Email

wangj@bcm.edu

Positions

Associate Professor and CPRIT Scholar

Pharmacology and Chemical Biology
Baylor College of Medicine
Houston, Texas, United States

Associate Professor

Molecular and Cellular Biology
Baylor College of Medicine
Houston, Texas, United States

Member

Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas, United States

Member

Center for Drug Discovery
Baylor College of Medicine
Houston, Texas, United States

Addresses

BCM-Alkek Graduate School (Office)

Room: Alkek N520.05
Houston, TX 77030
United States
(713) 798-6875
wangj@bcm.edu

Education

BS from Peking University

07/2003 - Beijing, China

Chemistry

PhD from The Ohio State University

12/2007 - Columbus, Ohio, United States

Organic Chemistry

Postdoctoral Training at University of North Carolina at Chapel Hill

05/2011 - Chapel Hill, North Carolina, United States

Drug Delivery and Nanomedicine

Professional Interests

• Chemical Biology, Sensing and Imaging, Drug Discovery, and Drug Delivery

Professional Statement

The overarching goal for my research is to develop new tools to address biological questions and new therapies to improve human health, taking advantage of my unique experience in organic and medicinal chemistry, drug delivery, material sciences, cell biology and preclinical studies. My laboratory has developed the first reversible reaction-based fluorescent probe to monitor glutathione (GSH) dynamics in living cells and the first potent and safe small molecule inhibitor (SMI) for steroid receptor coactivator-3 (SRC-3) as a novel targeted cancer therapy. Additionally, we develop novel antibody-drug conjugates to target P53 defective cancer.

Websites

Selected Publications

• Jiang X, Chen J, Bajić A, Zhang C, Song X, Carroll SL, Cai ZL, Tang M, Xue M, Cheng N, Schaaf CP, Li F, MacKenzie KR, Ferreon ACM, Xia F, Wang MC, Maletić-Savatić M, Wang J "Quantitative real-time imaging of glutathione." Nature Communications. 2017 July 13; 8 : 16087. Pubmed PMID: 28703127
• Song X, Chen J, Zhao M, Zhang C, Yu Y, Lonard DM, Chow DC, Palzkill T, Xu J, O'Malley BW, Wang J. "Development of potent small-molecule inhibitors to drug the undruggable steroid receptor coactivator-3." Proc Natl Acad Sci USA. 2016 May 3; 113 (18): 4970-5. Pubmed PMID: 27084884
• "Quantitative Imaging of Glutathione in Live Cells Using a Reversible Reaction-Based Ratiometric Fluorescent Probe." ACS Chem Bio. 2015 January 6; 10 (3): 864–874. Pubmed PMID: 25531746
• "Precisely Tunable Engineering of Sub-30 nm Monodisperse Oligonucleotide Nanoparticles." J. Am. Chem. Soc.. 2014 136 (1): 234–240. Pubmed PMID: 24344996

Funding

Real-Time Quantitative Imaging of Intracellular Biothiol Dynamics - #R01GM115622

(09/22/2015 - 07/31/2021) Grant funding from NIH/NIGMS

Drugging the Undruggable Coactivators using Small Molecule Inhibitors - #R01CA207701

(03/15/2017 - 02/28/2022) Grant funding from NIH/NCI

TARGETING A LIPID-MEDIATED PRO-LONGEVITY PATHWAY AS ALZHEIMER'S THERAPY - #1RF1AG062257-01

(09/15/2018 - 06/30/2023) Grant funding from NIH/NIA

Reversible Covalent BTK Degraders As the Next Generation Targeted Therapy To Treat B-Cell Malignancies - #R01CA250503

(07/01/2020 - 06/30/2025) Grant funding from NIH/NCI

Intellectual Property

Method Patent #WO2016025382 (Pending)

Co Inventors: Xiqian Jiang; Jianwei Chen

Method Patent #WO2014078399A1 (Approved)

Co Inventors: Fude Feng

Method Patent (Pending)

Co Inventors: Bert W. O’Malley, David M. Lonard, Jianming Xu, and Jianwei Chen