With the high rate of use of antimicrobial drugs throughout the world, the emergence and spread of drug-resistant pathogens is a major threat to long-term infection control.  An increased understanding of pathogen evasion and persistence mechanisms as well as advances in immunology and host-microbe interactions have provided a foundation for new therapeutic targets and approaches to eradicate or control infections.

Our research in the Antibiotics, Antivirals, and Drug Resistance research area: seeks to answer fundamental questions about the evolution and mechanisms of drug resistance; develop new antimicrobial drugs; engineer gene and immune based-therapies; and develop microbial-based therapeutics.

Our group takes full advantage of the rich facilities in the College, each filled with state-of-the-art equipment and expertise, including the Human Genome Sequencing Center, the Alkek Center for Metagenomics and Microbiome Research, the Center for Drug Discovery, the Alkek Center for Molecular Discovery (including their Metabolomics Core), the Center for Cell and Gene Therapy, and the Cryo-Electron Microscopy Core.

Profiles of Faculty Working on Antibiotics, Antivirals and Drug Resistance

Robert Allen Britton, Ph.D.

Professor

Therapeutic microbiology, probiotics, genomics and genetics of the human microbiota

Brian Edward Gilbert, Ph.D.

Associate Professor

Phone

  • (713) 798-4022

Aerosolized drugs for pulmonary diseases

Joseph Michael Hyser, Ph.D.

Assistant Professor

Phone

  • (713) 798-4514

Enteric Virus Calcium Channel Blockers; Exploitation of Host Calcium Signaling Pathways by Microbes…

Jason Thomas Kimata, PH.D.

Associate Professor

Phone

  • (713) 798-4536

HIV Replication, Pathogenesis, and Cure

Katherine Yudeh King, M.D., Ph.D.

Associate Professor

Role of interferon-gamma in hematopoietic stem cell regulation

Ann Marie Leen, Ph.D.

Assistant Professor

Phone

  • (832) 824-4690

T cell immunotherapy for viruses and cancer

Anthony Maresso, Ph.D.

Associate Professor

Phone

  • (713) 798-7369

Pathogenesis of bacterial infections

Timothy Gerald Palzkill, Ph.D.

Chair/Professor

Phone

  • (713) 798-5609

Protein structure/function and functional genomics; Enzymology; Structural Biology; Membrane Proteins; Drug Resistance Mechanisms…

Pedro A. Piedra, M.D.

Professor

Phone

  • (713) 798-5240

Reduction of respiratory virus illness burden in infants

Robert Franklin Ramig, Ph.D.

Professor

Phone

  • (713) 798-4830

Phage Therapy for Human Infections; Genetics of viral replication and pathogenesis

Andrew Patrick Rice, Ph.D.

Professor

Phone

  • (713) 798-5774

Viral gene expression

Buck Samuel, Ph.D.

Assistant Professor

Phone

  • (713) 798-9110

Genetics and genomics of host-microbe interactions; Microbiome programming of host physiology and development…

Francis T.F. Tsai, D.Phil.

Professor

Phone

  • (713) 798-8668

Protein Structure-Function and Protein Folding; Structural Biology and Macromolecular Assemblies; Cryo-electron Microscopy and Tomography…

E. Lynn Zechiedrich, Ph.D.

Kyle and Josephine Morrow Chair in Molecular Virology and Microbiology

Phone

  • (713) 798-5126

DNA supercoiling, DNA topoisomerases, antibiotic resistance, gene therapy