Research

Congenital Developmental Heart Disease

Master
Heading

Theme Leaders

Content

Mary Dickinson, Ph.D.
Professor, Molecular Physiology
Research Interest - Role of fluid-derived mechanical forces in vascular remodeling and heart morphogenesis

Daniel Penny, M.D., Ph.D., MHA
Professor, Pediatrics-Cardiology
Research Interest - Cardiovascular hemodynamics in children with congenital heart disease

Heading

Current Clinical Projects

Content

A focus of our clinical research this past year has been participation in the NHLBI Pediatric Heart Network (Penny, Andropoulos, Shekerdemian - PIs), which include the following multi-center studies:

Content
Pediatric Heart Network Clinical Research Studies

Title of Study

Principal Investigator(s)

ID Number

A Phase I Study of Dexmedetomidine Bolus and Infusion in Corrective Infant Cardiac Surgery: Safety and Pharmacokinetics

Dean Andropoulos

NA

Collaborative Learning Study of Perioperative Care of Infants with Congenital Heart Disease

Lara Shekerdemian

NA

Residual Lesion Score Study

Carlos Mery

NA

Pediatric Echocardiography Z-Score and ECG Study

Ricardo Pignatelli
Jeff Kim

NA

Real-Time Predictive Physiological Monitoring for Improving Patient Outcomes After Stage I Palliation

Craig Rusin

NA

Building an E-health Platform to Improve Adolescent Transition and Transfer of Care

Keila Lopez

NA

Fontan Growth Study

Tom Seery

NA

Off-Label Use of the Melody Valve

Athar Qureshi

NA

Content

A few of our non-PHN related research activities include the following:

Content
Non-Pediatric Heart Network Clinical Research Studies

Title of Study

Principal Investigator(s)

ID Number

A Biomarker to Predict Cardiovascular Events in Patients with Aortic Dilation

Shaine Morris

R21HL121630

Maternal Hyperoxygenation in Fetal Left Heart Hypoplasia

Judith Becker

NA

A Standardization of a Novel Method to Assess Fetal Cardiac Function: Myocardial Deformation

Shiraz Maskatia

NA

Postzygotic Cardiac Somatic Mutations and the Knudson Model - A Primary Role in the Etiology of Congenital Heart Disease

Wesley Vick

NA

Heading

Current Basic Research Projects

Content
Basic Research Studies

Title of Study

Principal Investigator(s)

ID Number

Phenotyping Embryonic Mammalian Heart Function Using OCT

Mary Dickinson

R01HL095586

Retinoid-Related Genes in Diaphragm and Cardiac Development

Daryl Scott

R01HD064667

Fabrication, Perfusion and Imaging of Pre-Vascularized Hydrogel Tissue Scaffolds

Mary Dickinson

R01HL097520

Consortium for Broad Based Disease Phenotyping of Knockout Mice

Art Beaudet
Corey Reynolds
Rich Paylor
Mary Dickinson

U54HG006348

Consortium for Broad Based Disease Phenotyping of Knockout Mice -- Embryonic Lethal Analysis Supplement

Art Beaudet
Mary Dickinson

U54HG006348-S1

Biomechanics of Early Mammalian Cardiogenesis

Irina Larina

R01HL120140

Neurovascular Regeneration

Mary Dickinson

BRPR01EB016629

A Nuclear Receptor COUP-TFII in Vascular Function: Angiogenesis and Tumorigenesis

Sophia Tsai

R01HL076448

Nuclear Orphan Receptor, COUP-TFII, in Energy Metabolism and Disease

Sophia Tsai

R01HL114539

Regulation of Hematopoietic Progenitors by de novo DNA Methylation

Peggy Goodell

R01DK092883

Human Embryonic Stem Cell Training and Culture Core

Peggy Goodell

P01GM081627

Mechanical Regulation of Vessel Remodeling and Angiogenesis

Mary Dickinson

NA

Hippo Signaling in Cardiac Regeneration

James Martin

NA

Genome-Wide Association Study for Hypoplastic Left Heart and Related Defects

John Belmont

R01HL090506

Molecular Pathogenesis of Myotonic Dystrophy

Thomas Cooper

R01AR045653

The Role of RERE in Congenital Cardiac Anomalies

Daryl Scott
George Taffet
Mark Entman
Mary Dickinson

NA

Functional Characterization of Nexilin Mutations Associated with Hypertrophic and Dilated Cardiomyopathy Using Knock-In Mouse Models

Yuxin Fan

NA

Heading

Research Faculty

Content

Carolyn Altman, M.D. - Pediatric echocardiography

Dean Andropoulos, M.D. - Brain protection for infant cardiac surgery

Ayse Akcan Arikan, M.D. - Pediatric critical care

Rahul Baijal, M.D. - Pediatric Anesthesiology

Manish Bansal, M.D. - Pediatric cardiology Judith Becker, M.D. fetal Left Heart Hypoplasia

John Belmont, M.D. - CV genetics, cardiovascular malformations and connective tissue disorders

Kenneth Brady, M.D. - Prevention of neurologic injury in children with CV disease

Thomas Cooper, M.D. - Alternative splicing in cardiac development and disease

William Dryer, M.D. - New heart failure therapies, management of HLA sensitized patients before/after transplant

Blaine Easley, M.D. - New methods for monitoring and management of children with heart disease

Yuxin Fan, M.D., Ph.D. - Diagnostic tests for acquired and genetic cardiac diseases, viral myocarditis

Peggy Goodell, M.D. - Hematopoietic stem cells, epigenetic modifications

Amir Jeewa, M.D. - Pediatric heart transplantation, cardiomyopathies, mechanical circulatory support

Leda Kloudas, Ph.D. - Pediatric congenital heart disease

William Kyle, M.D. - Outpatient cardiology

Scott LeMaire, M.D. - Basic and clinical research on aortic disease and aortic wall degeneration

George Mallory, M.D. - Pulmonary hypertension and lung transplantation

James Martin, M.D., Ph.D. - Hippo, Wnt, Bmp signaling in development, regeneration, heart disease

Christina Miyake, MS, M.D. - Inherited cardiac arrhythmia syndromes

Brady Moffett, Phar, M.D., MPH - Clinical pediatrics

Shaine Morris, M.D., MPH - Advanced imaging techniques for genetically-triggered aortopathies

Emad Mossad, M.D. - Neuromonitoring during repair of congenital heart disease

Dhaval Parekh, M.D. - Pediatric cardiology, pediatric/adult congenital heart disease

Ricardo Pignatelli, M.D. - Echocardiography, pediatric cardiomyopathy, ultrasound-targeted microbubbles, Duchenne muscular dystrophy

Fadel Ruiz, M.D. - Pediatric pulmonary hypertension, cystic fibrosis

Craig Rusin, Ph.D. - Physiological signal processing and algorithm development

Daryl Scott, M.D., Ph.D. - Genetics of congenital diaphragmatic hernia, esophageal atresia, cardiomyopathies

Lara Shekerdemian, M.D. - Cardiovascular physiology and mechanical cardiopulmonary support

Amy Sims, M.D. - Pediatric HIV cardiovascular complications

Jesus Vallejo, M.D. - TLR3/TLR4 in acute myocarditis, signal transduction pathways

Eric Williams, M.D. - Pediatric septic shock and stroke