Positions
- Assistant Professor
-
Pharmacology and Chemical Biology
Baylor College of Medicine
Houston, TX US
- Assistant Professor
-
Department of Pathology
Center for Drug Discovery
Houston, Texas USA
- Adjunct Assistant Professor
-
Chemistry
Rice University
Houston, Texas USA
- Member
-
Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas United States
Addresses
- BCM-Cullen Building (Office)
-
Room: BCMC-286A
Houston, TX 77030
United States
Education
- BS from Howard University
- District of Columbia, United States
- PhD from North Carolina State University
- Raleigh, North Carolina United States
- Post-Doctoral Fellowship at Harvard University and the Broad Institute of Harvard and MIT
- Cambridge, Massachusetts United States
Honors & Awards
- Scholar
- Cancer Prevention and Research Institute of Texas (01/2014 - 12/2014)
- Minority Predoctoral Fellowship
- NIH (01/2000 - 12/2004)
- U-Star Undergraduate Fellowship Program
- NIH (01/1998 - 12/1998)
- Undergraduate of the Year
- District of Columbia Institute of Chemists (01/1997 - 12/1997)
- Scholarship
- Lubrizol (01/1996 - 12/1997)
- Honors
- Howard University Department of Chemistry (01/1995 - 12/1998)
- Scholarship
- Monsanto (01/1995 - 12/1996)
- Trustee Scholarship
- Howard University (01/1993 - 12/1995)
Professional Interests
- Synthetic organic chemistry
- Fragment-based drug discovery
- Diversity-oriented synthesis
- Medicinal chemistry
- Chemical biology
Websites
Selected Publications
- Young DW, Comins DL "Tandem directed lithiations of N-Boc-1,2-dihydropyridines toward highly functionalized 2,3-dihydro-4-pyridones." Org. Lett. 2005 December 8; 7 (25): 5661-5664. Pubmed PMID: 16321016
- Kelly AR, Wei J, Kesavan S, Marie JC, Windmon N, Young DW, and Marcaurelle LA "Accessing skeletal diversity using catalyst control: formation of n and n+1 macrocyclic triazole rings.." Org. Lett.. 2009 11 (11): 2257-2260. Pubmed PMID: 2702139
- Young DW "Synthetic Chemistry: An upfront investment.." Nat. Chem. Bio.. 2010 6 (3): 174-175. Pubmed PMID: 20154664
- Dancik V, Seiler KP, Young DW, Schreiber SL, and Clemons PA. "Distinct biological network properties between the targets of natural products and disease genes.." J. Am. Chem. Soc.. 2010 132 (27): 9259-61. Pubmed PMID: 2898216
- Marcaurelle LA et al. "An aldol-based build/couple/pair strategy for the synthesis of medium- and large-sized rings: discovery of macrocyclic histone deacetylase inhibitors.." J. Am. Chem. Soc.. 2010 132 (47): 16962-76. Pubmed PMID: 3004530
- Hung AW, Ramek A, Wang Y, Kaya T, Wilson JA, Clemons PA, and Young DW. "Route to three-dimensional fragments using diversity-oriented synthesis.." Proc. Natl. Acad. Sci. USA. 2011 108 (17): 6799-804. Pubmed PMID: 3084099
- Wang Y, Jimenez M, Hansen AS, Raiber EA, Schreiber SL, and Young DW. "Control of olefin geometry in macrocyclic ring-closing metathesis reactions using a removable silyl group.." J. Am. Chem. Soc. 2011 133 (24): 9196-9. Pubmed PMID: 21557625
- Pandya BA, Dandapani S, Duvall JR, Rowley A, Mulrooney CA, Ryba T, Dombrowski M, Harton M, Young DW, and Marcaurelle LA. "Practical asymmetric synthesis of β-hydroxy γ-amino acids via complimentary aldol reactions.." Tetrahedron. 2011 67 (34): 6131-67. Pubmed PMID: 3150486
- Zhong C, Wang Y, Hung AW, Schreiber SL, and Young DW. "Diastereoselective control of intramolecular aza-Michael reactions using achiral catalysts.." Org. Lett.. 2011 13 (20): 5556-5559. Pubmed PMID: 21916463
- Wang Y, Jimenez J, Sheehan P, Zhong C, Hung AW, Tam CP, and Young DW. "Selective Access to Trisubstituted Macrocyclic E- and Z-Alkenes from the Ring-Closing Metathesis of Vinylsiloxanes.." Org. Lett.. 2013 15 (6): 1218-21. Pubmed PMID: 23448432
- Yuan Y, Hartland K, Boskovic Z, Wang Y, Walpita D, Zhong C, and Young DW, Kim Y-K, Tolliday NJ, Schreiber SL, and Wagner BK. "Chemical complementation of Pdx1 causes acquisition of beta cell-like characteristics in a human ductal cell line.." Chem. Biol.. 2013 20 (12): 1513-1522. Pubmed PMID: 24290880
- Zhong C, Wang Y, O’Herin C, and Young DW. "Synthesis of Substituted Morpholines Using Stereodivergent Aza-Michael Reactions Catalyzed by Brønsted Acids.." ACS Catalysis. 2013 15 (6): 643-46.
Funding
- Recruitment Award
- $2,000,000.00 (03/01/2014 - 03/01/2018) Grant funding from Cancer Prevention and Research Institute of Texas
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