Positions
- Associate Professor
-
Department of Pathology & Immunology Center for Drug Discovery
Baylor College of Medicine
Houston, TX US
- Associate Professor
-
Department of Pharmacology and Chemical Biology
Baylor College of Medicine
Professional Interests
- LC-MS-based metabolomics
- Drug metabolism and pharmacokinetics
- Drug-induced liver injury
- Blood testis barrrier
Websites
Selected Publications
- Kevin R MacKenzie, Mingkun Zhao, Mercedes Barzi, Jin Wang, Karl-Dimiter Bissig, Mirjana Maletic-Savatic, Sung Yun Jung , Feng Li* "Metabolic profiling of norepinephrine reuptake inhibitor atomoxetine." Eur J Pharm Sci.. 2020;153:105488. Pubmed PMID: 32712217
- Feng Li*, Kevin R MacKenzie, Prashi Jain, Conrad Santini, Damian W Young , Martin M Matzuk "Metabolism of JQ1, an inhibitor of bromodomain and extra terminal bromodomain proteins, in human and mouse liver microsomes." Biol Reprod. 2020;103:427-436. Pubmed PMID: 32285106
- Feng Li, Jie Lu, Xiaochao Ma "Profiling the reactive metabolites of xenobiotics using metabolomic technologies." Chem. Res. Toxicol.. 2011;24:744-751. Pubmed PMID: 21469730
- Xing Liu, Yuanfu Lu, Xinfu Guan, Bingning Dong, Hemantkumar Chavan, Jin Wang, Yiqing Zhang, Partha Krishnamurthy, Feng Li* "Metabolomics reveals the formation of aldehydes and iminium in gefitinib metabolism." Biochem Pharmacol.. 2015 Sep 1;97(1):111-121. Pubmed PMID: 26212543
- Feng Li, Jie Lu, Jie Cheng, Laiyou Wang, Tsutomu Matsubara, Ivan Csanaky, Curtis D. Klaassen, Frank J. Gonzalez, Xiaochao Ma "Human PXR modulates hepatotoxicity associated with rifampicin and isoniazid co-therapy." Nat. Med.. 2013;19:418-420. Pubmed PMID: 23475203
- Xing Liu, Yuan-Fu Lu, Xinfu Guan, Mingkun Zhao, Jin Wang, Feng Li* "Characterizing novel metabolic pathways of melatonin receptors agonist agomelatine using metabolomics approaches." Biochem Pharmacol.. 2016 Jun 1;109:70-82. Pubmed PMID: 27021842
- Xuan Qin, John M Hakenjos, Kevin R MacKenzie, Mercedes Barzi, Hemantkumar Chavan, Pranavanand Nyshadham, Jin Wang, Sung Yun Jung, Joie Z Guner, Si Chen, Lei Guo, Partha Krishnamurthy, Karl-Dimiter Bissig, Stephen Palmer, Martin M Matzuk, Feng Li* "Metabolism of a Selective Serotonin and Norepinephrine Reuptake Inhibitor Duloxetine in Liver Microsomes and Mice." Drug Metab Dispos. 2022;50:128-139.
- Michelle L Spruill, Mirjana Maletic-Savatic, Howard Martin, Feng Li*, Xinli Liu* "Spatial analysis of drug absorption, distribution, metabolism, and toxicology using mass spectrometry imaging." Biochem Pharmacol. 2022;201:115080.
Funding
- Mechanisms of Liver Toxicity of Anti-Depressant Duloxetine - #R01DK121970 Grant funding from NIH/NIDDK
- Elucidating Chemical Features that Block or Facilitate Passage across the BloodTestis and/or Blood-Epidydimal Barriers in Mice - #R61HD099995 Grant funding from NIH/NICHD
- Elucidating Chemical Features that Block or Facilitate Passage across the BloodTestis and/or Blood-Epidydimal Barriers in Mice - #R33HD099995 Grant funding from NIH/NICHD
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