Zhi Tan, M.D., Ph.D.

Assistant Professor

Email

zhi.tan@bcm.edu

Positions

Assistant Professor: Pathology
Baylor College of Medicine
Houston, US

Assistant Professor: Center for Drug Discovery
Baylor College of Medicine

Assistant Professor: Pharmacology and Chemical Biology
Baylor College of Medicine

Addresses

Jan and Dan Duncan Neurological Research Institute Building - 6th Floor (Office): Houston, TX, 77030
United States

Education

MD from Wuhan University: 06/2012 - Wuhan, Hubei, China

PhD from University of Texas MD Anderson and UT Health Graduate School of Biomedical Science: 12/2018 - Houston, Texas, United States

Websites

Zhi Tan Lab

Selected Publications

Yajuan Li*, Zhi Tan*, Yaohua Zhang*, et al. (*Equal Contribution). " A noncoding RNA modulator potentiates phenylalanine metabolism in mice " Science. 2021 Aug ;
Ram K Modukuri*, Zhifeng Yu*, Zhi Tan*, Hai Minh Ta*, et al. (*Equal contribution). " Discovery of potent BET bromodomain 1 stereoselective inhibitors using DNA-encoded chemical library selections " PNAS. 2022 May ;
Peiwen Chen, Wen-Hao Hsu, Andrew Chang, Zhi Tan, Zhengdao Lan, Ashley Zhou, Denise J Spring, Frederick F Lang, Y Alan Wang, Ronald A DePinho. " Circadian Regulator CLOCK Recruits Immune-Suppressive Microglia into the GBM Tumor MicroenvironmentCLOCK in Tumor Immunity " Cancer Discovery. 2020 Mar ;
Jacqulyne P Robichaux, Yasir Y Elamin, Zhi Tan, et al.. " Mechanisms and clinical activity of an EGFR and HER2 exon 20–selective kinase inhibitor in non–small cell lung cancer " Nature Medicine. 2018 May ;
Mingxing Teng, Damian W Young, Zhi Tan. " The Pursuit of Enzyme Activation: A Snapshot of the Gold Rush " Jounal of Medicinal Chemistry. 2022 Oct ;
Baoli Hu, Qianghu Wang, Y Alan Wang, Sujun Hua, Charles-Etienne Gabriel Sauvé, Derrick Ong, Zheng D Lan, Qing Chang, Yan Wing Ho, Marta Moreno Monasterio, Xin Lu, Yi Zhong, Jianhua Zhang, Pingna Deng, Zhi Tan, et al.. " Epigenetic activation of WNT5A drives glioblastoma stem cell differentiation and invasive growth " Cell. 2016 Nov ;
Chengcao Sun*, Youqiong Ye* , Zhi Tan*, et al. (* Equal Contribution). " Tumor-associated nonmyelinating Schwann cell–expressed PVT1 promotes pancreatic cancer kynurenine pathway and tumor immune exclusion " Science advance. 2023 Jan ;
Pubmed PMID: 36724291.
Zhi Tan, Thomas Garcia.. " SLO3 in the fast lane: The latest male contraceptive target with a promising small-molecule inhibitor " PNAS. 2023 Feb ;
Pubmed PMID: 36791103.

Funding

First Time Tenture Track Faculty Award #RR220039: $2,000,000.00 (06/01/2022 - 06/01/2027); Grant funding from CPRIT