MO, Reddy R, Ro-Choi TS, Shibata H, Yeoman LC. " Isolation and composition of nuclei and nucleoli. " Acta Endocrinol Suppl (Copenh). 1972 ; 168 : 35-66.
  Pubmed PMID: 4562656.
• Chakrabarty S, Taylor CW, Yeoman LC. " Isolation and partial characterization of a 700 kilodalton human colon carcinoma associated antigen. " Cancer Biochem. Biophys.. 1983 ; 6 (4) : 249-59.
  Pubmed PMID: 6616431.
• Taylor CW, Yeoman LC, Woolf LM, Busch H. " Isolation of a 70 000 molecular weight antigen of the Novikoff hepatoma. " Biochemistry. 1979 Sep 18; 18 (19) : 4049-54.
  Pubmed PMID: 114207.
• Busch GI, Yeoman LC, Taylor CW, Busch H. " Modified two-dimensional polyacrylamide gel electrophoresis systems for higher molecular weight nonhistone chromatin proteins from normal rat liver and Novikoff hepatoma ascites cells. " Physiol. Chem. Phys.. 1974 ; 6 (1) : 41284.
  Pubmed PMID: 4134968.
• Bennett CF, Spector DL, Yeoman LC. " Nonhistone protein BA is a glutathione S-transferase localized to interchromatinic regions of the cell nucleus. " J. Cell Biol.. 1986 Feb ; 102 (2) : 600-9.
  Pubmed PMID: 2935545.
• Michalik J, Yeoman LC, Busch H. " Nucleolar localization of protein B23 (37/5.1) by immunocytochemical techniques. " Life Sci.. 1981 Mar 23; 28 (12) : 1371-9.
  Pubmed PMID: 7017325.
• Lischwe MA, Roberts KD, Yeoman LC, Busch H. " Nucleolar specific acidic phosphoprotein C23 is highly methylated. " J. Biol. Chem.. 1982 Dec 25; 257 (24) : 14600-2.
  Pubmed PMID: 7174653.
• Taylor CW, Brattain MG, Yeoman LC. " Occurrence of cytosolic protein and phosphoprotein changes in human colon tumor cells with the development of resistance to mitomycin C. " Cancer Res.. 1985 Sep ; 45 (9) : 4422-7.
  Pubmed PMID: 3928156.
• Lischwe MA, Ochs RL, Reddy R, Cook RG, Yeoman LC, Tan EM, Reichlin M, Busch H. " Purification and partial characterization of a nucleolar scleroderma antigen (Mr = 34,000; pI, 8.5) rich in NG,NG-dimethylarginine. " J. Biol. Chem.. 1985 Nov 15; 260 (26) : 14304-10.
  Pubmed PMID: 2414294.
• Yeoman LC, Bremer JW. " Purification and properties of a 90-kDa nuclear actin-binding protein. " Proc. Soc. Exp. Biol. Med.. 1986 Apr ; 181 (4) : 479-85.
  Pubmed PMID: 3952079.
• Taylor CW, Yeoman LC, Jordan JJ, Goldknopf IL, Busch H. " Quantitative analysis of the distribution of 3H-leucine in acid soluble chromatin proteins of Noviknoff hepatoma cells separated by two-dimensional polyacrylamide gel electrophoresis. " Physiol. Chem. Phys.. 1976 ; 8 (1) : 41345.
  Pubmed PMID: 183225.
• Taylor CW, Brattain MG, Yeoman LC. " Rate of growth and extent of differentiation reflected by cytoplasmic proteins and antigens of human colon tumor cell lines. " Cancer Res.. 1984 Mar ; 44 (3) : 1200-5.
  Pubmed PMID: 6362859.
• Smetana K, Ochs RL, Busch RK, Yeoman LC, Busch H. " Studies on satellite nucleoli in rat hepatocytes and Novikoff hepatoma cells. " Cell Tissue Res.. 1987 Jul ; 249 (1) : 235-9.
  Pubmed PMID: 3621293.
• Catino JJ, Busch H, Daskal Y, Yeoman LC. " Subcellular localization of DNA-binding protein BA by immunofluorescence and immunoelectron microscopy. " J. Cell Biol.. 1979 Nov ; 83 (2) : 462-7.
  Pubmed PMID: 227916.
• Taylor CW, Yeoman LC, Busch H. " The isolation of nuclei with citric acid and the analysis of proteins by two-dimensional polyacrylamide gel electrophoresis. " Methods Cell Biol.. 1975 ; 9 : 349-76.
  Pubmed PMID: 166288.
• Nalty TJ, Yeoman LC. " Transfer of proteins from acrylamide gels to nitrocellulose paper after silver stain detection. " J. Immunol. Methods. 1988 Feb 24; 107 (1) : 143-9.
  Pubmed PMID: 2449504.
• Taylor CW, Yeoman LC, Daskal I, Busch H. " Two-dimensional electrophoresis of proteins of citric acid nuclei prepared with aid of a Tissumizer. " Exp. Cell Res.. 1973 Nov ; 82 (1) : 215-26.
  Pubmed PMID: 4356488.
• Yeoman LC, Taylor CW, Busch H. " Two-dimensional gel electrophoresis of acid-extractable nuclear proteins of regenerating and thioacetamide-treated rat liver, Morris 9618a hepatoma, and Walker 256 carcinosarcoma. " Cancer Res.. 1974 Feb ; 34 (2) : 424-8.
  Pubmed PMID: 4359383.
• Yeoman LC, Taylor CW, Woolf LM, Busch H. " Two-dimensional polyacrylamide gel analysis on nuclear proteins from human tumor cell lines. " Cancer. 1978 Aug ; 42 (2) : 474-82.
  Pubmed PMID: 567094.
• Yeoman LC, Taylor CW, Busch H. " Two-dimensional polyacrylamide gel electrophoresis of acid extractable nuclear proteins of normal rat liver and Novikoff hepatoma ascites cells. " Biochem. Biophys. Res. Commun.. 1973 Apr 16; 51 (4) : 956-66.
  Pubmed PMID: 4349999.
• Yeoman LC, Taylor CW, Jordan JJ, Busch H. " Two-dimensional polyacrylamide gel electrophoresis of chromatin proteins of normal rat liver and Novikoff hepatoma ascites cells. " Biochem. Biophys. Res. Commun.. 1973 Aug 21; 53 (4) : 1067-76.
  Pubmed PMID: 4356049.
• Nalty TJ, Taylor CW, Yeoman LC. " Variation in cytosolic protein expression between human colon tumors that differ with regard to differentiation class. " Clin. Chem.. 1988 Jan ; 34 (1) : 71-5.
  Pubmed PMID: 2448066.

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Intellectual Property

Detection of Human Cancer With a Monoclonal Antibody Specific for Antigen gp650

Product Patent #4,916,0565 (Approved)

Skills

pharmacology, medical education, problem-based learning, cancer prevention