Email

joseph.hyser@bcm.edu

Positions

Associate Professor

Virology & Microbiology
Baylor College of Medicine
Houston, TX, US

Member

Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas, United States

Addresses

BCM-Jewish Wing (Lab)

Room: BCM-824D
Houston, TX, 77030
United States
Phone: (713) 798-4514
joseph.hyser@bcm.edu

Education

Post-doctoral Training from Baylor College Of Medicine

01/2010 - Houston, TX, United States

Viroporins, Rotavirus

Ph.D. from Baylor College Of Medicine

01/2007 - Houston, TX, United States

BA from Augustana College

05/1999 - Rock Island, IL, United States

Biology, Philosophy

Professional Interests

• Enteric Virus Calcium Channel Blockers
• Exploitation of Host Calcium Signaling Pathways by Microbes
• Characterization of Viral Ion Channels (Viroporins)
• Engineering of human intestinal enteroids

Websites

Selected Publications

• 17. J.L. Perry, N.K. Ramachandran, B. Utama, and J.M. Hyser. " Use of Genetically-encoded Calcium Indicators for Live Cell Calcium Imaging and Localization in Virus-infected Cells " Methods. 2015 Nov 15; 15 (90)
  Pubmed PMID: 26344758.
• Hyser JM, Utama B, Crawford SE, Broughman JR, Estes MK.. " Activation of the endoplasmic reticulum calcium sensor STIM1 and store-operated calcium entry by rotavirus requires NSP4 viroporin activity " J. Virol.. 2013 ; 87 (4) : 13579-88.
  Pubmed PMID: 24109210.
• 22. A.C. Strtak, J.L. Perry, M.N. Sharp, A.L. Chang-Graham, T. Farkas, J.M. Hyser. " Recovirus NS1-2 has viroporin activity that induces aberrant cellular calcium signaling to facilitate virus replication " mSphere. 2019 Sep 18; 4 (5)
  Pubmed PMID: 31533997.
• 21. A.L. Chang-Graham, J.L. Perry, A.C. Strtak, N.K. Ramachandran, J.M. Criglar, A.A. Philip, J.T. Patton, M.K. Estes, and J.M. Hyser. " Rotavirus calcium dysregulation manifests as dynamic calcium signaling in the cytoplasm and endoplasmic reticulum " Sci Rep. 2019 Jul 25; 9 (1)
  Pubmed PMID: 31346185.
• Hyser JM, Collinson-Pautz MR, Utama B, Estes MK. " Rotavirus Disrupts Calcium Homeostasis by NSP4 Viroporin Activity. " MBio. 2010 ; 1 (5)
  Pubmed PMID: 21151776.
• 33. A.L. Chang-Graham, J.L. Perry, M.A. Engevik, K.A. Engevik, F.J. Scribano, J.T. Gebert, H.A. Danhof, J.C. Nelson, J.S. Kellen, A.C. Strtak, N.P. Sastri, M.K. Estes, R.A. Britton, J. Versalovic, J.M. Hyser. " Rotavirus induces intercellular calcium waves through ADP signaling " Science. 2020 Nov 20; 370 : eabc3621.
  Pubmed PMID: 33214249.

Show 2 more publications

Memberships

American Society for Virology

American Society for Microbiology

American Physiology Society

American Gastroenterological Association