A pulmonary embolism, or PE, is a blood clot that develops in a blood vessel elsewhere in the body (most commonly from the leg), travels to the lung, and forms an occlusion of a blood vessel in the lung. This blood vessel occlusion, due to a blood clot which travels from one area of the body to another area, is called an embolism. An embolism to the lung, or pulmonary embolism, may cause serious life-threatening consequences and, potentially, death. Most commonly, a PE is the result of a condition called deep vein thrombosis (blood clot in the deep veins of the leg).
Blood clotting is a normal process that occurs in the body to prevent bleeding. The body makes blood clots and then breaks them down. Under certain circumstances, the body may be unable to break down a clot, which may result in a serious health condition. Blood clots can form in arteries and/or veins. Clots formed in veins are called venous clots. Veins of the legs can be classified as superficial veins (close to the surface of the skin) or deep veins (located near the bone and surrounded by muscle).
Venous clots most often occur in the deep veins of the legs. This condition is called deep vein thrombosis (DVT), or deep vein clot. Once a clot has formed in the deep veins of the leg, there is a potential for part of the clot to break off and travel (embolize) through the bloodstream to another area of the body. Deep vein thrombosis is the most common cause of a pulmonary embolism. Therefore, the term venous thromboembolism (VTE) may refer to deep vein thrombosis and/or the complication, pulmonary embolism.
Other less frequent sources of pulmonary embolism are a fat embolus, amniotic fluid embolus, air bubbles, and a deep vein thrombosis in the upper body. Clots may also form on the end of an indwelling intravenous (IV) catheter, break off, and travel to the lungs.
A risk factor is anything that may increase a person's chance of developing a disease. It may be an activity, such as smoking, diet, family history, or many other things. Different diseases have different risk factors.
Although these risk factors increase a person's risk, they do not necessarily cause the disease. Some people with one or more risk factors never develop the disease, while others develop disease and have no known risk factors. Knowing your risk factors to any disease can help to guide you into the appropriate actions, including changing behaviors and being clinically monitored for the disease.
There are several risk factors that are associated with the processes that may increase the risk of a venous thromboembolism, which include certain medical conditions, such as heart failure, chronic obstructive pulmonary disease (COPD), hypertension (high blood pressure), stroke, and inflammatory bowel disease (chronic inflammation of the digestive tract). Other risk factors are:
- Genetic conditions that increase the risk of blood clot formation
- Surgery or trauma (especially to the legs) or orthopedic surgery
- Situations in which mobility is limited, such as extended bed rest, flying or riding long distances, or paralysis
- Previous history of clots
- Older age
- Cancer and cancer therapy
- Certain medications, such as oral contraceptives (birth control pills) and hormone replacement therapy (estrogen pills for postmenopausal women)
- Pregnancy (during and after pregnancy, including cesarean section)
- Varicose veins (enlarged veins in the legs)
- Cigarette smoking
The type and extent of symptoms of a pulmonary embolism will depend on the size of the embolism and whether the person already has existing heart and/or lung problems. You may or may not have these symptoms should a pulmonary embolism occur. Usually, if a PE is suspected, the physician will check your legs for evidence of a deep vein thrombosis. The symptoms of a pulmonary embolism may resemble other medical conditions or problems. Always consult your physician for a diagnosis.
The following are the most common symptoms for pulmonary embolism. However, each individual may experience symptoms differently:
- Sudden shortness of breath (most common)
- Chest pain (usually worse with breathing)
- Dizziness, lightheadedness, or fainting
- Palpitations (heart racing)
- Coughing up blood (hemoptysis)
- Low blood pressure
- Symptoms of deep vein thrombosis, such as pain in the affected leg (may occur only when standing or walking), swelling in the leg, soreness, tenderness, redness, and/or warmth in the leg(s), or redness and/or discolored skin
Pulmonary embolism is often difficult to diagnose because the signs and symptoms of PE mimic those of many other conditions and diseases. In addition to a complete medical history and physical examination, diagnostic procedures for a pulmonary embolism may include any, or a combination, of the following:
Chest x-ray. A type of diagnostic radiology procedure used to assess the lungs, as well as the heart. Chest x-rays may provide important information regarding the size, shape, contour, and anatomic location of the heart, lungs, bronchi, great vessels (aorta and pulmonary arteries), and mediastinum (area in the middle of the chest separating the lungs).
Ventilation-perfusion scan (V/Q scan). A type of nuclear radiology procedure in which a tiny amount of a radioactive substance is used during the procedure to assist in the examination of the lungs. A ventilation scan evaluates ventilation, or the movement of air into and out of the bronchi and bronchioles. A perfusion scan evaluates blood flow within the lungs.
Pulmonary angiogram. An x-ray image of the blood vessels used to evaluate various conditions, such as aneurysm, stenosis (narrowing of the blood vessel), or blockages. A dye (contrast) will be injected through a thin flexible tube placed in an artery. This dye makes the blood vessels visible on x-ray.
Spiral computed tomography (also called CT or CAT scan). A diagnostic procedure that uses a combination of x-rays and computer technology to produce cross-sectional images (often called slices). CT with contrast enhances the image of the blood vessels in the lungs. Contrast refers to a substance injected into an intravenous (IV) line that causes the particular organ or tissue under study to be seen more clearly.
Magnetic resonance imaging (MRI). A diagnostic procedure that uses a combination of large magnets, radiofrequencies, and a computer to produce detailed images of organs and structures within the body.
Duplex ultrasound. A type of vascular ultrasound procedure done to assess blood flow and the structure of the blood vessels in the lungs. The term "duplex" refers to the fact that two modes of ultrasound are used. Doppler and B-mode. The B-mode transducer (like a microphone) obtains an image of the vessel being studied. The Doppler probe within the transducer evaluates the velocity and direction of blood flow in the vessel.
Laboratory tests. Blood tests to check the blood's clotting status. Other blood work may include testing for genetic (inherited) disorders that may contribute to abnormal clotting of the blood. In addition, arterial blood gases may be checked to determine the amount of oxygen in the blood.
Electrocardiogram (ECG or EKG). One of the simplest and fastest procedures used to evaluate the heart. Electrodes (small, plastic patches) are placed at certain locations on the chest, arms and legs. When the electrodes are connected to an ECG machine by lead wires, the electrical activity of the heart is measured, interpreted and printed out for the physician's information and further interpretation.
Specific treatment will be determined by your physician based on:
- Age, overall health, and medical history
- Extent of the disease
- Signs and symptoms
- Tolerance for specific medications, procedures, or therapies
- Expectations for the course of the disease
- Your opinion or preference
Treatment options include:
Anticoagulants. Also described as "blood thinners," these medications decrease the ability of the blood to clot. Examples of anticoagulants include warfarin (Coumadin®) and heparin.
Vena cava filter. A small metal device placed in the vena cava (the large blood vessel that returns blood from the body to the heart) may be used to prevent clots from traveling to the lung. These filters are generally used in patients who cannot receive anticoagulation treatment (for medical reasons), who develop additional clots even with anticoagulation treatment, or who develop bleeding complications from anticoagulation.
Thrombolytic therapy. A small catheter is inserted in the leg vein in which special thrombolytic medication or "clot buster drug" is delivered directly to the clot in the lung. These medications will break down the clot in the lung.
Percutaneous thrombectomy. A special clot removal device is inserted, using x-ray guidance, to the lung so that clot in the lung can be removed or extracted using the clot removal device.