The shared resources of the Dan L Duncan Comprehensive Cancer Center provide extensive services essential to cancer research. As an NCI-designated center, our Cancer Center Support Grant allows us to fund advanced technologies, equipment, data analysis and biostatistics and informatics services that would be difficult and expensive for individual investigators or programs to develop and maintain on their own. The Duncan Cancer Center fully funds four shared resources and partially funds seven matrix resources which are resources that also receive support from other grants and are available to all investigators at Baylor College of Medicine.
Duncan Cancer Center Cores
The following cores are shared resources primarily funded through the Duncan Cancer Center. They facilitate cancer-focused research for members of the center.
Biostatistics and Informatics
The Biostatistics and Informatics shared resource supports the research efforts of Duncan Cancer Center investigators through collaboration on biostatistical and informatic aspects of design, conduct, analysis, and interpretation of clinical, translational and basic science studies.
Learn more about Biostatistics and Informatics.
Director: Susan Hilsenbeck, Ph.D.
Phone: (713) 798-1632
Co-Director (Biostatistics): Hao Liu, Ph.D.
Phone: (713) 798-5586
Co-Director (Cancer Bioinformatics): Chad Creighton, Ph.D.
Phone: (713) 798-2264
Co-Director (Multi-Omic Bioinformatics): Cristian Coarfa, Ph.D.
Phone: (713) 798-7938
Co-Director (Data Sharing): Neil McKenna, Ph.D.
Phone: (713) 798-8568
Cell Processing and Vector Production
The Cell Processing and Vector Production shared resource provides GMP manufacturing of therapeutic grade cellular products and viral and non-viral vectors for use in early phase clinical trials and to facilitate the preparation of the associated regulatory documentation.
Learn more about Cell Processing and Vector Production.
Director: Adrian Gee, Ph.D.
Phone: (832) 824-4675
CPRIT Cancer Proteomics and Metabolomics
Additional services are available through CPRIT Cancer Proteomics and Metabolomics - a group funded through a grant from the Cancer Prevention Research Institute of Texas.
Matrix cores are shared resources with funding from multiple sources including the Duncan Cancer Center and Baylor. They are available to all faculty as institutional Advanced Technology Cores.
The Antibody-Based Proteomics shared resource provides highly customized services to Baylor and the Texas Medical Center community for protein profiling and affinity based proteomic platforms. Services include Luminex bead technology for multiplex quantitative analyses of intracellular and extracellular proteins and various signaling pathways; antibody and protein-protein interaction arrays as discovery tools for protein biomarkers, and construction of monoclonal antibody producing B-cell hybridomas and recombinant baculoviruses for expression of proteins in insect cells.
Learn more about Antibody-Based Proteomics.
Learn more about Monoclonal Antibody/Recombinant Protein Expression.
Director: Dean P. Edwards, Ph.D.
Phone: (713) 798-2326
Co-director: Shixia Huang, Ph.D.
Phone: (713) 798-8722
Cell-Based Assay Screening
The Cell-Based Assay Screening shared resource facilitates Duncan Cancer Center investigators in their use of new RNAi technologies and genetic screening methods, as well as cutting-edge technology to probe important mechanistic questions in basic and translational cancer biology.
Director: Trey Westbrook, Ph.D.
Co-Director: Dan Liu, Ph.D.
Phone: (713) 798-8032
Cytometry and Cell Sorting
With the advent of novel fluorescent assays and reagents, increased computational capacity and cost-effective optical equipment, the cytometry and cell sorting shared resource enables cutting-edge cancer research by providing state-of-the-art instrumentation, exceptional expertise and training to Duncan Cancer Center members.
Director: Christine Beeton, Ph.D.
Co-Director: Joel M. Sederstrom, M.B.S.
Phone: (713) 798-3868
Genetically Engineered Mouse
The Genetically Engineered Mouse shared resource aids Duncan Cancer Center investigators with the design and execution of experiments, to utilize animal models for the investigation of the progression of cancer, and to conduct preclinical evaluation of therapies for the treatment of cancer.
Director: Jianming Xu, Ph.D. (GEM)
Phone: (713) 798-6199
Co-Director: Jason D. Heaney, Ph.D. (ES Cell)
Phone: (713) 798-1778
Genomic and RNA Profiling
The Genomic and RNA Profiling shared resource provides Duncan Cancer Center investigators access to state-of-the-art quality molecular profiling technology services for both transcriptional and genomic profiling, including microarray and next generation sequencing. We assist researchers in utilizing genomic profiling technology employing good experimental design, and providing data management and data analysis resources.
