Email

damian.young@bcm.edu

Positions

Assistant Professor

Pharmacology and Chemical Biology
Baylor College of Medicine
Houston, TX, US

Assistant Professor

Department of Pathology
Center for Drug Discovery
Houston, Texas, USA

Adjunct Assistant Professor

Chemistry
Rice University
Houston, Texas, USA

Member

Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas, United States

Addresses

BCM-Cullen Building (Office)

Room: BCMC-286A
Houston, TX, 77030
United States

Education

BS from Howard University

District of Columbia, United States

PhD from North Carolina State University

Raleigh, North Carolina, United States

Post-Doctoral Fellowship at Harvard University and the Broad Institute of Harvard and MIT

Cambridge, Massachusetts, United States

Honors & Awards

Scholar

Cancer Prevention and Research Institute of Texas (01/2014 - 12/2014)

Minority Predoctoral Fellowship

NIH (01/2000 - 12/2004)

U-Star Undergraduate Fellowship Program

NIH (01/1998 - 12/1998)

Undergraduate of the Year

District of Columbia Institute of Chemists (01/1997 - 12/1997)

Scholarship

Lubrizol (01/1996 - 12/1997)

Honors

Howard University Department of Chemistry (01/1995 - 12/1998)

Scholarship

Monsanto (01/1995 - 12/1996)

Trustee Scholarship

Howard University (01/1993 - 12/1995)

Professional Interests

• Synthetic organic chemistry
• Fragment-based drug discovery
• Diversity-oriented synthesis
• Medicinal chemistry
• Chemical biology

Websites

Selected Publications

• Young DW, Comins DL. " Tandem directed lithiations of N-Boc-1,2-dihydropyridines toward highly functionalized 2,3-dihydro-4-pyridones " Org. Lett. 2005 Dec 8; 7 (25) : 5661-5664.
  Pubmed PMID: 16321016.
• Kelly AR, Wei J, Kesavan S, Marie JC, Windmon N, Young DW, and Marcaurelle LA. " Accessing skeletal diversity using catalyst control: formation of n and n+1 macrocyclic triazole rings. " Org. Lett.. 2009 ; 11 (11) : 2257-2260.
  Pubmed PMID: 2702139.
• Young DW. " Synthetic Chemistry: An upfront investment. " Nat. Chem. Bio.. 2010 ; 6 (3) : 174-175.
  Pubmed PMID: 20154664.
• Dancik V, Seiler KP, Young DW, Schreiber SL, and Clemons PA.. " Distinct biological network properties between the targets of natural products and disease genes. " J. Am. Chem. Soc.. 2010 ; 132 (27) : 9259-61.
  Pubmed PMID: 2898216.
• Marcaurelle LA et al.. " An aldol-based build/couple/pair strategy for the synthesis of medium- and large-sized rings: discovery of macrocyclic histone deacetylase inhibitors. " J. Am. Chem. Soc.. 2010 ; 132 (47) : 16962-76.
  Pubmed PMID: 3004530.
• Hung AW, Ramek A, Wang Y, Kaya T, Wilson JA, Clemons PA, and Young DW.. " Route to three-dimensional fragments using diversity-oriented synthesis. " Proc. Natl. Acad. Sci. USA. 2011 ; 108 (17) : 6799-804.
  Pubmed PMID: 3084099.
• Wang Y, Jimenez M, Hansen AS, Raiber EA, Schreiber SL, and Young DW.. " Control of olefin geometry in macrocyclic ring-closing metathesis reactions using a removable silyl group. " J. Am. Chem. Soc. 2011 ; 133 (24) : 9196-9.
  Pubmed PMID: 21557625.
• Pandya BA, Dandapani S, Duvall JR, Rowley A, Mulrooney CA, Ryba T, Dombrowski M, Harton M, Young DW, and Marcaurelle LA.. " Practical asymmetric synthesis of β-hydroxy γ-amino acids via complimentary aldol reactions. " Tetrahedron. 2011 ; 67 (34) : 6131-67.
  Pubmed PMID: 3150486.
• Zhong C, Wang Y, Hung AW, Schreiber SL, and Young DW.. " Diastereoselective control of intramolecular aza-Michael reactions using achiral catalysts. " Org. Lett.. 2011 ; 13 (20) : 5556-5559.
  Pubmed PMID: 21916463.
• Wang Y, Jimenez J, Sheehan P, Zhong C, Hung AW, Tam CP, and Young DW.. " Selective Access to Trisubstituted Macrocyclic E- and Z-Alkenes from the Ring-Closing Metathesis of Vinylsiloxanes. " Org. Lett.. 2013 ; 15 (6) : 1218-21.
  Pubmed PMID: 23448432.
• Yuan Y, Hartland K, Boskovic Z, Wang Y, Walpita D, Zhong C, and Young DW, Kim Y-K, Tolliday NJ, Schreiber SL, and Wagner BK.. " Chemical complementation of Pdx1 causes acquisition of beta cell-like characteristics in a human ductal cell line. " Chem. Biol.. 2013 ; 20 (12) : 1513-1522.
  Pubmed PMID: 24290880.
• Zhong C, Wang Y, O’Herin C, and Young DW.. " Synthesis of Substituted Morpholines Using Stereodivergent Aza-Michael Reactions Catalyzed by Brønsted Acids. " ACS Catalysis. 2013 ; 15 (6) : 643-46.

Show 8 more publications

Funding

Recruitment Award

$2,000,000.00   (03/01/2014 - 03/01/2018)

Grant funding from Cancer Prevention and Research Institute of Texas