Email

wangj@bcm.edu

Positions

Associate Professor and CPRIT Scholar

Pharmacology and Chemical Biology
Baylor College of Medicine
Houston, Texas United States

Associate Professor

Molecular and Cellular Biology
Baylor College of Medicine
Houston, Texas United States

Member

Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas United States

Member

Center for Drug Discovery
Baylor College of Medicine
Houston, Texas United States

Addresses

BCM-Alkek Graduate School (Office)

Room: Alkek N520.05
Houston, TX 77030
United States
(713) 798-6875
wangj@bcm.edu

Education

BS from Peking University

07/2003 - Beijing, China

Chemistry

PhD from The Ohio State University

12/2007 - Columbus, Ohio United States

Organic Chemistry

Postdoctoral Training at University of North Carolina at Chapel Hill

05/2011 - Chapel Hill, North Carolina United States

Drug Delivery and Nanomedicine

Professional Interests

• Chemical Biology, Sensing and Imaging, Drug Discovery, PROTACs, Antibody Drug Conjugates, Proteomics and Metabolomics

Professional Statement

The overarching goal for my research is to develop new tools to address biological questions and new therapies to improve human health, taking advantage of my unique experience in organic and medicinal chemistry, drug delivery, material sciences, cell biology and preclinical studies. My laboratory has developed the first reversible reaction-based fluorescent probe to monitor glutathione (GSH) dynamics in living cells and the first potent and safe small molecule inhibitor (SMI) for steroid receptor coactivator-3 (SRC-3) as a novel targeted cancer therapy. Furthermore, we recently discovered a novel strategy to enhance intracellular accumulation and target engagement for protein degraders (PROTACs). Additionally, we develop novel antibody-drug conjugates as anticancer therapeutics.

Websites

Selected Publications

• Wen-Hao Guo, Xiaoli Qi, Yang Liu, Chan-I Chung, Fang Bai, Xingcheng Lin, Lingfei Wang, Jianwei Chen, Krystle J. Nomie, Feng Li, Meng C. Wang, Xiaokun Shu, José N. Onuchic, Jennifer A. Woyach, Michael L. Wang, Jin Wang* "Enhancing intracellular accumulation and target engagement of PROTACs with reversible covalent chemistry." Nature Communications. 2020 11 : 4268. Pubmed PMID: 32848159
• Jiang X, Chen J, Bajić A, Zhang C, Song X, Carroll SL, Cai ZL, Tang M, Xue M, Cheng N, Schaaf CP, Li F, MacKenzie KR, Ferreon ACM, Xia F, Wang MC, Maletić-Savatić M, Wang J "Quantitative real-time imaging of glutathione." Nature Communications. 2017 July 13; 8 : 16087. Pubmed PMID: 28703127
• Song X, Chen J, Zhao M, Zhang C, Yu Y, Lonard DM, Chow DC, Palzkill T, Xu J, O'Malley BW, Wang J. "Development of potent small-molecule inhibitors to drug the undruggable steroid receptor coactivator-3." Proc Natl Acad Sci USA. 2016 May 3; 113 (18): 4970-5. Pubmed PMID: 27084884
• "Quantitative Imaging of Glutathione in Live Cells Using a Reversible Reaction-Based Ratiometric Fluorescent Probe." ACS Chem Bio. 2015 January 6; 10 (3): 864–874. Pubmed PMID: 25531746

Funding

Developing Novel Soluble Epoxide Hydrolase Inhibitors for the Treatment of Alzheimer's Disease - #U01AG068031

(09/15/2020 - 05/31/2025) Grant funding from NIH/NIA

Reversible Covalent BTK Degraders As the Next Generation Targeted Therapy To Treat B-Cell Malignancies - #R01CA250503

(07/01/2020 - 06/30/2025) Grant funding from NIH/NCI

TARGETING A LIPID-MEDIATED PRO-LONGEVITY PATHWAY AS ALZHEIMER'S THERAPY - #RF1AG062257

(09/15/2018 - 06/30/2023) Grant funding from NIH/NIA

Drugging the Undruggable Coactivators using Small Molecule Inhibitors - #R01CA207701

(03/15/2017 - 02/28/2022) Grant funding from NIH/NCI

Intellectual Property

Method Patent #WO2016025382 (Pending)

Co Inventors: Xiqian Jiang; Jianwei Chen

Method Patent #WO2014078399A1 (Approved)

Co Inventors: Fude Feng

Method Patent #WO2017176981A1 (Approved)

Co Inventors: Bert W. O’Malley, David M. Lonard, Jianming Xu, and Jianwei Chen

Method Patent (Pending)

Co Inventors: Jin Wang, Wen-Hao Guo, Xiaoli Qi, Michael Wang, Krystle Nomie, and Yang Yu