Positions
- Assistant Professor
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Medicine
Immunology, Allergy and Rheumatology
Baylor College of Medicine
Houston, TX US
- Graduate Faculty Member
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Immunology and Microbiology
Baylor College of Medicine
- Graduate Faculty Member
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Development, Disease Models and Therapeutics
Baylor College of Medicine
Addresses
- Main Office (Office)
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Baylor College of Medicine
Room: N903.02 Alkek
Houston, TX 77030
United States
(713) 798-2664
Education
- PhD from University of Texas Southwestern Medical Center
- Houston, Texas United States
- Embryonic Development, Programmed Cell Death
- Postdoctoral Fellowship at Wellcome Trust Sanger Institute
- Cambridge, United Kingdom
- microRNAs, Immunology
Professional Interests
- Role of Let-7 in COPD and asthma
- Omics-miRNA regulatory networks
- let-7 in inflammatory diseases of the lung
Professional Statement
We are interested in the cellular and molecular pathways of microRNAs in inflammatory diseases. Our approach is multipronged and we work with genetically modified mice and clinical samples to decipher the mechanism of action of microRNAs. We have undertaken projects to delineate the function of miRNAs involved in adaptive and/or innate immunity (i.e. miR-155, miR-22), heart failure (i.e. miR-22), and lung COPD (i.e. miR-22). Currently, my research group, is dedicated to discovering the let-7 microRNA regulatory networks (targetomics) that contribute to chronic lung inflammatory disease(s). Our most recent work is exploring how the miRNA let-7 family functions in immune cells and lung stem cells to influence inflammation and lung injury in murine models of COPD and respiratory virus infection. A more recent funded project seeks to understand the role of let-7 as a direct regulator of IL6 and IL10 utilizing novel genetically modified mice. Our combined work highlights the importance of miRNAs in a wide-range human diseases and have potential implications in miRNA-based therapeutics.Selected Publications
- Nam JW, Rissland OS, Koppstein D, Abreu-Goodger C, Jan CH, Agarwal V, Yildirim MA, Rodriguez A, Bartel DP "Global analyses of the effect of different cellular contexts on microRNA targeting." Mol Cell. 2014 March 20; : Pubmed PMID: 24631284
- Gurha P, Wang T, Larimore AH, Sassi Y, Abreu-Goodger C, Ramirez MO, Reddy AK, Engelhardt S, Taffet GE, Wehrens XH, Entman ML, Rodriguez A "microRNA-22 promotes heart failure through coordinate suppression of PPAR/ERR-nuclear hormone receptor transcription." PLoS One. 2013 : Pubmed PMID: 24086656
- Gurha P, Abreu-Goodger C, Wang T, Ramirez MO, Drumond AL, van Dongen S, Chen Y, Bartonicek N, Enright AJ, Lee B, Kelm RJ, Reddy AK, Taffet GE, Bradley A, Wehrens XH, Entman ML, Rodriguez A "Targeted deletion of microRNA-22 promotes stress-induced cardiac dilation and contractile dysfunction." Circulation. 2012 June 5; : Pubmed PMID: 22570371
- Lu W, You R, Yuan X, Yang T, Samuel EL, Marcano DC, Sikkema WK, Tour JM, Rodriguez A, Kheradmand F, Corry DB "The microRNA miR-22 inhibits the histone deacetylase HDAC4 to promote T(H)17 cell-dependent emphysema." Nat Immunol. 2015 November ; : Pubmed PMID: 26437241
- Rodriguez A, Vigorito E, Clare S, Warren MV, Couttet P, Soond DR, van Dongen S, Grocock RJ, Das PP, Miska EA, Vetrie D, Okkenhaug K, Enright AJ, Dougan G, Turner M, Bradley A "Requirement of bic/microRNA-155 for normal immune function." Science. 2007 April 27; : Pubmed PMID: 17463290
- Vigorito E, Perks KL, Abreu-Goodger C, Bunting S, Xiang Z, Kohlhaas S, Das PP, Miska EA, Rodriguez A, Bradley A, Smith KG, Rada C, Enright AJ, Toellner KM, Maclennan IC, Turner M "microRNA-155 regulates the generation of immunoglobulin class-switched plasma cells.." Immunity. 2007 December ; : Pubmed PMID: 18055230
- Kadmon CS, Landers CT, Li HS, Watowich SS, Rodriguez A, King KY "MicroRNA-22 controls interferon alpha production and erythroid maturation in response to infectious stress in mice." Exp Hematol. 2017 September 11; : Pubmed PMID: 28911907
- Robinton DA, Chal J, Lummertz da Rocha E, Han A, Yermalovich AV, Oginuma M, Schlaeger TM, Sousa P, Rodriguez A, Urbach A, Pourquié O, Daley GQ "The Lin28/let-7 Pathway Regulates the Mammalian Caudal Body Axis Elongation Program." Dev Cell. 2019 January 17; : Pubmed PMID: 30661985
- Rowe RG, Wang LD, Coma S, Han A, Mathieu R, Pearson DS, Ross S, Sousa P, Nguyen PT, Rodriguez A, Wagers AJ, Daley GQ "Developmental regulation of myeloerythroid progenitor function by the Lin28b-let-7-Hmga2 axis." J Exp Med. 2016 July 25; : Pubmed PMID: 27401346
- Rodriguez A, Griffiths-Jones S, Ashurst JL, Bradley A "Identification of mammalian microRNA host genes and transcription units." Genome Research. 2004 October ; : Pubmed PMID: 15364901
- Long J, Badal SS, Wang Y, Chang BH, Rodriguez A, Danesh FR "MicroRNA-22 is a master regulator of bone morphogenetic protein-7/6 homeostasis in the kidney." J Biol Chem. 2013 December 20; : Pubmed PMID: 24163368
Funding
- Mechanism and Function of let-7, a Novel Modulator of Emphysema - #1R01HL140398-01A1 (09/01/2018 - 08/31/2023) Grant funding from NIH (NHLBI)
- PI
- Role of let-7 as a Genetic Modifier of Alzheimer's Disease - #3R01HL140398-02S1 (09/19/2019 Grant funding from NIH (NIA)
- PI
- Molecular and Cellular Dissection of miRNAs in Controlling Allergic Airway Inflammation in Mice - #1 I01 BX004828-01A1 Grant funding from VA CSRandD Merit
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