Positions
- Assistant Professor
-
Pharmacology and Chemical Biology
Baylor College of Medicine
Houston, TX US
- Assistant Professor
-
Department of Pathology
Center for Drug Discovery
Houston, Texas USA
- Adjunct Assistant Professor
-
Chemistry
Rice University
Houston, Texas USA
- Member
-
Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas United States
Addresses
- BCM-Cullen Building (Office)
-
Room: BCMC-286A
Houston, TX 77030
United States
Education
- BS from Howard University
- District of Columbia, United States
- PhD from North Carolina State University
- Raleigh, North Carolina United States
- Post-Doctoral Fellowship at Harvard University and the Broad Institute of Harvard and MIT
- Cambridge, Massachusetts United States
Honors & Awards
- Scholar
- Cancer Prevention and Research Institute of Texas (01/2014 - 12/2014)
- Minority Predoctoral Fellowship
- NIH (01/2000 - 12/2004)
- U-Star Undergraduate Fellowship Program
- NIH (01/1998 - 12/1998)
- Undergraduate of the Year
- District of Columbia Institute of Chemists (01/1997 - 12/1997)
- Scholarship
- Lubrizol (01/1996 - 12/1997)
- Honors
- Howard University Department of Chemistry (01/1995 - 12/1998)
- Scholarship
- Monsanto (01/1995 - 12/1996)
- Trustee Scholarship
- Howard University (01/1993 - 12/1995)
Professional Interests
- Synthetic organic chemistry
- Fragment-based drug discovery
- Diversity-oriented synthesis
- Medicinal chemistry
- Chemical biology
Websites
Selected Publications
- Young DW, Comins DL "Tandem directed lithiations of N-Boc-1,2-dihydropyridines toward highly functionalized 2,3-dihydro-4-pyridones." Org. Lett.2005/December8;7(25):5661-5664. Pubmed PMID: 16321016
- Kelly AR, Wei J, Kesavan S, Marie JC, Windmon N, Young DW, and Marcaurelle LA "Accessing skeletal diversity using catalyst control: formation of n and n+1 macrocyclic triazole rings.." Org. Lett..2009;11(11):2257-2260. Pubmed PMID: 2702139
- Young DW "Synthetic Chemistry: An upfront investment.." Nat. Chem. Bio..2010;6(3):174-175. Pubmed PMID: 20154664
- Dancik V, Seiler KP, Young DW, Schreiber SL, and Clemons PA. "Distinct biological network properties between the targets of natural products and disease genes.." J. Am. Chem. Soc..2010;132(27):9259-61. Pubmed PMID: 2898216
- Marcaurelle LA et al. "An aldol-based build/couple/pair strategy for the synthesis of medium- and large-sized rings: discovery of macrocyclic histone deacetylase inhibitors.." J. Am. Chem. Soc.. 2010 132 (47): 16962-76. Pubmed PMID: 3004530
- Hung AW, Ramek A, Wang Y, Kaya T, Wilson JA, Clemons PA, and Young DW. "Route to three-dimensional fragments using diversity-oriented synthesis.." Proc. Natl. Acad. Sci. USA. 2011 108 (17): 6799-804. Pubmed PMID: 3084099
- Wang Y, Jimenez M, Hansen AS, Raiber EA, Schreiber SL, and Young DW. "Control of olefin geometry in macrocyclic ring-closing metathesis reactions using a removable silyl group.." J. Am. Chem. Soc. 2011 133 (24): 9196-9. Pubmed PMID: 21557625
- Pandya BA, Dandapani S, Duvall JR, Rowley A, Mulrooney CA, Ryba T, Dombrowski M, Harton M, Young DW, and Marcaurelle LA. "Practical asymmetric synthesis of β-hydroxy γ-amino acids via complimentary aldol reactions.." Tetrahedron. 2011 67 (34): 6131-67. Pubmed PMID: 3150486
- Zhong C, Wang Y, Hung AW, Schreiber SL, and Young DW. "Diastereoselective control of intramolecular aza-Michael reactions using achiral catalysts.." Org. Lett.. 2011 13 (20): 5556-5559. Pubmed PMID: 21916463
- Wang Y, Jimenez J, Sheehan P, Zhong C, Hung AW, Tam CP, and Young DW. "Selective Access to Trisubstituted Macrocyclic E- and Z-Alkenes from the Ring-Closing Metathesis of Vinylsiloxanes.." Org. Lett.. 2013 15 (6): 1218-21. Pubmed PMID: 23448432
- Yuan Y, Hartland K, Boskovic Z, Wang Y, Walpita D, Zhong C, and Young DW, Kim Y-K, Tolliday NJ, Schreiber SL, and Wagner BK. "Chemical complementation of Pdx1 causes acquisition of beta cell-like characteristics in a human ductal cell line.." Chem. Biol.. 2013 20 (12): 1513-1522. Pubmed PMID: 24290880
- Zhong C, Wang Y, O’Herin C, and Young DW. "Synthesis of Substituted Morpholines Using Stereodivergent Aza-Michael Reactions Catalyzed by Brønsted Acids.." ACS Catalysis. 2013 15 (6): 643-46.
Funding
- Recruitment Award
- $2,000,000.00 (03/01/2014 - 03/01/2018) Grant funding from Cancer Prevention and Research Institute of Texas
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