The immune system develops from hematopoietic stem and progenitor cells in the bone marrow, which undergo extensive genetic and epigenetic reprogramming to differentiate into mature immune cells. Understanding the generation and function of mature immune cells throughout life in both normal and disease states may lead to novel therapeutic strategies for immunodeficiency, autoimmune conditions, and infectious diseases.
Faculty and students in our program study all aspects of the development, metabolism, and function of dendritic cells, T, B and NK lymphocytes, and monocytes/macrophages in human samples and in animal models.
This research is supported by state of the art Advanced Technology Cores.
Profiles of Faculty Working on Immune System Development, Metabolism and Function
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