Director: Lisa White, Ph.D.
Phone: (713) 798-7699
Human Tissue Acquisition and Pathology
The Human Tissue Acquisition and Pathology shared resource offers comprehensive pathology support to Duncan Cancer Center members. Services include: Histology and pathology, immunohistochemistry and TUNEL assay, laser capture, image analysis, pathology consultation, tissue microarray development, and tissue acquisition and distribution.
Director: Michael Ittmann, M.D., Ph.D.
Phone: (713) 798-3705
The Integrated Microscopy shared resource provides state-of-the-art light and electron microscopic imaging, image analysis resources, and cellular-image-based assay development assistance to researchers in the Duncan Cancer Center.
Director: Michael Mancini, Ph.D.
Phone: (713) 798-8952
Co-Director: Fabio Stossi, Ph.D.
Phone: (713) 798-6940
Mass Spectrometry Proteomics
The Mass Spectrometry Proteomics Core features state-of-the-art Thermo Scientific Orbitrap and AB Sciex 5600 instrumentation and offers comprehensive service packages for proteome-wide label free quantitative proteomic profiling of cells and tissues, isolation and identification of protein complexes via immunoprecipitation followed by mass spectrometry, post-translational modification analysis, and routine protein identification from purified samples. The services are provided with the full support that includes project evaluation and design, biochemical purifications, mass spectrometry sequencing, and data analysis performed within the core by experienced core personnel. For details, please visit Mass Spectrometry Proteomics website and check the DLDCCC service rates.
Academic Director: Anna Malovannaya, Ph.D.
Core Directors: Sung Yun Jung, Ph.D.; Hon-Chiu Eastwood Leung, Ph.D.
The newly established Cancer Metabolomics shared resource at Baylor is an analytical facility specializing in liquid chromatography hyphenated with mass spectrometry funded by both the Alkek Center for Molecular Discovery and the Cancer Prevention Research Institute of Texas, which has established the infrastructure to study metabolites. Our main role is to support investigators in their research in the study of metabolism in cancer as well as the understanding of the mechanisms of particular cancer states which will ideally lead to earlier detection and better treatments.
Director: Arun Sreekumar, Ph.D.
Co-Director: Nagireddy Putluri, Ph.D.
Patient-Derived Xenograft and Advanced In Vivo Models Core
The Patient-Derived Xenograft and Advanced In Vivo Models Core of Baylor College of Medicine is divided into two independent but closely interacting functional units, a PDX Development Unit created to facilitate establishment and use of PDX using immunocompromised mice as the host species, and an Advanced In Vivo Models Unit created to facilitate establishment and use of patient material grown on the chorioallantoic membrane of the chicken egg (CAM-PDX). The Advanced In Vivo Models Unit will also provide services to establish 3-D tumors from existing cancer cell lines, and creation and optimization of custom bioassays.
Learn more about Patient-Derived Xenograft and Advanced In Vivo Models Core.
PDX Development Unit:
Academic Director: Michael Lewis, Ph.D.
Core Director: Lacey Dobrolecki, MT, MS
Phone: (713) 798-1538
Advanced In Vivo Models Unit:
Academic Director: Andrew Sikora, M.D., Ph.D.
Core Director: Ravi Pathak, Ph.D., M.B.A.
Phone: (713) 798-0118
Population Sciences Biorepository
The Population Sciences Biorepository supports a high-quality molecular epidemiology program in the Duncan Cancer Center and at Baylor College of Medicine. We provide necessary risk factor and clinical data collection and a centralized, cost-effective facility for biospecimen processing and storage of biospecimens from large epidemiological and clinical studies.
Director: Michael Scheurer, Ph.D.
Instructions for Acknowledgement of Cancer Center Support Grant in Publications
Be sure to cite the NCI Cancer Center Support Grant (P30CA125123) and acknowledge the support of Shared Resources on all cancer relevant publications. Please acknowledge the specific Shared Resource(s) used by its appropriate name.
This is important documentation for renewal of the Duncan Cancer Center grant and continued funding of Shared Resources.